CDC27在肿瘤中的研究进展
Research Progress of CDC27 in Tumor
DOI: 10.12677/ACM.2023.1361466, PDF,   
作者: 巴 胜:青海大学研究生院,青海 西宁;王丰梅*:青海大学附属医院病理科,青海 西宁
关键词: CDC27细胞周期预后标志物靶点CDC27 Cell Cycle Prognostic Flagbits The Target Spot
摘要: 细胞周期紊乱在肿瘤的发生发展中起重要作用,为实现对恶性肿瘤的早期诊断,改善患者临床症状,本文综述了CDC27在肿瘤发生发展中的作用以及在常见肿瘤中的表达及临床意义,关于CDC27在癌症发病机制中的作用及其临床重要性的研究相对较少,收集CDC27的最新研究成果,可以在常见肿瘤的早期诊断、疗效评估及预后判断方面提供新的方向。
Abstract: Cell cycle disorders play an important role in the occurrence and development of tumours. In order to achieve the early diagnosis of malignant tumours and improve the clinical symptoms of patients, this article summarizes the role of CDC27 in the development of tumours and its expression and clinical significance in common tumours. There are relatively few studies on the role of CDC27 in the pathogenesis of cancer and its clinical importance. Collecting the latest research results of CDC27 can provide a new direction in the early diagnosis, efficacy evaluation and prognosis judgment of common tumors.
文章引用:巴胜, 王丰梅. CDC27在肿瘤中的研究进展[J]. 临床医学进展, 2023, 13(6): 10476-10481. https://doi.org/10.12677/ACM.2023.1361466

参考文献

[1] Kazemi-Sefat, G.E., Keramatipour, M., Talebi, S., et al. (2021) The Importance of CDC27 in Cancer: Molecular Pathol-ogy and Clinical Aspects. Cancer Cell International, 21, Article No. 160. [Google Scholar] [CrossRef] [PubMed]
[2] Qiu, L., Zhou, R., Luo, Z., Wu, J. and Jiang, H. (2022) CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma. Frontiers in Oncology, 12, Article ID: 774458. [Google Scholar] [CrossRef] [PubMed]
[3] Chang, C.L., Huang, K.C., Chen, T.W., et al. (2022) Prognostic and Clinical Significance of Subcellular CDC27 for Patients with Rectal Adenocarcinoma Treated with Adjuvant Chemother-apy. Oncology Letters, 24, Article No. 238. [Google Scholar] [CrossRef] [PubMed]
[4] Song, Y., Song, W. and Li, Z.M. (2021) Corrigendum: CDC27 Pro-motes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma. Frontiers in Oncology, 10, Article ID: 583698. [Google Scholar] [CrossRef] [PubMed]
[5] Abbaspourkharyeki, M., Anvekar, N.J. and Ramachandra, N.B. (2020) The Possible Role of Point Mutations and Activation of the CDC27 Gene in Progression of Multiple Myeloma. Meta Gene, 26, Article ID: 100761. [Google Scholar] [CrossRef
[6] Qiu, L., Wu, J., Pan, C., et al. (2016) Downregulation of CDC27 Inhibits the Proliferation of Colorectal Cancer Cells via the Accumulation of p21Cip1/Waf1. Cell Death & Dis-ease, 7, e2074. [Google Scholar] [CrossRef] [PubMed]
[7] Zhao, C., Sun, J., Dang, Z., Su, Q. and Yang, J. (2022) Circ_0000775 Promotes the Migration, Invasion and EMT of Hepatic Carcinoma Cells by Recruiting IGF2BP2 to Stabi-lize CDC27. Pathology Research and Practice, 235, Article ID: 153908. [Google Scholar] [CrossRef] [PubMed]
[8] Xin, Y.F., Ning, S.L., Zhang, L. and Cui, M. (2018) CDC27 Facil-itates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition. Cellular Physiology and Biochemistry, 50, 501-511. [Google Scholar] [CrossRef] [PubMed]
[9] Wu, R.P., Li, Q.L., Wu, F. and Shi, C.M. (2020) Comprehensive Analysis of CDC27 Related to Peritoneal Metastasis by Whole Exome Sequencing in Gastric Cancer. OncoTargets and Therapy, 13, 3335-3346. [Google Scholar] [CrossRef
[10] Zhu, J.B., Liu, X.B., et al. (2022) Circular RNA circSLC8A1 Inhibits the Proliferation and Invasion of Glioma Cells through Targeting the miR-214-5p/CDC27 Axis. Metabolic Brain Disease, 37, 1015-1023. [Google Scholar] [CrossRef] [PubMed]
[11] 冯焯莹. Mir-218-2通过靶向抑制CDC27促进胶质细胞瘤的生长、转移和耐药研究[D]: [硕士学位论文]. 滨州: 滨州医学院, 2016.
[12] Talvinen, K., Karra, H., Pitkänen, R., et al. (2013) Low cdc27 and High Securin Expression Predict Short Survival for Breast Cancer Patients. APMIS, 121, 945-953. [Google Scholar] [CrossRef] [PubMed]
[13] 朱枫, 王辉, 彭蕾, 夏存燕, 邓旭, 笪文悦, 李青. 结直肠癌KRAS、NRAS、BRAF基因突变和MSI状态与其临床病理特征的关系[J]. 江苏医药, 2022, 48(6): 561-565.
[14] Qiu, L., Tan, X., Lin, J.X. and Liu, R.-Y. (2017) CDC27 Induces Metastasis and Invasion in Colorectal Cancer via the Promotion of Epithelial-to-Mesenchymal Transition. Journal of Cancer, 8, 2626-2635. [Google Scholar] [CrossRef] [PubMed]
[15] 高菲, 郭业兵, 王木森. 结直肠癌组织中错配修复蛋白基因表达与临床病理及KRAS BRAF基因突变的相关性分析[J]. 实用医技杂志, 2022, 29(5): 475-479.
[16] 罗喜顺, 王海鹏, 朱袭嘉, 李盛国, 蒋世宇, 张琪琦. 结直肠癌患者Kras基因突变与分化程度及组织类型的相关性研究[J]. 华夏医学, 2022, 35(1): 22-26.
[17] 吴凡. 全外显子组测序筛选胃癌腹膜转移相关基因CDC27 [D]: [博士学位论文]. 福州: 福建医科大学, 2019.
[18] Feng, Z.Y., Zhang, L.P. and Zhou, J.C. (2017) Mir-218-2 Promotes Glioblastomas Growth, Invasion and Drug Resistance by Targeting CDC27. Oncotarget, 8, 6304-6318. [Google Scholar] [CrossRef] [PubMed]
[19] Kornepati, A., et al. (2022) Programmed Death Ligand 1 Signals in Cancer Cells. Nature Reviews Cancer, 22, 174-189. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, Y.X., Huang, C.Y., Chiu, H.J., et al. (2023) Nucle-ar-Localized CTEN Is a Novel Transcriptional Regulator and Promotes Cancer Cell Migration through Its Downstream Target CDC27. Journal of Physiology and Biochemistry, 79, 163-174. [Google Scholar] [CrossRef] [PubMed]
[21] Lee, S.J. and Langhans, S.A. (2012) Anaphase-Promoting Com-plex/Cyclosome Protein CDC27 Is a Target for Curcumin-Induced Cell Cycle Arrest and Apoptosis. BMC Cancer, 12, Article No. 44. [Google Scholar] [CrossRef] [PubMed]
[22] Link, L.A., Howley, B.V., Hussey, G.S. and Howe, P.H. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Molecular Cancer Re-search: MCR, 14, 634-646. [Google Scholar] [CrossRef
[23] Melloy, P.G. (2020) The Anaphase-Promoting Complex: A Key Mitotic Regulator Associated with Somatic Mutations Occurring in Cancer. Genes Chromosomes Cancer, 59, 189-202. [Google Scholar] [CrossRef] [PubMed]