系统性红斑狼疮伴动脉粥样硬化危险因素研究进展

Advances in the Study of Risk Factors for Systemic Lupus Erythematosus with Atherosclerosis

摘要: 系统性红斑狼疮(Systemic Lupus Erythematosus, SLE)好发于育龄女性，是以自身免疫抗体和免疫复合物为媒介，慢性炎症性组织损伤为主要表现的一种自身免疫性疾病。它的炎症损伤可涉及到全身各个脏器，其中以累及心血管系统所引起的不良影响是最严重的。大量的研究资料显示SLE患者的前期死亡原因主要是疾病活动，后期则往往发展成动脉粥样硬化(Atherosclerosis, AS)，从而使死亡率升高。经典的危险因素如肥胖、吸烟等可以加速AS进展，但对非传统危险因素控制并采取全面干预措施亦能改善SLE病人的预后，降低死亡率。因此SLE治疗中必须重视血管病变的防治。本文将重点讨论近期系统性红斑狼疮伴动脉粥样硬化(SLE-AS)危险因素的研究进展。

Abstract: Systemic Lupus Erythematosus (SLE) occurs in women of childbearing age and is an autoimmune disease with chronic inflammatory tissue damage mediated by autoimmune antibodies and im-mune complexes. Its inflammatory damage can involve all organs of the body, with the most serious adverse effects caused by the involvement of the cardiovascular system. A large number of studies have shown that the main cause of death in SLE patients is disease activity in the early stages, while the later stages tend to develop atherosclerosis (AS), which increases mortality. While classical risk factors such as obesity and smoking can accelerate the progression of AS, control of non-traditional risk factors and comprehensive interventions can also improve the prognosis of SLE patients and reduce mortality. Therefore, the prevention and treatment of vascular lesions must be emphasized in the management of SLE. In this article, we will focus on recent advances in the study of risk fac-tors for SLE with atherosclerosis (SLE-AS).