雷公藤红素改善自身免疫性疾病的研究进展
Research Progress on Improving Autoimmune Diseases with Celastrol
摘要: 雷公藤是卫矛科雷公藤属木质藤本植物,其根部可入药,用于治疗风湿免疫性疾病,具有悠久的使用历史。雷公藤红素为雷公藤的主要活性成分之一,经由多靶点、多信号通路发挥免疫抑制效应,对自身免疫性疾病具有良好的改善作用。近年来,雷公藤红素因其潜在的药用价值引起广泛关注。本文总结雷公藤红素改善自身免疫性疾病的药理活性和机制,为其进一步研究开发提供参考。
Abstract: Celastrol is a woody vine of the family Celastraceae, belonging to the genus Tripterygium. Its roots can be used as medicine to treat rheumatic and immune diseases, and it has a long history of use. Celastrol is one of the main active components of Tripterygium wilfordii, which exerts immunosup-pressive effects through multiple targets and signaling pathways, and has a good improvement effect on autoimmune diseases. In recent years, celastrol has attracted widespread attention due to its potential medicinal value. This article summarizes the pharmacological activity and mechanism of celastrol in improving autoimmune diseases, providing reference for its further research and development.
文章引用:刘琰, 戴岳. 雷公藤红素改善自身免疫性疾病的研究进展[J]. 药物资讯, 2023, 12(4): 269-275. https://doi.org/10.12677/PI.2023.124034

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