纳米金声动力损伤蛋白质的活性研究
Study on Sonodynamic Damage Proteins of Gold Nanoparticles
DOI: 10.12677/OJNS.2023.114068, PDF,    科研立项经费支持
作者: 李京壑, 宁 秀*, 王孟圆*, 刘 锵, 金 波, 刘 彬：辽宁大学药学院，辽宁 沈阳；王冬晶：北京利龄恒泰药业有限公司，北京
关键词: 超声；金纳米颗粒；人血清白蛋白；损伤；Ultrasound； Gold Nanoparticles； Human Serum Albumin； Damage
摘要: 本研究采用荧光光谱和紫外–可见光谱的方法，考察了超声照射下球形纳米金(Gold Nanospheres, GNSs)对人血清白蛋白(Human Serum Albumin, HSA)的损伤，并探究了GNSs浓度和超声功率对HSA分子损伤的影响。研究结果显示，在一定条件下，HSA的损伤随着GNSs浓度的增加和超声功率的增大而加剧。进一步研究发现，超声可激活GNSs产生活性氧物质，且活性氧的含量随着GNSs浓度和超声功率的增大而增加，这一研究对分子水平上深入研究GNSs合理应用具有重要意义。
Abstract: This paper investigated the activity of Gold Nanospheres (GNSs) damaging Human Serum Albumin (HSA) under ultrasonic irradiation using fluorescence spectroscopy and UV-visible spectroscopy. The influence of GNSs concentration and ultrasonic power on the destruction of HSA molecular was further explored. The research results revealed that, under certain conditions, the activity of HSA decreased with increasing GNSs concentration and ultrasonic power. Additionally, the study also revealed that GNSs could be activated to produce reactive oxygen species after ultrasonic irra-diation, and its yield was positively correlated with GNSs concentration and ultrasonic power. This study holds significant importance in providing insights into the rational application of GNSs at the molecular level.
文章引用：李京壑, 宁秀, 王孟圆, 刘锵, 金波, 王冬晶, 刘彬. 纳米金声动力损伤蛋白质的活性研究[J]. 自然科学, 2023, 11(4): 570-577. https://doi.org/10.12677/OJNS.2023.114068

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