儿童IgA血管炎伴肾炎早期肾损伤标记物
Early Renal Injury Markers in Children with IgA Vasculitis and Nephritis
DOI: 10.12677/ACM.2023.1371526, PDF,   
作者: 徐一鸣：青海大学研究生院，青海 西宁；吴秀萍*：青海大学附属医院，青海 西宁
关键词: 儿童；IgA血管炎伴肾炎；标记物；Children； IgA Vasculitis with Nephritis； Markers
摘要: IgA血管炎(IgAV)又称过敏性紫癜(HSP)是儿童最常见的系统性血管炎，大部分预后较好，部分患儿可累及肾脏，称为IgA血管炎伴肾炎(IgAVN)，肾脏受累是远期预后的主要决定因素，少数IgAVN可能发展为肾衰竭或终末期肾病，早期识别并治疗对患儿预后及生存质量有较大提升。目前评估肾脏病理变化的“金标准”是肾穿刺活检，但因其为有创性检查，临床上适用度较为局限。因此寻找可靠的生物学标记物指标用于判断IgAVN早期肾损伤尤为重要。
Abstract: IgA vasculitis (IgAV), also known as allergic purpura (HSP), is the most common systemic vasculitis in children. Most patients have a good prognosis, and some may involve the kidneys, known as IgA vasculitis with nephritis (IgAVN). Renal volvement is the main determinant of long-term prognosis, and a few IgAVN can develop into renal failure or end-stage kidney disease. Early identification and treatment can greatly improve the prognosis and quality of life of children. At present, the “gold standard” for evaluating renal pathological changes is renal biopsy, but its clinical applicability is limited due to its invasive nature. Therefore, it is particularly important to find reliable biomarker indicators for detecting early renal injury in IgAVN.
文章引用：徐一鸣, 吴秀萍. 儿童IgA血管炎伴肾炎早期肾损伤标记物[J]. 临床医学进展, 2023, 13(7): 10931-10935. https://doi.org/10.12677/ACM.2023.1371526

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