艾滋病患者代谢综合征流行情况
Prevalence of Metabolic Syndrome in AIDS Patients
摘要: 接受抗逆转录病毒治疗的艾滋病患者代谢综合征患病率明显偏高,受到传统危险因素和HIV相关因素影响,且影响艾滋病患者的长期生存质量。研究从接受抗逆转录病毒治疗艾滋病患者的肥胖、高血糖、高血脂及高血压方面进行综述。总结发现,艾滋病患者代谢综合征患病率明显偏高受到多方面因素影响,且值得临床重视;文章将为艾滋病患者的代谢管理提供一定借鉴及参考。
Abstract: The prevalence of metabolic syndrome in AIDS patients receiving antiretroviral therapy is signifi-cantly high, which is affected by traditional risk factors and HIV-related factors and affects the long-term quality of life of AIDS patients. Studies on obesity, hyperglycemia, hyperlipidemia, and hypertension in AIDS patients receiving antiretroviral therapy were reviewed. It was found that the prevalence of metabolic syndrome in AIDS patients was significantly high, which was affected by many factors and worthy of clinical attention. This article will provide some reference for metabolic management of AIDS patients.
文章引用:罗剑明, 张景慧. 艾滋病患者代谢综合征流行情况[J]. 临床医学进展, 2023, 13(7): 10989-10995. https://doi.org/10.12677/ACM.2023.1371534

参考文献

[1] 中华医学会感染病学分会艾滋病丙肝学组, 中国疾病预防与控制中心. 中国艾滋病诊疗指南(2021年版) [J]. 中华临床感染病杂志, 2021, 14(5): 321-343.
[2] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版) [J]. 中华糖尿病杂志, 2021(4): 315-409.
[3] Ortíz, D.W., Marroquin, H.E., Larson, L., et al. (2022) Metabolic Syn-drome in People with HIV from Guatemala: Analysis of Components and Risk Factors. International Journal of STD & AIDS, 33, 987-994. [Google Scholar] [CrossRef] [PubMed]
[4] Savinelli, S., Wrigley, K.N., Feeney, E.R., et al. (2022) Obesity in HIV Infection: Host-Pathogen Interaction. AIDS, 36, 1477-1491. [Google Scholar] [CrossRef
[5] Pantazis, N., Papastamopoulos, V., Antoniadou, A., et al. (2022) Changes in Body Mass Index after Initiation of Antiretroviral Treatment: Differences by Class of Core Drug. Vi-ruses, 14, Article No. 1677. [Google Scholar] [CrossRef] [PubMed]
[6] Han, W.M., Law, M.G., Choi, J.Y., et al. (2022) Weight Changes, Meta-bolic Syndrome and All-Cause Mortality among Asian Adults Living with HIV. HIV Medicine, 23, 274-286. [Google Scholar] [CrossRef] [PubMed]
[7] Khuon, D., Rupasinghe, D., Saphonn, V., et al. (2023) BMI as a Predictor of High Fasting Blood Glucose among People Living with HIV in the Asia-Pacific Region. HIV Medicine, 24, 139-152. [Google Scholar] [CrossRef] [PubMed]
[8] Gómez-Ayerbe, C., Palacios, R., Mayorga, M., et al. (2022) Weight Changes after First-Line Antiretroviral Initiation in a Cohort of HIV-Positive Patients in Southern Spain (CAPOTA Study). International Journal of STD & AIDS, 33, 1119-1123. [Google Scholar] [CrossRef] [PubMed]
[9] Castro, A.C., Silveira, E.A., Falco, M.O., et al. (2016) Over-weight and Abdominal Obesity in Adults Living with HIV/AIDS. Revista da Associação Médica Brasileira (1992), 62, 353-360. [Google Scholar] [CrossRef] [PubMed]
[10] Sax, P.E., Erlandson, K.M., Lake, J.E., et al. (2020) Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials. Clinical Infectious Diseases, 71, 1379-1389. [Google Scholar] [CrossRef] [PubMed]
[11] Chihota, B.V., Mandiriri, A., Shamu, T., et al. (2022) Metabolic Syndrome among Treatment-Naïve People Living with and without HIV in Zambia and Zimbabwe: A Cross-Sectional Analysis. Journal of the International AIDS Society, 25, e26047. [Google Scholar] [CrossRef] [PubMed]
[12] Bailin, S.S. and Koethe, J.R. (2023) Diabetes in HIV: The Link to Weight Gain. Current HIV/AIDS Reports, 20, 9-18. [Google Scholar] [CrossRef] [PubMed]
[13] Borkowska, T., Chkhartishvili, N., Karkashadze, E., et al. (2022) The Prevalence of Hyperglycemia and Its Impact on Mortality among People Living with HIV in Georgia. PLOS ONE, 17, e276749. [Google Scholar] [CrossRef] [PubMed]
[14] Slama, L., Barrett, B.W., Abraham, A.G., et al. (2021) Risk for Incident Diabetes Is Greater in Prediabetic Men with HIV than without HIV. AIDS, 35, 1605-1614. [Google Scholar] [CrossRef
[15] Isa, S.E., Oche, A.O., Kang’Ombe, A.R., et al. (2016) Human Immunodeficiency Virus and Risk of Type 2 Diabetes in a Large Adult Cohort in Jos, Nigeria. Clinical Infectious Diseases, 63, 830-835. [Google Scholar] [CrossRef] [PubMed]
[16] Buendia, J.R., Sears, S., Griffin, E., et al. (2022) Prevalence and Risk Factors of Type II Diabetes Mellitus among People Living with HIV in Texas. AIDS Care, 34, 900-907. [Google Scholar] [CrossRef] [PubMed]
[17] Shen, Y., Wang, Z., Liu, L., et al. (2013) Preva-lence of Hyperglycemia among Adults with Newly Diagnosed HIV/AIDS in China. BMC Infectious Diseases, 13, Arti-cle No. 79. [Google Scholar] [CrossRef] [PubMed]
[18] Xu, Y., Chen, X. and Wang, K. (2017) Global Preva-lence of Hypertension among People Living with HIV: A Systematic Review and Meta-Analysis. Journal of the Ameri-can Society of Hypertension, 11, 530-540. [Google Scholar] [CrossRef] [PubMed]
[19] Mills, K.T., Bundy, J.D., Kelly, T.N., et al. (2016) Global Dispari-ties of Hypertension Prevalence and Control: A Systematic Analysis of Population-Based Studies from 90 Countries. Circulation, 134, 441-450. [Google Scholar] [CrossRef
[20] Davis, K., Moorhouse, L., Maswera, R., et al. (2023) Associations between HIV Status and Self-Reported Hypertension in a High HIV Prevalence Sub-Saharan Afri-can Population: A Cross-Sectional Study. BMJ Open, 13, e67327. [Google Scholar] [CrossRef] [PubMed]
[21] Isa, S.E., Kang’Ombe, A.R., Simji, G.S., et al. (2017) Hyper-tension in Treated and Untreated Patients with HIV: A Study from 2011 to 2013 at the Jos University Teaching Hospital, Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 111, 172-177. [Google Scholar] [CrossRef] [PubMed]
[22] Chang, D., Esber, A., Dear, N., et al. (2022) Non-Communicable Dis-eases in Older People Living with HIV in Four African Countries: A Cohort Study. The Lancet HIV, 9, S5. [Google Scholar] [CrossRef
[23] Sadinski, L.M., Westreich, D., Edmonds, A., et al. (2023) Hypertension and One-Year Risk of All-Cause Mortality among Women with Treated HIV in the United States. AIDS, 37, 679-688. [Google Scholar] [CrossRef
[24] Xu, X., Chen, X., Lin, H., et al. (2021) General and Ab-dominal Obesity and Incident Hypertension among People Living with HIV on Antiretroviral Therapy. AIDS Care, 33, 1616-1620. [Google Scholar] [CrossRef] [PubMed]
[25] Remch, M., Franceschini, N., Davy-Mendez, T., et al. (2022) Hypertension Burden, Treatment, and Control among People with HIV at a Clinical Care Center in the Southeastern US, 2014-2019. AIDS Care, 1-10. [Google Scholar] [CrossRef] [PubMed]
[26] Duan, Y., Zhao, H., Tang, W., et al. (2022) Longitudinal Analysis of New-Onset Non-AIDS-Defining Diseases among People Living with HIV: A Real-World Observational Study. HIV Medicine, 23, 32-41. [Google Scholar] [CrossRef] [PubMed]
[27] Yang, C., Wang, D., Ma, Y., et al. (2022) Effectors of Hyperlipidemia among HIV/AIDS Patients with Second-Line Antiretroviral Therapy Based on Register Data. Current HIV Research, 20, 373-379. [Google Scholar] [CrossRef
[28] Buendia, J., Sears, S. and Mgbere, O. (2022) Preva-lence and Risk Factors of High Cholesterol and Triglycerides among People with HIV in Texas. AIDS Research and Therapy, 19, Article No. 43. [Google Scholar] [CrossRef] [PubMed]
[29] Ojong, E., Iya, B., Djeufouata, J., et al. (2022) Metabolic Syn-drome and Its Components among HIV/AIDS Patients on Antiretroviral Therapy and ART-Naïve Patients at the Univer-sity of Calabar Teaching Hospital, Calabar, Nigeria. African Health Sciences, 22, 410-417. [Google Scholar] [CrossRef] [PubMed]
[30] Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285, 2486-2497. [Google Scholar] [CrossRef] [PubMed]
[31] Alberti, K.G., Zimmet, P. and Shaw, J. (2005) The Metabolic Syn-drome—A New Worldwide Definition. The Lancet, 366, 1059-1062. [Google Scholar] [CrossRef
[32] Møller, S.P., Amare, H., Christensen, D.L., et al. (2020) HIV and Metabolic Syndrome in an Ethiopian Population. Annals of Human Biology, 47, 457-464. [Google Scholar] [CrossRef] [PubMed]
[33] Aurpibul, L., Namwongprom, S., Sudjaritruk, T., et al. (2020) Metabolic Syndrome, Biochemical Markers, and Body Composition in Youth Living with Perinatal HIV Infection on Antiretroviral Treatment. PLOS ONE, 15, e230707. [Google Scholar] [CrossRef] [PubMed]