肠道菌群与自身免疫性甲状腺疾病相关性的研究进展
Research Progress on the Relationship between Gut Microbiota and Autoimmune Thyroid Disease
DOI: 10.12677/ACM.2023.1371559, PDF,   
作者: 邢粉霞：青海大学研究生学院，青海 西宁；江 彤*：青海大学附属医院内分泌科，青海 西宁
关键词: 自身免疫性甲状腺疾病；肠道菌群；Graves病；桥本甲状腺炎；粪菌移植；Autoimmune Thyroid Disease； Gut Microbiota； Graves Disease； Hashimoto Thyroiditis； Fecal Bacteria Transplantation
摘要: 肠道菌群是人体共生的重要组成部分，对宿主的营养、代谢、屏障、免疫至关重要，菌群稳态受损会引起胃肠道及全身疾病。自身免疫性甲状腺疾病(AITD)是一种器官特异性自身免疫性疾病，其发病机制尚不明确，目前认为与遗传易感性、环境因素、免疫失衡有关，其中免疫失衡是核心因素。近年研究表明，和健康人群相比，AITD患者的肠道菌群存在明显差异。本文通过探讨肠道菌群参与AITD发生发展的可能机制以及AITD患者肠道菌群的特征变化，以期为AITD的诊断及治疗提供新视角。
Abstract: The gut microbiota is an important component of human symbiosis, which is crucial for the host’s nutrition, metabolism, barrier, and immunity. Impaired microbiota homeostasis can cause gas-trointestinal and systemic diseases. Autoimmune Thyroid disease (AITD) is an organ specific au-toimmune disease, and its pathogenesis is still unclear. At present, it is believed that it is related to genetic susceptibility, environmental factors, and immune imbalance, of which immune imbalance is the core factor. Recent studies have shown that the gut microbiota of AITD patients is significantly different from that of healthy people. This article discusses the possible mechanism of gut microbiota participating in the occurrence and development of AITD and the characteristic changes of gut microbiota in AITD patients, in order to provide a new perspective for the diagnosis and treatment of AITD.
文章引用：邢粉霞, 江彤. 肠道菌群与自身免疫性甲状腺疾病相关性的研究进展[J]. 临床医学进展, 2023, 13(7): 11166-11171. https://doi.org/10.12677/ACM.2023.1371559

参考文献

[1] Docimo, G., Cangiano, A., Romano, R.M., et al. (2020) The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases. Frontiers in Endocrinology, 11, Article 586529. [Google Scholar] [CrossRef] [PubMed]
[2] Sun, Y., Chen, Q., Lin, P., et al. (2019) Characteristics of Gut Microbiota in Patients with Rheumatoid Arthritis in Shanghai, China. Frontiers in Cellular and Infection Microbiology, 9, Article 369. [Google Scholar] [CrossRef] [PubMed]
[3] Luo, X.M., Edwards, M.R., Mu, Q., et al. (2018) Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus. Applied & Environmental Microbiology, 84, e02288-17. [Google Scholar] [CrossRef] 
[4] Cardoneanu, A., Cozma, S., Rezus, C., et al. (2021) Characteristics of the Intestinal Microbiome in Ankylosing Spondylitis. Experimental and Therapeutic Medicine, 22, Article No. 676. [Google Scholar] [CrossRef] [PubMed]
[5] Qin, J., Li, R., Raes, J., et al. (2010) A Human Gut Microbial Gene Catalogue Established by Metagenomic Sequencing. Nature, 464, 59-65. [Google Scholar] [CrossRef] [PubMed]
[6] Fang, H., Kang, J. and Zhang, D. (2017) Microbial Production of Vitamin B 12: A Review and Future Perspectives. Microbial Cell Factories, 16, Article No. 15. [Google Scholar] [CrossRef] [PubMed]
[7] Virili, C., Fallahi, P., Antonelli, A., Benvenga, S. and Centanni, M. (2018) Gut Microbiota and Hashimoto’s Thyroiditis. Reviews in Endocrine and Metabolic Disorders, 19, 293-300. [Google Scholar] [CrossRef] [PubMed]
[8] Catanzaro, R., Anzalone, M., Calabrese, F., et al. (2014) The Gut Microbiota and Its Correlations with the Central Nervous System Disorders. Panminerva Medica, 57, 127-143.
[9] Gensollen, T., Iyer, S.S., Kasper, D.L. and Blumberg, R.S. (2016) How Colonization by Microbiota in Early Life Shapes the Immune System. Science, 352, 539-544. [Google Scholar] [CrossRef] [PubMed]
[10] Bruno, R., Giannasio, P., Ronga, G., et al. (2004) Sodium Iodide Symporter Expression and Radioiodine Distribution in Extrathyroidal Tissues. Journal of Endocrinological Investigation, 27, 1010-1014. [Google Scholar] [CrossRef] 
[11] De la Vieja, A. and Santisteban, P. (2018) Role of Iodide Metabolism in Physiology and Cancer. Endocrine-Related Cancer, 25, R225-R245. [Google Scholar] [CrossRef] 
[12] Vought, R.L., Brown, F.A., Sibinovic, K.H. and Mc Daniel, E.G. (1972) Effect of Changing Intestinal Bacterial Flora on Thyroid Function in the Rat. Hormone and Metabolic Research, 4, 43-47. [Google Scholar] [CrossRef] [PubMed]
[13] Navarro, A.M., Suen, V.M.M., Souza, I.M., De Oliveira, J.E.D. and Marchini, J.S. (2005) Patients with Severe Bowel Malabsorption Do Not Have Changes in Iodine Status. Nutrition, 21, 895-900. [Google Scholar] [CrossRef] [PubMed]
[14] Michalaki, M., Volonakis, S., Mamali, I., et al. (2014) Dietary Io-dine Absorption Is Not Influenced by Malabsorptive Bariatric Surgery. Obesity Surgery, 24, 1921-1925. [Google Scholar] [CrossRef] [PubMed]
[15] Wichman, J., Winther, K.H., Bonnema, S.J. and Hegedüs, L. (2016) Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Au-toimmune Thyroiditis: A Systematic Review and Meta-Analysis. Thyroid, 26, 1681-1692. [Google Scholar] [CrossRef] [PubMed]
[16] Hrdina, J., Banning, A., Kipp, A., et al. (2009) The Gastrointestinal Microbiota Affects the Selenium Status and Selenoprotein Expression in Mice. The Journal of Nutritional Biochemistry, 20, 638-648. [Google Scholar] [CrossRef] [PubMed]
[17] Lavu, R.V.S., Van De Wiele, T., Pratti, V.L., Tack, F. and Laing, G.U. (2016) Selenium Bioaccessibility in Stomach, Small Intestine and Colon: Comparison between Pure Se Compounds, Se-Enriched Food Crops and Food Supplements. Food Chemistry, 197, 382-387. [Google Scholar] [CrossRef] [PubMed]
[18] Sabatino, L., Iervasi, G., Ferrazzi, P., Francesconi, D. and Chopra, I.J. (2000) A Study of Iodothyronine 5’-Monodeiodinase Activities in Normal and Pathological Tissues in Man and Their Comparison with Activities in Rat Tissues. Life Sciences, 68, 191-202. [Google Scholar] [CrossRef] 
[19] Fekete, C., Gereben, B., Doleschall, M., et al. (2004) Lip-opolysaccharide Induces Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus: Implications for the Nonthyroidal Illness Syndrome. Endocrinology, 145, 1649-1655. [Google Scholar] [CrossRef] [PubMed]
[20] Hazenberg, M.P., De Herder, W.W. and Visser, T.J. (1988) Hydrolysis of Iodothyronine Conjugates by Intestinal Bacteria. FEMS Microbiology Reviews, 4, 9-16.
[21] Roche, J. and Michel, R. (1960) On the Peripheral Metabolism of Thyroid Hormones. Annals of the New York Academy of Sciences, 86, 454-468. [Google Scholar] [CrossRef] [PubMed]
[22] DiStefano 3rd, J.J., de Luze, A. and Nguyen, T.T. (1993) Binding and Degradation of 3,5,3’-Triiodothyronine and Thyroxine by Rat Intestinal Bacteria. American Journal of Physiology-Endocrinology and Metabolism, 264, E966-E972. [Google Scholar] [CrossRef] 
[23] Hedblom, G.A., Reiland, H.A., Sylte, M.J., Johnson, T.J. and Baumler, D.J. (2018) Segmented Filamentous Bacteria—Metabolism Meets Immunity. Frontiers in Microbiology, 9, Article 1991. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, H., Liu, H., Liu, C., et al. (2022) Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease. Frontiers in Molecular Biosciences, 9, Article 841223. [Google Scholar] [CrossRef] [PubMed]
[25] Su, X., Yin, X., Liu, Y., et al. (2020) Gut Dysbiosis Contributes to the Imbalance of Treg and Th17 Cells in Graves’ Disease Patients by Propionic Acid. The Journal of Clinical Endo-crinology & Metabolism, 105, 3526-3547. [Google Scholar] [CrossRef] [PubMed]
[26] Masetti, G. and Ludgate, M. (2020) Microbiome and Graves’ Orbitopathy. European Thyroid Journal, 9, 78-86. [Google Scholar] [CrossRef] [PubMed]
[27] Kiseleva, E., Mikhailopulo, K., Sviridov, O., et al. (2011) The Role of Components of Bifidobacterium and Lactobacillus in Pathogenesis and Serologic Diagnosis of Autoimmune Thyroid Diseases. Beneficial Microbes, 2, 139-154. [Google Scholar] [CrossRef] 
[28] Benvenga, S. and Guarneri, F. (2016) Molecular Mimicry and Auto-immune Thyroid Disease. Reviews in Endocrine and Metabolic Disorders, 17, 485-498. [Google Scholar] [CrossRef] [PubMed]
[29] Chang, S.-C., Lin, S.-F., Chen, S.-T., et al. (2021) Alterations of Gut Microbiota in Patients with Graves’ Disease. Frontiers in Cellular and Infection Microbiology, 11, Article 663131. [Google Scholar] [CrossRef] [PubMed]
[30] Cornejo-Pareja, I., Ruiz-Limón, P., Gómez-Pérez, A.M., et al. (2020) Differential Microbial Pattern Description in Subjects with Autoimmune-Based Thyroid Diseases: A Pilot Study. Journal of Personalized Medicine, 10, Article No. 192. [Google Scholar] [CrossRef] [PubMed]
[31] Li, J., Sung, C.Y.J., Lee, N., et al. (2016) Probiotics Modulated Gut Microbiota Suppresses Hepatocellular Carcinoma Growth in Mice. Proceedings of the National Academy of Sciences of the United States of America, 113, E1306-E1315. [Google Scholar] [CrossRef] [PubMed]
[32] Yan, H.-X., An, W.-C., Chen, F., et al. (2020) Intestinal Microbiota Changes in Graves’ Disease: A Prospective Clinical Study. Bioscience Reports, 40, Article ID: BSR20191242. [Google Scholar] [CrossRef] 
[33] Jiang, W., Yu, X., Kosik, R.O., et al. (2021) Gut Microbiota May Play a Significant Role in the Pathogenesis of Graves’ Disease. Thyroid, 31, 810-820. [Google Scholar] [CrossRef] [PubMed]
[34] de Freitas Cayres, L.C., de Salis, L.V.V., Rodrigues, G.S.P., et al. (2021) Detection of Alterations in the Gut Microbiota and Intestinal Permeability in Patients with Hashimoto Thyroiditis. Frontiers in Immunology, 12, Article 579140. [Google Scholar] [CrossRef] [PubMed]
[35] Zhao, F., Feng, J., Li, J., et al. (2018) Alterations of the Gut Microbiota in Hashimoto’s Thyroiditis Patients. Thyroid, 28, 175-186. [Google Scholar] [CrossRef] [PubMed]
[36] Liu, S., An, Y., Cao, B., et al. (2020) The Composition of Gut Microbiota in Patients Bearing Hashimoto’s Thyroiditis with Euthyroidism and Hypothyroidism. International Journal of Endocrinology, 2020, Article ID: 5036959. [Google Scholar] [CrossRef] [PubMed]

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