儿童食物蛋白诱导性小肠结肠炎综合征诊疗研究进展

Research Progress on the Diagnosis and Treatment of Food Protein-Induced Enterocolitis Syndrome in Children

摘要: 食物蛋白诱导的小肠结肠炎综合征(Food protein-induced enterocolitis syndrome, FPIES)是一种并不罕见的非IgE介导的食物过敏反应，常在婴儿期发病，急性起病多见，但病理生理尚不完全清楚，而临床表现缺乏特异性。目前诊断主要依赖于病史、典型的临床表现以及回避可疑致敏食物后症状缓解，必要时需进行口服食物激发试验确诊。基于症状的严重程度的FPIES管理主要包括回避致敏食物及对症支持治疗，预后良好。回顾总结儿童FPIES的流行病学、临床表型、发病机制、疾病诊疗的最新进展，全面认识并掌握其临床特点，对儿童FPIES尤其是新生儿FPIES早期诊治、合理实施营养方案有积极意义。

Abstract: Food protein-induced enterocolitis syndrome (FPIES) is a not rare non-IgE mediated food allergic reaction, usually in infancy; acute onset is more common, but the pathophysiology is still not com-pletely clear. The clinical manifestations lack specificity. Diagnosis currently depends on history, typical clinical manifestations, and relief of symptoms after avoidance of suspected allergenic foods, and confirmation is made by oral food challenge if necessary. Management of FPIES based on symptom severity mainly includes avoidance of suspect allergenic foods and symptomatic supportive treatment. The prognosis is good. To review and summarize the latest progress in the epidemiology, clinical phenotype, pathogenesis, disease diagnosis, and treatment of FPIES in chil-dren, and to fully understand and grasp its clinical characteristics is of positive significance for early diagnosis and treatment and rational implementation of nutrition programs of FPIES in children, especially of FPIES in neonates.