慢性阻塞性肺疾病急性加重期患者的血清指标与肺功能的关系
Relationship between Serum Indexes and Lung Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
DOI: 10.12677/ACM.2023.1371565, PDF,   
作者: 寨宗然*:延安大学医学院,陕西 延安;张彩莲:延安大学附属医院呼吸与危重症医学科,陕西 延安
关键词: 慢性阻塞性肺疾病血清指标肺功能Chronic Obstructive Pulmonary Disease (COPD) Serum Index Pulmonary Function
摘要: 慢性阻塞性肺疾病是以持续气流受限为特征的慢性炎症疾病。其病死率及死亡率较高,对经济发展及公共卫生都造成了很大的压力。肺功能检查是诊断慢性阻塞性肺疾病的重要工具,本文就炎症细胞、细胞因子、血清淀粉样蛋白(SAA)、降钙素原、超敏C反应蛋白及一些炎症比值指标在COPD中的作用及其分别与肺功能的关系做简要综述。帮助危重症患者不能配合完成肺功能检查及其他不抗拒原因造成肺功能低质量结果提供一定的证据支持。
Abstract: Chronic obstructive pulmonary disease is a chronic inflammatory disease characterized by contin-uous airflow limitation. Its mortality rate is high, which has caused great pressure on economic de-velopment and public health. Pulmonary function examination is an important tool to diagnose chronic obstructive pulmonary disease. This article briefly reviews the roles of inflammatory cells, cytokines, serum amyloid, procalcitonin, high-sensitivity C-reactive protein and some inflammatory ratio indicators in COPD and their relationships with pulmonary function. To help critically ill pa-tients fail to cooperate with the completion of lung function examination and provide some evidence support for the low quality results of lung function caused by other irresistible reasons.
文章引用:寨宗然, 张彩莲. 慢性阻塞性肺疾病急性加重期患者的血清指标与肺功能的关系[J]. 临床医学进展, 2023, 13(7): 11209-11214. https://doi.org/10.12677/ACM.2023.1371565

参考文献

[1] Adeloye, D., Chua, S., Lee, C., et al. (2015) Global and Regional Estimates of COPD Prevalence: Systematic Review and Meta-Analysis. Journal of Global Health, 5, Article ID: 020415-15. [Google Scholar] [CrossRef] [PubMed]
[2] Rabe, K.F. and Watz, H. (2017) Chronic Obstructive Pulmonary Dis-ease. The Lancet, 389, 1931-1940. [Google Scholar] [CrossRef
[3] Soriano, J.B., Kendrick, P.J., Paulson, K.R., et al. (2020) Prevalence and Attributable Health Burden of Chronic Respiratory Diseases, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Respiratory Medicine, 8, 585-596. [Google Scholar] [CrossRef
[4] 冯国平. 加味川芎平喘合剂对稳定期慢性阻塞性肺疾病合并肺动脉高压患者血清爱帕琳肽和缺氧诱导因子-1α的影响[J]. 中医临床研究, 2020, 12(25): 59-61.
[5] 巫建康, 陈燕. 慢性阻塞性肺疾病的新定义及临床诊疗建议——基于2022年《柳叶刀》文件解读[J]. 中国全科医学, 2022, 26(2): 127-133.
[6] Silverman, E.K. (2020) Genetics of COPD. Annual Review of Physiology, 82, 413-431. [Google Scholar] [CrossRef] [PubMed]
[7] Lin, T., Chen, W., Ding, Z., et al. (2019) Correla-tions between Serum Amyloid A, C-Reactive Protein and Clinical Indices of Patients with Acutely Exacerbated Chronic Obstructive Pulmonary Disease. Journal of Clinical Laboratory Analysis, 33, e22831. [Google Scholar] [CrossRef] [PubMed]
[8] Kakavas, S., Kotsiou, O.S., Perlikos, F., et al. (2021) Pulmonary Function Testing in COPD: Looking beyond the Curtain of FEV1. NPJ Primary Care Respiratory Medicine, 31, 23-26. [Google Scholar] [CrossRef] [PubMed]
[9] 李凯旋. 血常规炎症指标对慢性阻塞性肺疾病急性加重期的诊断价值研究[D]: [硕士学位论文]. 太原: 山西医科大学, 2020.
[10] 曾廷武, 杜飞. 中性粒细胞功能在慢性阻塞性肺疾病患者中的变化及临床意义[J]. 吉林医学, 2020, 41(1): 35-37.
[11] Gao, J., Chen, B., Wu, S., et al. (2020) Blood Cell for the Differentiation of Airway Inflammatory Phenotypes in COPD Exacerbations. BMC Pulmonary Medi-cine, 20, Article No. 50. [Google Scholar] [CrossRef] [PubMed]
[12] Singh, D., Agusti, A., Anzueto, A., et al. (2019) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019. European Respiratory Journal, 53, Article ID: 1900164. [Google Scholar] [CrossRef] [PubMed]
[13] Zeiger, R.S., Tran, T.N., Butler, R.K., et al. (2018) Relation-ship of Blood Eosinophil Count to Exacerbations in Chronic Obstructive Pulmonary Disease. The Journal of Allergy and Clinical Immunology: In Practice, 6, 944-954.e5. [Google Scholar] [CrossRef] [PubMed]
[14] Mycroft, K., Krenke, R. and Górska, K. (2020) Eosinophils in COPD-Current Concepts and Clinical Implications. The Journal of Allergy and Clinical Immunology: In Practice, 8, 2565-2574. [Google Scholar] [CrossRef] [PubMed]
[15] 刘燕, 李红, 朱爱萍, 等. COPD患者CD4+/CD8+、CD8+CD28+T淋巴细胞检测意义[J]. 中华肺部疾病杂志(电子版), 2021, 14(5): 593-595.
[16] 宋永娜, 郭林青, 陈秋生, 等. 外周血细胞因子及T淋巴细胞水平与慢性阻塞性肺疾病严重程度的相关性[J]. 新乡医学院学报, 2021, 38(4): 332-336.
[17] 彭琴, 高伟良, 周海燕. NLR、脂联素、IL-6与慢性阻塞性肺疾病患者严重程度及肺功能的相关性[J]. 实用预防医学, 2023, 30(5): 600-603.
[18] 唐平平, 洪永青, 朱蓉, 等. 血清辅助性T淋巴细胞因子水平变化与COPD患者肺功能的关系[J]. 山东医药, 2022, 62(31): 11-14.
[19] 崔立慧, 李素娟, 陶建娇. COPD急性加重期患者血清水平变化及与肺功能的相关性[J]. 川北医学院学报, 2021, 36(11): 1516-1518+1540.
[20] 钱建德, 宦才娟. 不同分级慢性阻塞性肺疾病患者免疫功能、炎症因子水平及其与肺功能的关系分析[J]. 浙江医学, 2021, 43(13): 1435-1438+1443.
[21] 王景胜, 张立, 刘正君, 等. 慢性阻塞性肺疾病急性加重期患者血清SAA水平与肺功能、炎性因子的相关性及其诊断价值分析[J]. 现代生物医学进展, 2019, 19(22): 4330-4334.
[22] 李雪英, 胡苏萍, 陈国忠, 等. 炎症反应与慢性阻塞性肺疾病相关肺动脉高压及其血液高凝状态的关系[J]. 山东医药, 2017, 57(1): 71-73.
[23] Fermont, J.M., Masconi, K.L., Jensen, M.T., et al. (2019) Biomarkers and Clinical Outcomes in COPD: A Systematic Review and Meta-Analysis. Thorax, 74, 439-446. [Google Scholar] [CrossRef] [PubMed]
[24] 杨文漪, 王金湖, 曹季军, 等. COPD患者血清IL-6、CRP、血浆NT-proBNP与肺功能的相关性及其对病情的预测价值[J]. 检验医学与临床, 2020, 17(23): 3459-3462.
[25] Yoo, B., Lee, S.H., Kim, S.Y., et al. (2019) Relationship between Airway Obstruction and C-Reactive Protein Levels in a Community-Based Population of Korea. The International Journal of Tuberculosis and Lung Disease, 23, 1228- 1234. [Google Scholar] [CrossRef] [PubMed]
[26] 蒋凌志, 许丹媛, 杨志雄. 老年COPD患者血清PCT、hs-CRP的表达与肺功能指标、生活质量的相关性[J]. 中国老年学杂志, 2018, 38(7): 1623-1625.
[27] 全啊芳, 邹国英, 黄锡亮, 等. 老年COPD患者血清PCT及hs-CRP与肺功能指标的相关性研究[J]. 当代医学, 2020, 26(27): 164-165.
[28] Zuo, H., Xie, X., Peng, J., et al. (2019) Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Analytical Cellular Pa-thology, 2019, Article ID: 5189165. [Google Scholar] [CrossRef] [PubMed]
[29] 王翠莲, 周丽萍. NLR、PLR和SII对AECOPD并发肺动脉高压的预测价值[J]. 中外医学研究, 2020, 18(35): 63-65.
[30] Liu, X., Ge, H., Feng, X., et al. (2020) The Combination of Hemogram Indexes to Predict Exacerbation in Stable Chronic Obstructive Pulmonary Disease. Frontiers in Medicine, 7, Article ID: 572435. [Google Scholar] [CrossRef] [PubMed]
[31] Weiss, D.J., Segal, K., Casaburi, R., et al. (2021) Effect of Mes-enchymal Stromal Cell Infusions on Lung Function in COPD Patients with High CRP Levels. Respiratory Research, 22, Article No. 142. [Google Scholar] [CrossRef] [PubMed]