Smad3对Th17细胞分化与转分化的调控作用与机制
The Role and Mechanism of Smad3 in the Regulation of Th17 Cell Differentiation and Transdifferentiation
DOI: 10.12677/PI.2023.124039, PDF,   
作者: 刘思远, 戴 岳*：中国药科大学中药学院，江苏 南京
关键词: Th17细胞；Smad3；分化；转分化；Th17 Cell； Smad3； Differentiation； Transdifferentiation
摘要: Th17细胞属于效应T细胞亚群，能够保护机体免受外来病原体的侵害，维持组织的完整性，但其数目增多或过度活化可导致和加剧自身免疫性疾病。转化生长因子β (TGF-β)是诱导Th17细胞分化的重要细胞因子，但其经典下游信号分子Smad3可负性调节Th17细胞分化与功能，诱导Th17细胞转分化，提示TGF-β信号对Th17细胞分化具有复杂的作用。本文综述Smad3对Th17细胞分化及转分化的调控作用与机制，为构建靶向Th17细胞的新型治疗策略和药物开发提供参考。
Abstract: Th17 cells belong to a subset of effector T cells that protect the body from foreign pathogens and maintain tissue integrity, but their increased numbers or over-activation can cause and exacerbate autoimmune diseases. Transforming growth factor β (TGF-β) is an important cytokine that induces Th17 cell differentiation; however, its classical downstream signaling molecule Smad3 negatively regulates Th17 cell differentiation, inhibits Th17 cell function, and induces Th17 cell transdifferen-tiation, suggesting a complex role of TGF-β signaling on Th17 cell differentiation. This paper reviews the regulatory roles and mechanisms of Smad3 on Th17 cell differentiation and transdifferentiation, and provides a reference for the construction of novel therapeutic strategies targeting Th17 cells.
文章引用：刘思远, 戴岳. Smad3对Th17细胞分化与转分化的调控作用与机制[J]. 药物资讯, 2023, 12(4): 309-316. https://doi.org/10.12677/PI.2023.124039

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