MMP-1、MMP-7、MMP-9在特发性肺间质纤维化中的研究进展
Research Progress of MMP-1, MMP-7 and MMP-9 in Idiopathic Pulmonary Interstitial Fibrosis
DOI: 10.12677/ACM.2023.1371581, PDF,    科研立项经费支持
作者: 侯西苓:青海大学研究生院,青海 西宁;赵思雯:青海省人民医院呼吸与危重症医学科,青海 西宁
关键词: 特发性肺间质纤维化机制基质金属蛋白酶综述Idiopathic Pulmonary Interstitial Fibrosis Mechanism Matrix Metalloproteinases Review
摘要: 特发性肺纤维化(IPF)是一种病因不明的、发病机制复杂的、多信号通路参与的慢性进行性破坏性的肺部疾病。减缓这种疾病进展的唯一疗法为吡非尼酮和尼达尼布,但在降低死亡率方面并不完全预防或改善肺功能。目前的医学治疗方法不能完全有效地限制IPF患者的死亡率,迫切需要新的治疗方法。本文总结了MMP-1、MMP-7、MMP-9与特发性肺间质纤维化的关联,认为MMP-1、MMP-7、MMP-9对患者的诊治有一定指导意义。
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and destructive lung disease with un-known etiology, complex pathogenesis and multi-signaling pathway involvement. The only thera-pies to slow the progression of this disease, pirfenidone and Nidanib, do not completely prevent or improve lung function in terms of reducing mortality. Current medical treatments are not fully ef-fective in limiting mortality in patients with IPF, and new treatments are urgently needed. This ar-ticle summarizes the relationship between MMP-1, MMP-7, MMP-9 and idiopathic pulmonary inter-stitial fibrosis, and suggests that MMP-1, MMP-7, MMP-9 have certain guiding significance for the diagnosis and treatment of patients.
文章引用:侯西苓, 赵思雯. MMP-1、MMP-7、MMP-9在特发性肺间质纤维化中的研究进展[J]. 临床医学进展, 2023, 13(7): 11318-11323. https://doi.org/10.12677/ACM.2023.1371581

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