肝硬化失代偿患者TIPS术后再出血、并发症及生存率的影响研究
Study on the Effects of Recurrent Hemorrhage, Complications and Survival Rate after Transjugular Intrahepatic Portosystemic Shunt in Patients with Cirrhotic Portal Hypertension
DOI: 10.12677/ACM.2023.1371586, PDF,    科研立项经费支持
作者: 周 悠*, 沈严严：南华大学衡阳医学院附属南华医院，湖南省代谢相关脂肪性肝病临床研究中心，湖南 衡阳；南华大学衡阳医学院附属南华医院超声诊断科，湖南 衡阳 ；胡 章：南华大学衡阳医学院附属南华医院，湖南省代谢相关脂肪性肝病临床研究中心，湖南 衡阳；南华大学衡阳医学院附属南华医院介入血管外科，湖南 衡阳；阳学风#：南华大学衡阳医学院附属南华医院，湖南省代谢相关脂肪性肝病临床研究中心，湖南 衡阳；南华大学衡阳医学院附属南华医院全科医疗科，湖南 衡阳
关键词: 肝硬化门静脉高压失代偿患者；再出血；生存率；并发症；经颈静脉肝内门腔静脉分流术；Cirrhotic Patients with Decompensated Portal Hypertension； Rebleeding； Survival Rate； Complications； Transjugular Intrahepatic Portosystemic Shunt
摘要: 目的：探讨肝硬化门静脉高压失代偿患者经颈静脉肝内门腔静脉分流术(Transjugular Intrahepatic Portosystemic Shunt, TIPS)后再出血、并发症及生存率的影响。方法：选取2015年2月1日~2019年6月28日南华大学附属南华医院收治的130例肝硬化门静脉高压失代偿患者，随机分为对照组与观察组。对照组采用传统的保守治疗，观察组采用TIPS治疗。比较两组患者的再出血率、存活率以及并发症发生率。结果：随访结果表示，观察组再出血率为1.54%，低于对照组12.31% (P < 0.05)；随访6个月、12个月、18个月，观察组的存活率均高于对照组(P < 0.05)；观察组并发症的发生率(9.23%)低于对照组(20.00%, P < 0.05)。结论：TIPS可以有效提高肝硬化门静脉高压失代偿患者的存活率，降低再出血事件的发生，缓解腹水，降低门静脉高压，还能有效减少并发症的发生，安全高效，值得在临床推广使用。
Abstract: Objective: To investigate the effects of re-hemorrhage, complications and survival rate in patients with cirrhotic portal hypertension decompensated by transjugular Intrahepatic Portosystemic Shunt (TIPS). Methods: A total of 130 cirrhotic patients with portal hypertension decompensation admitted to Affiliated Nanhua Hospital of University of South China from February 1, 2015 to June 28, 2019 were selected. They were randomly divided into control group and observation group. The control group used traditional conservative treatment and the observation group was treated with TIPS. The rebleeding rate, survival rate, and complication rate were compared between the two groups. Results: The follow-up results showed that the rebleeding rate of the observation group was 1.54%, which was lower than that of the control group (12.31%) (P < 0.05). The follow-up period of 6 months, 12 months, and 18 months was higher than that of the control group (P < 0.05); The inci-dence of complications in the observation group (9.23%) was lower than that in the control group (20.00%, P < 0.05). Conclusion: TIPS can effectively improve the survival rate of patients with cir-rhotic portal hypertension decompensation, reduce the occurrence of rebleeding events, relieve as-cites, reduce portal hypertension, and effectively reduce the incidence of complications. It is safe and effective and worthy of clinical use.
文章引用：周悠, 胡章, 阳学风, 沈严严. 肝硬化失代偿患者TIPS术后再出血、并发症及生存率的影响研究[J]. 临床医学进展, 2023, 13(7): 11348-11353. https://doi.org/10.12677/ACM.2023.1371586

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