脂肪因子与急性胰腺炎的相关研究进展
Research Progress of Adipokine and Acute Pancreatitis
DOI: 10.12677/ACM.2023.1371624, PDF,  被引量   
作者: 李晨瑞, 李 笑：青海大学研究生院，青海 西宁；青海省人民医院普通外科，青海 西宁；刘林勋*：青海省人民医院普通外科，青海 西宁
关键词: 急性胰腺炎；脂肪因子；糖脂代谢；发病机制；Acute Pancreatitis； Adipokine； Glycolipid Metabolism； Pathogenesis
摘要: 脂肪因子是指主要由脂肪细胞分泌的生理活性因子，通过人体多种组织的糖脂代谢来进行调控反应，随着人体代谢功能的紊乱而产生相应的变化，与肥胖、心血管疾病、糖尿病、胰腺炎等代谢性疾病密切相关。但目前就脂肪因子与急性胰腺炎(acute pancreatitis, AP)疾病的相关性机制还没有形成广泛共识，本文就瘦素(Leptin)、血清抵抗素(Serum Resistin, SR)、脂联素(Adiponectin)、趋化素(Chemerin)、网膜素(Omentin)这几种新型脂肪因子与AP的疾病进展相关性予以综述。
Abstract: Adipokines are physiological active factors secreted mainly by adipocytes. They are regulated by glycolipid metabolism in various tissues of the human body. With the disorder of human metabolic function, corresponding changes are produced, which are closely related to obesity, cardiovascular disease, tumor metabolism, diabetes, pancreatitis and other metabolic diseases. However, there is currently no broad consensus on the mechanisms associated with pancreatitis (AP) pancreatitis. In this paper, Leptin, Serum Resistin, Adiponectin, Chemerin, Omentin, and several novel adipokines were correlated with the progression of AP.
文章引用：李晨瑞, 李笑, 刘林勋. 脂肪因子与急性胰腺炎的相关研究进展[J]. 临床医学进展, 2023, 13(7): 11609-11614. https://doi.org/10.12677/ACM.2023.1371624

参考文献

[1] 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021) [J]. 中华外科杂志, 2021, 59(7): 578-587.
[2] Kumari, R., Kumar, S. and Kant, R. (2019) An Update on Metabolic Syndrome: Metabolic Risk Markers and Adipokines in the Development of Metabolic Syndrome. Diabetes & Metabolic Syndrome: Clinical Research & Re-views, 13, 2409-2417. [Google Scholar] [CrossRef] [PubMed]
[3] Karpavicius, A., Dambrauskas, Z. and Gradauskas, A. (2016) The Clinical Value of Adipokines in Predicting the Severity and Outcome of Acute Pancreatitis. BMC Gastroenterology, 16, Article No. 99. [Google Scholar] [CrossRef] [PubMed]
[4] Adiyaman, S.C., Ozer, M. and Saydam, B.O. (2020) The Role of Adiponectin in Maintaining Metabolic Homeostasis. Current Diabetes Reviews, 16, 95-103. [Google Scholar] [CrossRef] [PubMed]
[5] Wos-Wroniewicz, E., Caban, M. and Malecka-Panas, E. (2020) Role of Adipokines in the Assessment of Severity and Predicting the Clinical Course of Acute Pancreatitis. Journal of Physiology and Pharmacology, 71, 605-614.
[6] Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M. (1995) Positional Cloning of the Mouse Obese Gene and Its Human Homologue. Nature, 374, 479-479. [Google Scholar] [CrossRef] 
[7] Francisco, V., Pino, J., Campos-Cabaleiro, V., et al. (2018) Obe-sity, Fat Mass and Immune System: Role for Leptin. Frontiers in Physiology, 9, Article 640. [Google Scholar] [CrossRef] [PubMed]
[8] Villasís-Keever, M.A., Zurita-Cruz, J.N., Serret-Montoya, J., et al. (2022) Leptin Receptor and Prolactin in Pubertal Disorders and Chronic Kidney Disease. Pediatrics International, 64, e15183. [Google Scholar] [CrossRef] [PubMed]
[9] Zhou, Y. and Rui, L. (2013) Leptin Signaling and Leptin Re-sistance. Frontiers of Medicine, 7, 207-222. [Google Scholar] [CrossRef] [PubMed]
[10] Konturek, P.C., Konturek, S.J., Brzozowski, T., Jaworek, J. and Hahn, E.G. (2001) Role of Leptin in the Stomach and the Pancreas. Journal of Physiology, 95, 345-354. [Google Scholar] [CrossRef] 
[11] Zyromski, N.J., Mathur, A. and Pitt, H.A. (2008) A Murine Model of Obesity Implicates the Adipokine Milieu in the Pathogenesis of Severe Acute Pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 295, G552-G558. [Google Scholar] [CrossRef] [PubMed]
[12] Steppan, C.M., Bailey, S.T., Bhat, S., et al. (2001) The Hormone Resistin Links Obsity to Diabetes. Nature, 409, 307-312. [Google Scholar] [CrossRef] [PubMed]
[13] Su, X. and Peng, D. (2020) Adipokines as Novel Biomarkers of Cardio-Metabolic Disorders. Clinica Chimica Acta, 507, 31-38. [Google Scholar] [CrossRef] [PubMed]
[14] Juan-Pablo, I., Shults, J.A. and Curtis, B.J. (2019) Alcohol Intoxi-cation and the Postburn Gastrointestinal Hormonal Response. Journal of Burn Care & Research, 40, 785-791.
[15] Sassek, M., Pruszynska-Oszmalek, E., Kołodziejski, P.A., et al. (2016) Resistin Is Produced by Rat Pan-creatic Islets and Regulates Insulin and Glucagon in Vitro Secretion. Islets, 8, 177-185. [Google Scholar] [CrossRef] [PubMed]
[16] Kibar, Y.İ., Albayrak, F., Arabul, M., Dursun, H., Albayrak, Y. and Ozturk, Y. (2016) Resistin: New Serum Marker for Predicting Severity of Acute Pancreatitis. Journal of Interna-tional Medical Research, 44, 328-337. [Google Scholar] [CrossRef] [PubMed]
[17] Singh, A., Dawra, S., Rana, S., et al. (2021) Can Serum Resistin Predict Severity of Acute Pancreatitis? Biomarkers, 26, 31-37. [Google Scholar] [CrossRef] 
[18] Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. and Lodish, H.F. (1995) A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes. Journal of Biological Chemistry, 270, 26746-26749. [Google Scholar] [CrossRef] [PubMed]
[19] Parida, S., Siddharth, S. and Sharma, D. (2019) Adiponectin, Obe-sity and Cancer: Clash of the Bigwigs in Health and Disease. International Journal of Molecular Sciences, 20, Article 2519. [Google Scholar] [CrossRef] [PubMed]
[20] Liu, H. (2020) Adiponectin Peptide Alleviates Oxidative Stress and NLRP3 Inflammasome Activation after Cerebral Ischemia-Reperfusion Injury by Regulating AMPK/GSK-3β. Ex-perimental Neurology, 329, Article ID: 113302. [Google Scholar] [CrossRef] [PubMed]
[21] Moon, H.U., Ha, K.H., Han, S.J., Kim, H.J. and Kim, D.J. (2019) The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction. Journal of Ko-rean Medical Science, 34, e7. [Google Scholar] [CrossRef] [PubMed]
[22] Jian, L., Su, Y.X. and Deng, H.C. (2013) Adiponectin-Induced Inhi-bition of Intrinsic and Extrinsic Apoptotic Pathways Protects Pancreatic β-Cells Against Apoptosis. Hormone & Meta-bolic Research, 45, 561-566. [Google Scholar] [CrossRef] [PubMed]
[23] Kim, H., Kang, J., Jung, D., Kang, B.-T., Chang, D. and Yang, M.-P. (2021) A Preliminary Evaluation of the Circulating Leptin/Adiponectin Ratio in Dogs with Pituitary-Dependent Hypera-drenocorticism and Concurrent Diabetes Mellitus. Domestic Animal Endocrinology, 74, Article ID: 106506. [Google Scholar] [CrossRef] [PubMed]
[24] Gantz, I., Konda, Y., Yang, Y.K., Miller, D.E., Dierick, H.A. and Yamada, T. (1996) Molecular Cloning of a Novel Receptor (CMKLR1) with Homology to the Chemotactic Factor Receptors. Cytogenetic & Genome Research, 74, 286-290. [Google Scholar] [CrossRef] [PubMed]
[25] Nagpal, S., Patel, S., Jacobe, H., et al. (1997) Tazarotene-Induced Gene 2 (TIG2), a Novel Retinoid-Responsive Gene in Skin. Journal of Investigative Dermatology, 109, 91-95. [Google Scholar] [CrossRef] [PubMed]
[26] Wittamer, V., Franssen, J.D., Vulcano, M., et al. (2003) Specific Recruitment of Antigen-Presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids. Journal of Experimental Medicine, 198, 977-985. [Google Scholar] [CrossRef] [PubMed]
[27] Bozaoglu, K., Bolton, K., McMillan, J., Zimmet, P., Jowett, J., Collier, G., Walder, K. and Segal, D. (2007) Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome. Endocrinology, 148, 4687-4694. [Google Scholar] [CrossRef] [PubMed]
[28] Zabel, B.A., Allen, S.J., Kulig, P., et al. (2005) Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades. Journal of Biological Chemistry, 280, 34661-34666. [Google Scholar] [CrossRef] 
[29] İnci, S., Aksan, G. and Doğan, P. (2016) Chemerin as an Independ-ent Predictor of Cardiovascular Event Risk. Therapeutic Advances in Endocrinology and Metabolism, 7, 57-68. [Google Scholar] [CrossRef] [PubMed]
[30] Banas, M., Zegar, A., Kwitniewski, M., et al. (2015) The Expres-sion and Regulation of Chemerin in the Epidermis. B. Ryffel. PLOS ONE, 10, e0117830. [Google Scholar] [CrossRef] [PubMed]
[31] Jaworek, J., Szklarczyk, J. and Kot, M. (2019) Chemerin Alle-viates Acute Pancreatitis in the Rat thorough Modulation of NF-κB Signal. Pancreatology, 19, 401-408. [Google Scholar] [CrossRef] [PubMed]
[32] Yang, R.Z., Lee, M.J., Hu, H., et al. (2006) Identification of Omen-tin as a Novel Depot-Specific Adipokine in Human Adipose Tissue: Possible Role in Modulating Insulin Action. Ameri-can Journal of Physiology-Endocrinology and Metabolism, 290, 1253-1261. [Google Scholar] [CrossRef] [PubMed]
[33] Watanabe, T., Watanabe-Kominato, K., Takahashi, Y., Kojima, M. and Watanabe, R. (2017) Adipose Tissue-Derived Omentin-1 Function and Regulation. Comprehensive Physiology, 7, 765-781. [Google Scholar] [CrossRef] [PubMed]
[34] Menzel, J., et al. (2016) Omentin-1 and Risk of Myocardial Infarction and Stroke: Results from the EPIC-Potsdam Cohort Study. Atherosclerosis, 251, 415-421. [Google Scholar] [CrossRef] [PubMed]
[35] Sit, M., Aktas, G., Yilmaz, E.E., Alcelik, A., Terzi, E.H. and Tosun, M. (2014) Effects of the Inflammatory Response on Serum Omentin Levels in Early Acute and Chronic Pan-creatitis. Clinical Therapeutics, 165, e148-e152.
[36] Karpavicius, A., Dambrauskas, Z. and Sileikis, A. (2012) Value of Adipokines in Predicting the Severity of Acute Pancreatitis: Comprehensive Review. World Journal of Gastroenterology, 18, 6620-6627. [Google Scholar] [CrossRef] [PubMed]

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