正念疗法对维持性血液透析患者焦虑、抑郁及睡眠质量影响的Meta分析

Meta-Analysis of Effects of Mindfulness Therapy on Anxiety, Depression and Sleep Quality of Maintenance Hemodialysis Patients

摘要: 目的：系统评价正念疗法干预对维持性血液透析患者焦虑、抑郁及睡眠质量的影响。方法：计算机检索中国生物医学文献数据库、中国知网、万方数据库、维普数据库、PubMed、The Cochrane Library、Embase、Web of Science发表的基于正念干预维持性血液透析患者人群焦虑、抑郁及睡眠质量的临床随机对照试验，检索时间为建库至2022年6月。采用RevMan 5.3软件进行数据合成与分析。结果：最终纳入10篇文献，其中中文文献9篇，英文文献1篇，样本量合计1162例。Meta分析结果显示：与常规护理相比，基于正念疗法的干预能改善维持性血液透析患者的睡眠质量[MD = −1.47, 95%CI (−5.51~−2.84), P < 0.001]，有效缓解维持性血液透析患者的焦虑情绪[SMD = −1.51, 95%CI (−1.83~−1.20), P < 0.001]、抑郁情绪[SMD = −1.67, 95%CI (−1.97~−1.37), P < 0.001]。结论：正念疗法可以改善维持性血液透析患者的睡眠质量，并缓解其焦虑和抑郁情绪。

Abstract: Objective: To systematically evaluate the effects of mindfulness therapy intervention on anxiety, depression and sleep quality in maintenance hemodialysis patients. Methods: We searched CNKI, Wanfang database, VIP database, Chinese biomedical literature database, PubMed, The Cochrane Library, Embase, and Web of Science, which were retrieved from the establishment of database to June 2022 for the randomized controlled clinical trial based on mindfulness intervention for anxie-ty, depression, and sleep quality in maintenance hemodialysis patients. RevMan 5.3 software was used for data synthesis and analysis. Results: Ten literatures were included, including 9 Chinese literatures and 1 English literature, with a total sample size of 1162 cases. The results of Me-ta-analysis showed that: Mindfulness based intervention improved sleep quality in maintenance hemodialysis patients compared with conventional care [MD = −1.47, 95%CI (−5.51~−2.84), P < 0.001], effective in relieving anxiety of patients with maintenance hemodialysis [SMD = 1.51, 95%CI (1.83~1.20), P < 0.001], depression [SMD = 1.67, 95%CI (1.97~1.37), P < 0.001)]. Conclusion: Mind-fulness therapy can improve sleep quality and relieve anxiety and depression in maintenance he-modialysis patients.