MiR-30e在心血管疾病中的研究进展

Research Progress of MiR-30e in Cardiovascular Disease

摘要: 根据美国心脏病协会(American Heart Association on Heart Disease and Stroke)的数据统计。全球范围内每年大约有1730万人死于心血管疾病及相关并发症，并且这个数字还在逐年增加。miRNA的发现和研究为诊断和治疗心血管疾病(cardiovascular disease, CVD)提供了新的思路。目前已知的人类miRNA有3000个以上，最初的分析推测其可调控人类至少三分之一的编码基因。也就是说miRNA为多种疾病的诊断、治疗及预后提供了潜在靶点。MicroRNAs (miRNAs)是由RNA聚合酶II (Pol II)转录的初级miRNA (primiRNA)产生的约22个核苷酸的小RNA家族。Mir-30家族是miRNA家族中的一个重要成员，由Mir-30a、Mir-30b、Mir-30c、Mir-30d和Mir-30e组成，Mir-30c又分为Mir-30c-1和Mir-30c-2，由位于人类染色体1、6和8的6个基因编码。

Abstract: According to the American Heart Association, Globally, approximately 17.3 million people die from cardiovascular disease and related complications each year, and this number is increasing every year. miRNA discovery and research provide new ideas for the diagnosis and treatment of cardio-vascular disease (CVD). There are currently more than 3000 known human miRNAs, and initial analyses have hypothesized that they regulate at least one-third of the genes encoded in humans. This means that miRNAs provide potential targets for the diagnosis, treatment and prognosis of a variety of diseases. microRNAs (miRNAs) are small RNA families of approximately 22 nucleotides produced by primary miRNAs (primiRNAs) transcribed by RNA polymerase II (Pol II). The Mir-30 family is an important member of the miRNA The Mir-30 family is an important member of the miRNA family, consisting of Mir-30a, Mir-30b, Mir-30c, Mir-30d, and Mir-30e, with Mir-30 30c is di-vided into Mir-30c-1 and Mir-30c-2, which are encoded by six genes located on human chromo-somes 1, 6 and 8.