热疗对肿瘤微环境及免疫治疗影响的研究进展

Research Progress on the Effect of Hyperthermia on Tumor Microenvironment and Immunotherapy

摘要: 近年来，放化疗仍然是肿瘤治疗的不可或缺的手段，然而肿瘤细胞产生放化疗原发性或者继发性耐受往往是癌症治疗失败的主要原因。热疗在临床应用中显示具有无毒、安全、耐受性好等优势，其不仅对放化疗增敏，而且与肿瘤免疫及微环境相关机制密切相关，热疗不仅可以改变肿瘤生存和生长所必需的因素，如肿瘤微环境(Tumor Microenvironment)、免疫反应、血管形成和供氧，而且也可以通过调节肿瘤免疫环境中相关蛋白表达、细胞因子来调节免疫环境发挥杀死肿瘤细胞的作用。随着肿瘤诊疗研究的深入，热疗影响免疫治疗的机制及其在临床上的应用引起了关注，并成为一个新的研究领域。本文将肿瘤热疗与放化疗、肿瘤免疫及微环境和免疫治疗之间的研究进展作一综述。

Abstract: In recent years, chemoradiotherapy is still an indispensable means for tumor treatment. However, primary or secondary tolerance to chemoradiotherapy produced by tumor cells is often the main reason for the failure of cancer treatment. Hyperthermia is called green therapy because it is non-toxic, safe and well-tolerated in clinical application. It not only increases the sensitivity to chemora-diotherapy, but also is closely related to the related mechanisms of tumor immunity and microen-vironment. Hyperthermia can not only change the factors necessary for tumor survival and growth, such as tumor microenvironment, immune response, angiogenesis and oxygen supply, but also reg-ulate the immune environment to play the role of killing tumor cells by regulating the expression of related proteins and cytokines in the tumor immune environment. With the deepening of tumor research, the mechanism of immunotherapy by tumor hyperthermia and its clinical application have attracted people’s interest and become a new research field. In this paper, we review the ad-vances in the study of the relationship between hyperthermia, chemoradiotherapy, tumor micro-environment and immunotherapy.