LncRNA在肿瘤转移和侵袭中的研究现状

Research Status of LncRNA in Tumor Metastasis and Invasion

摘要: 长非编码RNA (Long non-coding RNA)是一类基因长度超过200个核苷酸的非编码RNA。近年来，随着二代测序技术的发展以及对人们对LncRNA的深入研究，发现了LncRNA通过作为肿瘤的癌基因或抑制因子发挥着双重作用，即促进肿瘤或者抑制肿瘤。LncRNA现已被证明参与各种生物过程，如细胞生长、抗凋亡、转移和侵袭。最近许多研究发现LncRNA在各种恶性肿瘤中显著异常表达，包括肝癌、胰腺癌、胃癌和肺癌等。本文综述将从在国内外研究中LncRNA与肿瘤的转移和侵袭等生物学行为以及预后作一概述，以期为这些肿瘤提供新治疗的思路。

Abstract: Long non-coding RNA (LncRNA) is a class of non-coding RNAs with a gene length of more than 200 nucleotides. In recent years, with the development of second-generation sequencing technology and in-depth studies on LncRNA, it has been found that LncRNA plays a dual role as an oncogene or suppressor of tumor, that is, promoting tumor or inhibiting tumor. LncRNAs have now been shown to be involved in various biological processes, such as cell growth, anti-apoptosis, metastasis, and invasion. Recently, many studies have found that LncRNA is significantly and abnormally expressed in various malignant tumors, including liver cancer, pancreatic cancer, gastric cancer and lung can-cer. This review will summarize the relationship between LncRNA and tumor metastasis, invasion and other biological behaviors as well as prognosis in domestic and foreign studies, in order to pro-vide new treatment ideas for these tumors.