乳腺癌患者腋窝淋巴结转移评估和诊疗策略研究进展
Research Progress on Evaluation and Treat-ment Strategy of Axillary Lymph Node Metastasis in Breast Cancer Patients
DOI: 10.12677/ACM.2023.1371709, PDF,   
作者: 罗文培, 蒋乾坤, 杨 露：重庆医科大学附属第二医院乳腺甲状腺外科，重庆
关键词: 乳腺癌；腋窝淋巴结；前哨淋巴结；淋巴结清扫；Breast Cancer； Axillary Lymph Node； Sentinel Lymph Node； Lymph Node Dissection
摘要: 乳腺癌外科治疗理念在转变，在适合患者情况的前提下应避免更多的侵入性操作。有一些研究证实了前哨淋巴结活检(Sentinel lymph node biopsy, SLNB)结果为阳性的患者豁免腋窝淋巴结清扫(Axillary lymph node dissection, ALND)的安全性，本研究的目的是系统地回顾文献，分析乳腺癌患者腋窝淋巴结转移(Axillary lymph node metastasis, ALNM)的评估和诊疗现状，并对其前沿进展作一综述。
Abstract: The concept of surgical treatment of breast cancer is changing, and more invasive procedures should be avoided under the premise of appropriate patient conditions. Several studies have con-firmed the safety of exempting Axillary lymph node dissection (ALND) in patients with positive Sen-tinel node biopsy (SLNB) results. The purpose of this study was to systematically review the litera-ture and analyze the current status of evaluation, diagnosis and treatment of Axillary lymph node metastasis (ALNM) in patients with breast cancer. The advances in this field are also summarized.
文章引用：罗文培, 蒋乾坤, 杨露. 乳腺癌患者腋窝淋巴结转移评估和诊疗策略研究进展[J]. 临床医学进展, 2023, 13(7): 12209-12213. https://doi.org/10.12677/ACM.2023.1371709

参考文献

[1] Tan, L., Mai, D., Zhang, B., et al. (2019) PIWI-Interacting RNA-36712 Restrains Breast Cancer Progression and Chemoresistance by Interaction with SEPW1 Pseudogene SEPW1P RNA. Molecular Cancer, 18, 9. [Google Scholar] [CrossRef] [PubMed]
[2] Tian, W., Yao, Y., Fan, G., et al. (2019) Changes in Lipid Profiles during and after (Neo)adjuvant Chemotherapy in Women with Early-Stage Breast Cancer: A Retrospective Study. PLOS ONE, 14, e0221866. [Google Scholar] [CrossRef] [PubMed]
[3] Hwang, S.O., Lee, S.W., Kim, H.J., et al. (2013) The Compara-tive Study of Ultrasonography, Contrast-Enhanced MRI, and (18)F-FDG PET/CT for Detecting Axillary Lymph Node Metastasis in T1 Breast Cancer. Journal of Breast Cancer, 16, 315-321. [Google Scholar] [CrossRef] [PubMed]
[4] Li, Z.Y., Zhang, Z., Cao, X.Z., et al. (2020) Platinum-Based Neo-adjuvant Chemotherapy for Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis. Journal of Interna-tional Medical Research, 48. [Google Scholar] [CrossRef] [PubMed]
[5] Von Minckwitz, G., Schneeweiss, A., Loibl, S., et al. (2014) Ne-oadjuvant Carboplatin in Patients with Triple-Negative and HER2-Positive Early Breast Cancer (GeparSixto; GBG 66): A Randomised Phase 2 Trial. The Lancet Oncology, 15, 747-756. [Google Scholar] [CrossRef] 
[6] Song, Y.X., Xu, Z., Liang, M.X., et al. (2022) Diagnostic Accuracy of De-Escalated Surgical Procedure in Axilla for Node-Positive Breast Cancer Patients Treated with Neoadju-vant Systemic Therapy: A Systematic Review and Meta-Analysis. Cancer Medicine, 11, 4085-4103. [Google Scholar] [CrossRef] [PubMed]
[7] Krag, D.N. anderson, S.J., Julian, T.B., et al. (2010) Sentinel-Lymph-Node Resection Compared with Conventional Axillary-Lymph-Node Dissection in Clinically Node-Negative Patients with Breast Cancer: Overall Survival Findings from the NSABP B-32 Randomised Phase 3 Trial. The Lancet Oncology, 11, 927-933. [Google Scholar] [CrossRef] 
[8] Kim, H., Lee, S.B., Nam, S.J., et al. (2021) Survival of Breast-Conserving Surgery plus Radiotherapy versus Total Mastectomy in Early Breast Cancer. Annals of Surgical On-cology, 28, 5039-5047. [Google Scholar] [CrossRef] [PubMed]
[9] Ge, I., Erbes, T. and Juhasz-Boss, I. (2022) Prognostic Value and Management of Regional Lymph Nodes in Locoregional Breast Cancer Recurrence: A Systematic Review of the Lit-erature. Archives of Gynecology and Obstetrics, 306, 943-957. [Google Scholar] [CrossRef] [PubMed]
[10] Voogd, A.C., Coebergh, J.W., Repelaer Van Driel, O.J., et al. (2000) The Risk of Nodal Metastases in Breast Cancer Patients with Clinically Negative Lymph Nodes: A Popula-tion-Based Analysis. Breast Cancer Research and Treatment, 62, 63-69. [Google Scholar] [CrossRef] 
[11] Pezner, R.D., Patterson, M.P., Hill, L.R., et al. (1986) Arm Lymphedema in Patients Treated Conservatively for Breast Cancer: Relationship to Patient Age and Axillary Node Dis-section Technique. International Journal of Radiation Oncology, Biology, Physics, 12, 2079-2083. [Google Scholar] [CrossRef] [PubMed]
[12] Haigh, P.I., Hsueh, E.C. and Giuliano, A.E. (1999) Sentinel Lymphadenectomy in Breast Cancer. Breast Cancer, 6, 139-144. [Google Scholar] [CrossRef] 
[13] Zhou, Y., Pu, S., Jiang, S., et al. (2022) The Prognostic Significance of Further Axillary Dissection for Sentinel Lymph Node Micrometastases in Female Breast Cancer: A Competing Risk Analysis Using the SEER Database. Frontiers in Oncolo-gy, 12, Article ID: 1012646. [Google Scholar] [CrossRef] [PubMed]
[14] Mcmasters, K.M., Giuliano, A.E., Ross, M.I., et al. (1998) Sentinel-Lymph-Node Biopsy for Breast Cancer—Not Yet the Standard of Care. The New Eng-land Journal of Medicine, 339, 990-995. [Google Scholar] [CrossRef] 
[15] Giuliano, A.E., Jones, R.C., Brennan, M., et al. (1997) Sen-tinel Lymphadenectomy in Breast Cancer. Journal of Clinical Oncology, 15, 2345-2350. [Google Scholar] [CrossRef] 
[16] Mcmasters, K.M., Tuttle, T.M., Carlson, D.J., et al. (2000) Sen-tinel Lymph Node Biopsy for Breast Cancer: A Suitable Alternative to Routine Axillary Dissection in Multi-Institutional Practice When Optimal Technique Is Used. Journal of Clinical Oncology, 18, 2560-2566. [Google Scholar] [CrossRef] 
[17] Veronesi, U., Paganelli, G., Viale, G., et al. (2003) A Random-ized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer. The New England Journal of Medicine, 349, 546-553. [Google Scholar] [CrossRef] 
[18] Krag, D.N. anderson, S.J., Julian, T.B., et al. (2007) Technical Out-comes of Sentinel-Lymph-Node Resection and Conventional Axillary-Lymph-Node Dissection in Patients with Clinically Node-Negative Breast Cancer: Results from the NSABP B-32 Randomised Phase III Trial. The Lancet Oncology, 8, 881-888. [Google Scholar] [CrossRef] 
[19] Crane-Okada, R., Wascher, R.A., Elashoff, D., et al. (2008) Long-Term Morbidity of Sentinel Node Biopsy versus Complete Axillary Dissection for Unilateral Breast Cancer. An-nals of Surgical Oncology, 15, 1996-2005. [Google Scholar] [CrossRef] [PubMed]
[20] Purushotham, A.D., Upponi, S., Klevesath, M.B., et al. (2005) Morbidity after Sentinel Lymph Node Biopsy in Primary Breast Cancer: Results from a Randomized Controlled Trial. Journal of Clinical Oncology, 23, 4312-4321. [Google Scholar] [CrossRef] 
[21] Dihge, L., Bendahl, P.O. and Ryden, L. (2017) Nomograms for Preoperative Prediction of Axillary Nodal Status in Breast Cancer. British Journal of Surgery, 104, 1494-1505. [Google Scholar] [CrossRef] [PubMed]
[22] Shoup, M., Malinzak, L., Weisenberger, J., et al. (1999) Predictors of Axil-lary Lymph Node Metastasis in T1 Breast Carcinoma. The American Surgeon, 65, 748-752. [Google Scholar] [CrossRef] 
[23] Bevilacqua, J.L., Kattan, M.W., Fey, J.V., et al. (2007) Doctor, What Are My Chances of Having a Positive Sentinel Node? A Validated Nomogram for Risk Estimation. Journal of Clinical Oncology, 25, 3670-3679. [Google Scholar] [CrossRef] 
[24] Hindié, E., Groheux, D., Brenot-Rossi, I., et al. (2011) The Senti-nel Node Procedure in Breast Cancer: Nuclear Medicine as the Starting Point. Journal of Nuclear Medicine, 52, 405-414. [Google Scholar] [CrossRef] [PubMed]
[25] Schwartz, G.F., Giuliano, A.E., Veronesi, U., et al. (2002) Pro-ceedings of the Consensus Conference on the Role of Sentinel Lymph Node Biopsy in Carcinoma of the Breast, April 19-22, 2001, Philadelphia, Pennsylvania. Cancer, 94, 2542-2551. [Google Scholar] [CrossRef] [PubMed]
[26] Lyman, G.H., Temin, S., Edge, S.B., et al. (2014) Sentinel Lymph Node Biopsy for Patients with Early-Stage Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. Journal of Clinical Oncology, 32, 1365-1383. [Google Scholar] [CrossRef] 
[27] Montgomery, L.L., Thorne, A.C., Van Zee, K.J., et al. (2002) Isosulfan Blue Dye Reactions during Sentinel Lymph Node Mapping for Breast Cancer. Anesthesia & Analgesia, 95, 385-388. [Google Scholar] [CrossRef] 
[28] Barthelmes, L., Goyal, A., Newcombe, R.G., et al. (2010) Adverse Reactions to Patent Blue V Dye—The NEW START and ALMANAC Experience. European Journal of Surgical Oncology, 36, 399-403. [Google Scholar] [CrossRef] [PubMed]
[29] Gentilini, O. and Veronesi, U. (2012) Abandoning Sentinel Lymph Node Biopsy in Early Breast Cancer? A New Trial in Progress at the European Institute of Oncology of Milan (SOUND: Sentinel Node vs Observation after Axillary Ultrasound). Breast, 21, 678-681. [Google Scholar] [CrossRef] [PubMed]
[30] Tavassoli, F.A., Devilee, P., et al. (2003) Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC, Lyon.
[31] Wang, J., Mittendorf, E.A., Sahin, A.A., et al. (2014) Outcomes of Sentinel Lymph Node Dissection Alone vs. Axillary Lymph Node Dissection in Early Stage Inva-sive Lobular Carcinoma: A Retrospective Study of the Surveillance, Epidemiology and End Results (SEER) Database. PLOS ONE, 9, e89778. [Google Scholar] [CrossRef] [PubMed]
[32] Donker, M., Van Tienhoven, G., Straver, M.E., et al. (2014) Radiotherapy or Surgery of the Axilla after a Positive Sentinel Node in Breast Cancer (EORTC 10981-22023 AMAROS): A Randomised, Multicentre, Open-Label, Phase 3 Non-Inferiority Trial. The Lancet Oncology, 15, 1303-1310. [Google Scholar] [CrossRef] 
[33] Fisher, C.S., Margenthaler, J.A., Hunt, K.K., et al. (2020) The Landmark Series: Axillary Management in Breast Cancer. Annals of Surgical Oncology, 27, 724-729. [Google Scholar] [CrossRef] [PubMed]
[34] Houssami, N., Ciatto, S., Turner, R.M., et al. (2011) Preopera-tive Ultrasound-Guided Needle Biopsy of Axillary Nodes in Invasive Breast Cancer: Meta-Analysis of Its Accuracy and Utility in Staging the Axilla. Annals of Surgery, 254, 243-251. [Google Scholar] [CrossRef] 
[35] Wu, J., Zhang, H., Li, L., et al. (2020) A Nomogram for Predicting Overall Survival in Patients with Low-Grade Endometrial Stromal Sarcoma: A Population-Based Analysis. Cancer Communications (Lond), 40, 301-312. [Google Scholar] [CrossRef] [PubMed]

为你推荐