中药调节中性粒细胞治疗类风湿关节炎研究进展
Advances in Research on Rheumatoid Arthritis in Chinese Medicine Regulation
DOI: 10.12677/TCM.2023.127271, PDF,    科研立项经费支持
作者: 罗书曼, 朱 星, 陈云志, 陈 帅：贵州中医药大学基础医学院，贵州 贵阳；曾凡勇, 周 艳, 何昌禄*：德江县民族中医院推拿科，贵州 铜仁
关键词: 类风湿关节炎；中药；中性粒细胞；中性粒细胞胞外诱捕网；细胞因子；Rheumatoid Arthritis； Chinese Herbal； Neutrophil； Neutrophil Extracellular Traps； NETs； Cytokine
摘要: 类风湿关节炎(Rheumatoid Arthritis, RA)是以持续性反复发作的关节滑膜炎症为病理特征的慢性系统性自身免疫疾病，该病治愈率低且易反复，由于发病机制不明，临床上并无特效药。系统性自身免疫疾病是由于免疫损伤导致全身多器官损害。因此，调节机体异常的免疫反应是针对RA治疗的关键点。中性粒细胞作为人体主要的免疫细胞之一，通过分泌多种细胞因子在RA的病理过程中发挥了重要作用。近年来中药通过调节中性粒细胞活性治疗RA成为新的研究方向。
Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent recurrent synovial inflammation. The cure rate of rheumatoid arthritis (RA) is low and easy to repeat. Because the pathogenesis is unknown, there is no specific drug in clinic. Systemic autoimmune diseases are caused by immune damage that causes multiple organ damage throughout the body. Therefore, regulating the abnormal immune response of the body is the key point for RA treatment. Neutrophils, as one of the main immune cells in human body, play an important role in the pathological process of RA by secreting many cytokines. In recent years, traditional Chinese medicine has become a new research direction in the treatment of RA by regulating neutrophil activity.
文章引用：罗书曼, 朱星, 陈云志, 陈帅, 曾凡勇, 周艳, 何昌禄. 中药调节中性粒细胞治疗类风湿关节炎研究进展[J]. 中医学, 2023, 12(7): 1816-1821. https://doi.org/10.12677/TCM.2023.127271

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