脓毒症合并急性肾损伤的发病机制与最新治疗进展的研究
Research on the Pathogenesis and Recent Treatment Progress of Sepsis Combined with Acute Kidney Injury
DOI: 10.12677/ACM.2023.1381733, PDF,  被引量    科研立项经费支持
作者: 王含玉, 罗朋立*：青海大学高原医学研究中心，高原医学教育部重点实验室，青海省高原医学应用基础重点实验室，青海–犹他高原医学联合重点实验室，青海 西宁
关键词: 脓毒症；脓毒症合并急性肾损伤；脓毒症休克；炎症；Sepsis； Sepsis Associated with Acute Kidney Injury； Septic Shock； Inflammation
摘要: 脓毒症合并急性肾损伤(S-AKI)是住院和危重患者常见的危及生命的并发症。S-AKI使住院死亡率增加6到8倍，患慢性肾脏病(CKD)的风险增加三倍。S-AKI的早期出现限制了预防性干预的影响，但为专注于逆转细胞损伤和促进适应性修复的治疗策略的发展打开了大门。为了适应这种变化，需要更好地理解脓毒症时肾小管上皮细胞(TEC)损伤的机制以及炎症反应，代谢重编程等。本文简要描述了目前对S-AKI的理解，以及其病理生理学的发展。
Abstract: Sepsis associated with acute kidney injury (S-AKI) is a common life-threatening complication in hospitalized and critically ill patients. S-AKI increased in-hospital mortality 6- to 8-fold and 3-fold the risk of chronic kidney disease (CKD). The early emergence of S-AKI limits the impact of preven-tive interventions, but opens the door to the development of therapeutic strategies focused on re-versing cell damage and promoting adaptive repair. In order to adapt to this change, it is necessary to better understand the mechanism of renal tubular epithelial cell (TEC) injury in sepsis as well as the inflammatory response, metabolic reprogramming, etc. This paper briefly describes the current understanding of S-AKI, and the development of its pathophysiology.
文章引用：王含玉, 罗朋立. 脓毒症合并急性肾损伤的发病机制与最新治疗进展的研究[J]. 临床医学进展, 2023, 13(8): 12362-12368. https://doi.org/10.12677/ACM.2023.1381733

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