八段锦联合常规治疗干预慢性心力衰竭患者疗效的Meta分析

Meta-Analysis of the Efficacy of Baduanjin Combined with Conventional Therapy in Patients with Chronic Heart Failure

摘要: 目的：对八段锦联合常规治疗干预的慢性心力衰竭患者的疗效进行系统评价。方法：检索中国生物医学文献数据库(CBM)、知网(CNKI)等中文数据库及Cochrane Library、PubMed等英文数据库的八段锦联合常规治疗干预慢性心力衰竭患者的随机对照试验(RCT)，检索时间为建库至2021年12月，使用物理治疗证据数据库量表(PEDro量表)对文章进行质量评估，并运用RevMan5.3软件对数据进行Meta分析。结果：最终纳入中文文献共15篇。Meta分析结果显示进行八段锦运动的左室射血分数(LVEF) [MD = 2.40, 95%CI (1.52, 3.28), Z = 5.35, P < 0.00001]，差异有统计学意义，异质性检验(P = 0.10, I2 = 41%)。其6分钟步行实验(6MWT) [MD = 57.86, 95%CI (37.98, 77.74), Z = 5.71, P < 0.00001]、氨基末端B-型利钠肽(NT-proBNP) [MD = −153.78, 95%CI (−286.40, −21.15), Z = 2.27, P = 0.02]、明尼苏达心功能不全生命质量量表(MLHFQ) [MD = −7.02, 95%CI (−8.09, −5.96), Z = 12.94, P < 0.00001]，差异有统计学意义，异质性检验(I2 > 50%)。结论：当前证据表明，八段锦联合常规治疗在改善LVEF上明显优于常规治疗，在改善6 min步行试验、NT-proBNP及MLHFQ方面，八段锦联合常规治疗优于单纯常规治疗。

Abstract: Objective: To systematically evaluate the efficacy of Baduanjin combined with conventional treat-ment in patients with chronic heart failure. Method: Search Chinese databases such as China Bio-medical Literature Database (CBM), CNKI, and the English database: Cochrane Library, PubMed etc. of Baduanjin combined with conventional therapy to intervene randomized controlled trials (RCTs) in patients with chronic heart failure. The retrieval time was from the establishment of the data-base to December 2021. The quality of the articles was assessed using the Physical Therapy Evi-dence Database Scale (PEDro Scale). And RevMan5.3 software was used to carry out Meta analysis on the data. Results: A total of 15 Chinese literatures were finally included. Meta-analysis results showed that the LVEF of Baduanjin exercise [MD = 2.40, 95%CI (1.52, 3.28), Z = 5.35, P < 0.00001], the difference was statistically significant, and the heterogeneity test (P = 0.10, I2 = 41%). Among them, 6MWT [MD = 57.86, 95%CI (37.98, 77.74), Z = 5.71, P < 0.00001], NT-proBNP [MD = −153.78, 95%CI (−286.40, −21.15), Z = 2.27, P = 0.02], MLHFQ [MD = −7.02, 95%CI (−8.09, −5.96), Z = 12.94, P < 0.00001], the difference was statistically significant, but the heterogeneity test was all obvious (I2 > 50%). Conclusion: Current evidence shows that Baduanjin combined with conventional therapy is significantly better than conventional therapy in improving LVEF, and in improving 6-min walk test, NT-proBNP and MLHFQ, Baduanjin combined with conventional therapy is superior to conven-tional therapy alone.