脂联素在结直肠息肉及结直肠癌中的作用研究

Effect of Adiponectin on Colorectal Polyps and Colorectal Cancer

摘要: 肥胖相关的代谢紊乱与结直肠癌(colorectal cancer, CRC)的发展之间存在既定的联系。结直肠腺瘤是结直肠癌的癌前病变，属于大肠良性上皮肿瘤。结直肠癌的发展受多种因素影响，包括遗传、肠道微生物群、肠道炎症/感染、代谢疾病、转移部位的微环境和环境因素。有研究显示，低脂联素水平或是结直肠癌的危险因素。大量研究报告，脂联素水平低与CRC的不良结局有关，脂联素可能是CRC启动和发展的关键参与者。评估结直肠息肉和结直肠癌患者的血清脂联素水平，探索血清脂联素水平是否可以作为结直肠癌的预测因子/指标很重要，尤其是在结直肠癌的早期阶段，了解这些机制将有助于开发新的生物标志物和治疗策略来对抗CRC。因此本文综述了脂联素可作为临床上结直肠癌患者病情进展的一项生物指标，为临床上治疗结直肠癌的药物治疗和靶向治疗提供新的思路和理论基础。

Abstract: There is an established link between obesity-related metabolic disorders and the development of colorectal cancer (CRC). Colorectal adenoma is a precancerous lesion of colorectal cancer and is a benign epithelial tumor of the large intestine. The development of colorectal cancer is affected by many factors, including heredity, intestinal microbiome, intestinal inflammation/infection, meta-bolic diseases, microenvironmental and environmental factors at the metastatic site. Studies have shown that low lipotin levels may be a risk factor for colorectal cancer. A large number of studies have reported that low levels of adipoline are related to the adverse outcomes of CRC, which may be a key player in the start-up and development of CRC. It is important to evaluate the serum adip-tonin levels of patients with colorectal polyps and colorectal cancer, and explore whether serum aditin levels can be used as predictors/indicators for colorectal cancer, especially in the early stages of colorectal cancer. Understanding these mechanisms will help develop new biomarkers and treatment strategies to fight CRC. Therefore, this article reviews that adicotin can be used as a bio-logical indicator of the progress of patients with clinical colorectal cancer, providing new ideas and theoretical basis for drug treatment and targeted treatment of clinical colorectal cancer.