生物标志物在诊断和筛查肌肉减少症中的应用前景
Application Prospects of Biomarkers in the Diagnosis and Screening of Sarcopenia
DOI: 10.12677/ACM.2023.1381818, PDF,   
作者: 李洪安：青海大学临床医学院，青海 西宁；王 叶*：青海省人民医院内分泌科，青海 西宁
关键词: 肌肉减少症；诊断；筛查工具；生物标志物；Sarcopenia； Diagnosis； Screening Tools； Biomarkers
摘要: 肌肉减少症(简称肌少症)是一种衰老相关的疾病，表现为年龄相关的骨骼肌质量和功能的衰退。肌少症缺乏特异的临床表现，轻症较难发现，一旦出现衰弱、跌倒等不良事件，通常伴随着显著的肌肉质量下降及功能减退。因此选择简单有效的工具，早期识别肌少症进行干预，有利于延缓疾病的发生和发展，维护患者生活质量。本文通过总结相关国内外文献，对肌少症的现有诊断标准及筛查工具进行分析和比较，重点探讨目前诊筛工具的优势与不足，并对肌少症生物标志物进行分析总结，以期为肌少症筛查工具的选择及准确评估提供思考。生物标志物以其独有的特点，在肌少症的筛查和诊断中可能具有潜在价值。
Abstract: Sarcopenia is an age-related disease characterized by age-related decline in skeletal muscle mass and function. Sarcopenia lacks specific clinical manifestations and is difficult to detect in mild cases. Once adverse events such as weakness and falls occur, it is usually accompanied by significant loss of muscle mass and function. Therefore, the selection of simple and effective tools and early identi-fication of sarcopenia for intervention are conducive to delaying the occurrence and development of the disease and maintaining the quality of life of patients. This article summarizes the relevant do-mestic and foreign literature, analyzes and compares the existing diagnostic criteria and screening tools for sarcopenia, focuses on the advantages and disadvantages of the current diagnostic and screening tools, and analyzes and summarizes the biomarkers of sarcopenia, in order to provide thinking for the selection and accurate evaluation of screening tools for sarcopenia. With their unique characteristics, biomarkers may have potential value in the screening and diagnosis of sar-copenia.
文章引用：李洪安, 王叶. 生物标志物在诊断和筛查肌肉减少症中的应用前景[J]. 临床医学进展, 2023, 13(8): 12982-12989. https://doi.org/10.12677/ACM.2023.1381818

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