脓毒症心肌病诊断方法的研究新进展
New Progress in Research on Diagnostic Methods for Sepsis Cardiomyopathy
DOI: 10.12677/ACM.2023.1381819, PDF,   
作者: 潘志威, 杨连成, 杨立新*：新疆医科大学附属肿瘤医院重症医学科，新疆 乌鲁木齐
关键词: 脓毒症；脓毒症心肌病；诊断；Sepsis； Sepsis Cardiomyopathy； Diagnosis
摘要: 脓毒症的概念近年来有了新的进展，脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍，是重症监护病房中死亡的主要原因。脓毒症引起的心功能障碍，通常被称为脓毒症所致的心肌病，是一种常见的疾病，长期以来一直是人们感兴趣的主题。但脓毒症心肌病的定义目前尚未明确，故对于脓毒症心肌病的诊断有着很大的挑战。随着诊断技术的进步，提高了检测心肌异常的敏感性。本文通过回顾既往文献，总结了脓毒症心肌病诊断的方法，为临床应用提供参考。
Abstract: The concept of sepsis has made new progress in recent years. Sepsis is a life-threatening organ dys-function caused by the host’s maladjusted response to infection, and is the main cause of death in ICU. The cardiac dysfunction caused by sepsis, usually referred to as cardiomyopathy caused by sepsis, is a common disease and has long been a subject of interest. However, the definition of sepsis cardiomyopathy has not yet been clarified, so there is a great challenge for the diagnosis of sepsis cardiomyopathy. With the development of diagnostic techniques, the sensitivity of detecting myo-cardial abnormalities has been improved. This article reviewed the previous literature, summa-rized the diagnosis methods of sepsis cardiomyopathy, and provided reference for clinical applica-tion.
文章引用：潘志威, 杨连成, 杨立新. 脓毒症心肌病诊断方法的研究新进展[J]. 临床医学进展, 2023, 13(8): 12990-12995. https://doi.org/10.12677/ACM.2023.1381819

参考文献

[1] Evans, L., Rhodes, A., Alhazzani, W., et al. (2021) Surviving Sepsis Campaign: International Guidelines for Manage-ment of Sepsis and Septic Shock 2021. Critical Care Medicine, 49, e1063-e1143.
[2] Fleischmann, C., Scherag, A., Adhikari, N.K., et al. (2016) Assessment of Global Incidence and Mortality of Hospital-Treated Sepsis. Current Esti-mates and Limitations. American Journal of Respiratory and Critical Care Medicine, 193, 259-272. [Google Scholar] [CrossRef] 
[3] 中国医疗保健国际交流促进会急诊医学分会, 中华医学会急诊医学分会,中国医师协会急诊医师分会, 中国人民解放军急救医学专业委员会. 中国“脓毒症早期预防与阻断”急诊专家共识[J]. 中华危重病急救医学, 2020, 32(5): 518-530.
[4] Ehrman, R.R., Sullivan, A.N., Favot, M.J., et al. (2018) Pathophysiology, Echocardiographic Evaluation, Biomarker Findings, and Prognostic Implications of Septic Cardiomyopathy: A Review of the Literature. Critical Care, 22, Article No. 112. [Google Scholar] [CrossRef] [PubMed]
[5] Beesley, S.J., Weber, G., Sarge, T., et al. (2018) Septic Cardio-myopathy. Critical Care Medicine, 46, 625-634. [Google Scholar] [CrossRef] 
[6] Martin, L., Derwall, M., Al Zoubi, S., et al. (2019) The Septic Heart: Current Understanding of Molecular Mechanisms and Clinical Implications. Chest, 155, 427-437. [Google Scholar] [CrossRef] [PubMed]
[7] Custodero, C., Wu, Q., Ghita, G.L., et al. (2019) Prognostic Value of NT-proBNP Levels in the Acute Phase of Sepsis on Lower Long-Term Physical Function and Muscle Strength in Sepsis Survivors. Critical Care, 23, Article No. 230. [Google Scholar] [CrossRef] [PubMed]
[8] Hollenberg, S.M. and Singer, M. (2021) Pathophysiology of Sep-sis-Induced Cardiomyopathy. Nature Reviews Cardiology, 18, 424-434. [Google Scholar] [CrossRef] [PubMed]
[9] Carbone, F., Liberale, L., Preda, A., Schindler, T. H. and Mon-tecucco, F. (2022) Septic Cardiomyopathy: From Pathophysiology to the Clinical Setting. Cells, 11, Article No. 2833. [Google Scholar] [CrossRef] [PubMed]
[10] El-Battrawy, I., Lang, S., Ansari, U., et al. (2018) Prevalence of Ma-lignant Arrhythmia and Sudden Cardiac Death in Takotsubo Syndrome and Its Management. EP Europace, 20, 843-850. [Google Scholar] [CrossRef] [PubMed]
[11] Lima, M.R. and Silva, D. (2023) Septic Cardiomyopathy: A Narra-tive Review. Revista Portuguesa de Cardiologia, 42, 471-481. [Google Scholar] [CrossRef] [PubMed]
[12] Sevilla Berrios, R.A., O’Horo, J.C., Velagapudi, V. and Pulido, J.N. (2014) Correlation of Left Ventricular Systolic Dysfunction Determined by Low Ejection Fraction and 30-Day Mortality in Patients with Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Journal of Critical Care, 29, 495-499. [Google Scholar] [CrossRef] [PubMed]
[13] Tullo, G., Candelli, M., Gasparrini, I., Micci, S. and Franceschi, F. (2023) Ultrasound in Sepsis and Septic Shock-From Diagnosis to Treatment. Journal of Clinical Medicine, 12, Article No. 1185. [Google Scholar] [CrossRef] [PubMed]
[14] Sanfilippo, F., Corredor, C., Fletcher, N., et al. (2018) Left Ventricular Systolic Function Evaluated by Strain Echocardiography and Relationship with Mortality in Patients with Se-vere Sepsis or Septic Shock: A Systematic Review and Meta-Analysis. Critical Care, 22, Article No. 183. [Google Scholar] [CrossRef] [PubMed]
[15] Wang, S., Chen, K., Wang, Y., et al. (2023) Cardiac-Targeted De-livery of Nuclear Receptor RORα via Ultrasound Targeted Microbubble Destruction Optimizes the Benefits of Regular Dose of Melatonin on Sepsis-Induced Cardiomyopathy. Biomaterials Research, 27, Article No. 41. [Google Scholar] [CrossRef] [PubMed]
[16] Sanfilippo, F., Corredor, C., Arcadipane, A., et al. (2017) Tissue Doppler Assessment of Diastolic Function and Relationship with Mortality in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis. British Journal of Anaesthesia, 119, 583-594. [Google Scholar] [CrossRef] [PubMed]
[17] Brown, S.M., Pittman, J.E., Hirshberg, E.L., et al. (2012) Diastolic Dys-function and Mortality in Early Severe Sepsis and Septic Shock: A Prospective, Observational Echocardiography Study. Critical Ultrasound Journal, 4, Article No. 8. [Google Scholar] [CrossRef] [PubMed]
[18] Hollenberg, S.M. (2011) Vasoactive Drugs in Circulatory Shock. American Journal of Respiratory and Critical Care Medicine, 183, 847-855. [Google Scholar] [CrossRef] 
[19] Damy, T., Ghio, S., Rigby, A.S., et al. (2013) Interplay between Right Ventricular Function and Cardiac Resynchronization Therapy. Journal of the American College of Cardiology, 61, 2153-2160. [Google Scholar] [CrossRef] [PubMed]
[20] Kim, J.-S., Kim, Y.-J., Kim, M., et al. (2020) Association between Right Ventricle Dysfunction and Poor Outcome in Patients with Septic Shock. Heart, 106, 1665-1671. [Google Scholar] [CrossRef] [PubMed]
[21] Lanspa, M.J., Cirulis, M.M., Wiley, B.M., et al. (2021) Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest, 159, 1055-1063. [Google Scholar] [CrossRef] [PubMed]
[22] (2016) Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of, Cardiovascular Imaging. European Heart Journal-Cardiovascular Imaging, 17, 412. [Google Scholar] [CrossRef] [PubMed]
[23] Gajanana, D., Seetha Rammohan, H., Alli, O., et al. (2015) Tricuspid Annular Plane Systolic Excursion and Its Association with Mortality in Critically Ill Patients. Echocardiography, 32, 1222-1227. [Google Scholar] [CrossRef] [PubMed]
[24] Orde, S.R., Pulido, J.N., Masaki, M., et al. (2014) Outcome Prediction in Sepsis: Speckle Tracking Echocardiography Based Assessment of Myocardial Function. Critical Care, 18, Article No. R149. [Google Scholar] [CrossRef] [PubMed]
[25] Thygesen, K., Alpert, J.S., Jaffe, A.S., et al. (2019) Fourth Universal Definition of Myocardial Infarction (2018). European Heart Journal, 40, 237-269. [Google Scholar] [CrossRef] [PubMed]
[26] Landesberg, G., Jaffe, A.S., Gilon, D., et al. (2014) Troponin Eleva-tion in Severe Sepsis and Septic Shock: The Role of Left Ventricular Diastolic Dysfunction and Right Ventricular Dilata-tion. Critical Care Medicine, 42, 790-800. [Google Scholar] [CrossRef] 
[27] Oremek, G.M., Passek, K., Holzgreve, F., von der Eltz, V. and Dröge, J. (2023) [The Biomarkers BNP and NT-proBNP]. Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Er-gonomie, 73, 89-95. [Google Scholar] [CrossRef] [PubMed]
[28] Sahay, B., Bashant, K., Nelson, N.L.J., et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infection and Immunity, 86, e00781-17. [Google Scholar] [CrossRef] 
[29] Induruwa, I., Hennebry, E., Hennebry, J., et al. (2022) Sepsis-Driven Atrial Fibrillation and Ischaemic Stroke. Is There Enough Evidence to Recommend Anticoagulation? European Journal of Internal Medicine, 98, 32-36. [Google Scholar] [CrossRef] [PubMed]
[30] York, M.K., Gupta, D.K., Reynolds, C.F., et al. (2018) B-Type Natriuretic Peptide Levels and Mortality in Patients with and without Heart Failure. Journal of the American College of Cardiology, 71, 2079-2088. [Google Scholar] [CrossRef] [PubMed]
[31] Moskalets, O.V. (2018) Diagnostic and Prognostic Value of As-sessment of Soluble Adhesion Molecules sICAM-1 and sVCAM-1 in Septic Patients. Kazanskiĭ Meditsinskiĭ Zhurnal, 99, 645-650. [Google Scholar] [CrossRef] 
[32] L’Heureux, M., Sternberg, M., Brath, L., Turlington, J. and Kashiouris, M.G. (2020) Sepsis-Induced Cardiomyopathy: A Comprehensive Review. Current Cardiology Reports, 22, Article No. 35. [Google Scholar] [CrossRef] [PubMed]
[33] Werdan, K., Oelke, A., Hettwer, S., et al. (2011) Septic Cardio-myopathy: Hemodynamic Quantification, Occurrence, and Prognostic Implications. Clinical Research in Cardiology, 100, 661-668. [Google Scholar] [CrossRef] [PubMed]
[34] Wilhelm, J., Hettwer, S., Schuermann, M., et al. (2013) Severity of Cardiac Impairment in the Early Stage of Community-Acquired Sepsis Determines Worse Prognosis. Clinical Re-search in Cardiology, 102, 735-744. [Google Scholar] [CrossRef] [PubMed]
[35] Muehlberg, F., Blaszczyk, E., Will, K., et al. (2022) Characteriza-tion of Critically Ill Patients with Septic Shock and Sepsis-Associated Cardiomyopathy Using Cardiovascular MRI. ESC Heart Failure, 9, 2147-2156. [Google Scholar] [CrossRef] [PubMed]

为你推荐