白头翁皂苷在癌症中的临床药理研究进展
Research Progress in Clinical Pharmacology of Pulsatilla saponins in Cancer
DOI: 10.12677/ACM.2023.1381830, PDF,   
作者: 王 钦*：湖北科技学院药学院，湖北 咸宁；张宇轩*, 段 娜#：西安交通大学第一附属医院，陕西 西安
关键词: 白头翁皂苷；癌症；临床药理；Pulsatilla saponins； Cancer； Clinical Pharmacology
摘要: 白头翁皂苷是从白头翁根茎中分离出的一种皂苷，其主要活性物质是单体白头翁皂苷B4，含量丰富，价格低廉，在临床上广泛应用，具有抗肿瘤、抗炎、抗病毒、肾损伤保护、镇痛、免疫调节等药理作用。在各种癌症类型中均具有抗癌活性。可以通过调节癌症相关的代谢信号通路来抑制癌症的发展。本文对白头翁皂苷B4临床药理作用的研究进展作一综述，以期为其开发利用提供参考。
Abstract: Pulsatilla saponin is a kind of saponin separated from the rhizome of Pulsatilla chinensis. Its main active substance is monomer Pulsatilla saponin B4, which is rich in content and cheap in price. It is widely used in clinical practice and has pharmacological effects such as anti-tumor, anti-inflam- matory, anti-virus, renal injury protection, analgesia, immune regulation, etc. It has anti-cancer ac-tivity in various cancer types. It can inhibit the development of cancer by regulating cancer related metabolic signaling pathways. In this paper, the research progress on the clinical pharmacological effects of Pulsatilla saponin B4 was reviewed, with a view to providing reference for its development and utilization.
文章引用：王钦, 张宇轩, 段娜. 白头翁皂苷在癌症中的临床药理研究进展[J]. 临床医学进展, 2023, 13(8): 13067-13073. https://doi.org/10.12677/ACM.2023.1381830

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