基于肠道菌群探讨从脾胃论治失眠
Discussion on the Treatment of Insomnia from Spleen and Stomach Based on Gut Microbiota
DOI: 10.12677/ACM.2023.1381834, PDF,   
作者: 何师哲：湖北中医药大学第一临床学院，湖北 武汉
关键词: 肠道菌群；脾胃；失眠；Gut Microbiota； Spleen and Stomach； Insomnia
摘要: 失眠是临床常见的病症，肠道菌群通过肠–脑轴作用于大脑，影响睡眠质量。肠道内的菌群可调节其神经递质的分泌功能，通过影响神经递质分泌，影响大脑的功能，导致失眠；而睡眠障碍影响肠道菌群的昼夜节律，破坏其稳态，从而改变肠道菌群的结构与丰度。中医“脾胃学说”与肠道菌群有许多相通之处，临床上采用益气健脾、清利胃肠湿热类治法不仅能调节肠道菌群，治疗失眠也取得了很好的疗效。为从脾胃论治失眠的机理研究提供有效的理论依据。
Abstract: Insomnia is a common clinical disease. The gut microbiota acts on the brain through the gut-brain- axis and affects the sleep quality. The gut microbiota can regulate the secretion function of its neu-rotransmitters, and influence the brain function by affecting the secretion of neurotransmitters, leading to insomnia. However, sleep disorders affect the circadian rhythm of gut microbiota, and destroy its steady state, thus change the structure and abundance of gut microbiota. There are many similarities between the theory of spleen and stomach of traditional Chinese medicine and the gut microbiota. In clinic, the treatment of invigorating Qi and spleen and clearing away the dampness and heat of stomach and intestine can not only regulate the gut microbiota, but also has a beneficial effect on insomnia. Thus, it provides an effective theoretical basis for the study of the mechanism of treating insomnia from spleen and stomach.
文章引用：何师哲. 基于肠道菌群探讨从脾胃论治失眠[J]. 临床医学进展, 2023, 13(8): 13097-13102. https://doi.org/10.12677/ACM.2023.1381834

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