TRPV1在消化系统恶性肿瘤中的研究进展
Research Progress of TRPV1 in Malignant Tumors of the Digestive System
DOI: 10.12677/ACM.2023.1381841, PDF,   
作者: 李文登*, 公佩涛, 翟 珂, 梁辰龙, 邵 山, 宋亚鲁#：济宁市兖州区人民医院肝胆胃肠血管外科，山东 济宁；郑 杰*：济宁市兖州区人民医院创伤骨科与小儿骨科，山东 济宁
关键词: TRPV1；消化系统；恶性肿瘤；TRPV1； Digestive System； Malignant Tumors
摘要: 瞬时受体电位香草醛亚家族1 (Transient receptor potential vanilloid subfamily member 1, TRPV1)，又称辣椒素受体(Vanilloid receptor, VR1)，是一类非选择性阳离子通道。近年来研究发现TRPV1具有多种生物学功能，与消化系统恶性肿瘤的发生发展密切相关，TRPV1有望成为判断肿瘤预后的新型生物学标志物及治疗的新靶点。本文就TRPV1在消化系统恶性肿瘤中的研究进展作一综述，旨在为肿瘤的诊断和治疗提供新思路。
Abstract: Transient receptor potential vanilloid subfamily member 1 (TRPV1), also known as capsaicin re-ceptor (VR1), is a class of non-selective cation channels. In recent years, TRPV1 has been found to have a variety of biological functions, which are closely related to the occurrence and development of malignant tumors of the digestive system, and TRPV1 is expected to become a new biological marker and new target for judging tumor prognosis. This article reviews the research progress of TRPV1 in malignant tumors of the digestive system, aiming to provide new ideas for the diagnosis and treatment of tumors.
文章引用：李文登, 郑杰, 公佩涛, 翟珂, 梁辰龙, 邵山, 宋亚鲁. TRPV1在消化系统恶性肿瘤中的研究进展[J]. 临床医学进展, 2023, 13(8): 13179-13185. https://doi.org/10.12677/ACM.2023.1381841

参考文献

[1] Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. (1997) The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway. Nature, 389, 816-824. [Google Scholar] [CrossRef] [PubMed]
[2] Cheng, Y. (2021) TRPV1 and Pie-zo: The 2021 Nobel Prize in Physiology or Medicine. IUCrJ, 9, 4-5. [Google Scholar] [CrossRef] 
[3] Yang, F. and Zheng, J. (2017) Understand Spiciness: Mecha-nism of TRPV1 Channel Activation by Capsaicin. Protein Cell, 8, 169-177. [Google Scholar] [CrossRef] [PubMed]
[4] 刘夏阳, 李壮, 周欣悦, 等. TRPV1的生物学功能研究进展[J]. 生物化学与生物物理进展, 2022: 1-14.
[5] Hurtado-Zavala, J.I., Ramachandran, B., Ahmed, S., et al. (2017) TRPV1 Regulates Excitatory Innervation of OLM Neurons in the Hippocampus. Nature Communications, 8, Article No. 15878. [Google Scholar] [CrossRef] [PubMed]
[6] Llovet, J.M., Kelley, R.K., Villanueva, A., et al. (2021) Hepatocellular Carcinoma. Nature Reviews Disease Primers, 7, 6. [Google Scholar] [CrossRef] [PubMed]
[7] Rychkov, G.Y. and Barritt, G.J. (2011) Expression and Function of TRP Channels in Liver Cells. Advances in Experimental Medi-cine and Biology, 704, 667-686. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, M., Liu, X., Liu, S., et al. (2020) Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer. Frontiers in Oncology, 10, Article No. 847. [Google Scholar] [CrossRef] [PubMed]
[9] Miao, X., Liu, G., Xu, X., et al. (2008) High Ex-pression of Vanilloid Receptor-1 Is Associated with Better Prognosis of Patients with Hepatocellular Carcinoma. Cancer Genetics and Cytogenetics, 186, 25-32. [Google Scholar] [CrossRef] [PubMed]
[10] Waning, J., Vriens, J., Owsianik, G., et al. (2007) A Novel Function of Capsaicin-Sensitive TRPV1 Channels: Involvement in Cell Migration. Cell Calcium, 42, 17-25. [Google Scholar] [CrossRef] [PubMed]
[11] Vriens, J., Janssens, A., Prenen, J., et al. (2004) TRPV Channels and Modulation by Hepatocyte Growth Factor/Scatter Factor in Human Hepatoblastoma (HepG2) Cells. Cell Calcium, 36, 19-28. [Google Scholar] [CrossRef] [PubMed]
[12] 韩璐, 狄翠霞, 毛爱红, 等. Capsazepine诱导人肝癌HepG2细胞凋亡机制研究[J]. 中华肿瘤防治杂志, 2015, 22(10): 764-769.
[13] Xie, C., Liu, G., Li, M., et al. (2019) Targeting TRPV1 on Cellular Plasticity Regulated by Ovol2 and Zeb1 in Hepatocellular Carcinoma. Biomedicine & Pharmacotherapy, 118, Article ID: 109270. [Google Scholar] [CrossRef] [PubMed]
[14] Nieto, M.A., Huang, R.Y., Jackson, R.A., et al. (2016) EMT: 2016. Cell, 166, 21-45. [Google Scholar] [CrossRef] [PubMed]
[15] Yang, X., Jiang, Z., Li, Y., et al. (2022) Non-Coding RNAs Regu-lating Epithelial-Mesenchymal Transition: Research Progress in Liver Disease. Biomedicine & Pharmacotherapy, 150, Article ID: 112972. [Google Scholar] [CrossRef] [PubMed]
[16] Chen, W.T., Lin, G.B., Lin, S.H., et al. (2018) Static Magnetic Field Enhances the Anticancer Efficacy of Capsaicin on HepG2 Cells via Capsaicin Receptor TRPV1. PLOS ONE, 13, e0191078. [Google Scholar] [CrossRef] [PubMed]
[17] 曹毛毛, 李贺, 孙殿钦, 等. 2000-2019年中国胃癌流行病学趋势分析[J]. 中华消化外科杂志, 2021, 20(1): 102-109.
[18] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[19] 邓蕊, 余苏云, 成鹏, 等. 基于TRPV1探讨辣椒素促进胃癌转移机制[J]. 中国药理学与毒理学杂志, 2021, 35(10): 741-742.
[20] Liu, L., Sun, X., Guo, Y., et al. (2022) Evodiamine In-duces ROS-Dependent Cytotoxicity in Human Gastric Cancer Cells via TRPV1/Ca2+ Pathway. Chemico-Biological In-teractions, 351, Article ID: 109756. [Google Scholar] [CrossRef] [PubMed]
[21] Gao, N., Yang, F., Chen, S., et al. (2020) The Role of TRPV1 Ion Channels in the Suppression of Gastric Cancer Development. Journal of Experimental & Clinical Cancer Research, 39, Article No. 206. [Google Scholar] [CrossRef] [PubMed]
[22] Yu, H., Jin, H., Gong, W., et al. (2013) Pharmacological Actions of Multi-Target-Directed Evodiamine. Molecules, 18, 1826-1843. [Google Scholar] [CrossRef] [PubMed]
[23] Zheng, R., Zhang, S., Zeng, H., et al. (2022) Cancer Incidence and Mortality in China, 2016. Journal of the National Cancer Center, 2, 1-9. [Google Scholar] [CrossRef] [PubMed]
[24] Vinuesa, A.G., Sancho, R., García-Limones, C., et al. (2012) Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer. Cancer Re-search, 72, 1705-1716. [Google Scholar] [CrossRef] 
[25] 付俊文, 何雪铼, 侯能易, 等. 瞬时受体电位香草酸亚型1在结肠癌组织中的表达及其对结肠癌细胞生物学行为的影响[J]. 实用医院临床杂志, 2019, 16(2): 156-159.
[26] 黄贤威, 李戈, 姚梦玮, 等. 辣椒碱通过TRPV1诱导结肠癌SW480细胞凋亡[J]. 中国实验方剂学杂志, 2021, 27(17): 75-82.
[27] Sung, B, Prasad, S., Ravindran, J., et al. (2012) Capsazepine, a TRPV1 Antagonist, Sensitizes Colorectal Cancer Cells to Apoptosis by TRAIL through ROS-JNK-CHOP-Mediated Upregulation of Death Receptors. Free Radical Biology and Medicine, 53, 1977-1987. [Google Scholar] [CrossRef] [PubMed]
[28] Hou, N., He, X., Yang, Y., et al. (2019) TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway. BioMed Research In-ternational, 2019, Article ID: 6712536. [Google Scholar] [CrossRef] [PubMed]
[29] de Jong, P.R., Takahashi, N., Harris, A.R., et al. (2014) Ion Channel TRPV1-Dependent Activation of PTP1B Suppresses EGFR-Associated Intestinal Tumorigenesis. Journal of Clinical Investigation, 124, 3793-3806. [Google Scholar] [CrossRef] 
[30] Faris, P., Ferulli, F., Vismara, M., et al. (2020) Hydrogen Sulfide-Evoked Intracellular Ca2+ Signals in Primary Cultures of Metastatic Colorectal Cancer Cells. Cancers (Basel), 12, Article No. 3338. [Google Scholar] [CrossRef] [PubMed]
[31] Aviello, G., Romano, B., Borrelli, F., et al. (2012) Chemopreventive Effect of the Non-Psychotropic Phytocannabinoid Cannabidiol on Experimental Colon Cancer. Journal of Molecular Medicine (Berlin), 90, 925-934. [Google Scholar] [CrossRef] [PubMed]
[32] Chen, Y., Li, J., Jin, L., et al. (2019) Fibulin-5 Contributes to Colorectal Cancer Cell Apoptosis via the ROS/MAPK and Akt Signal Pathways by Downregulating Transient Receptor Potential Cation Channel Subfamily V Member 1. Journal of Cellular Biochemistry, 120, 17838-17846. [Google Scholar] [CrossRef] [PubMed]
[33] Siegel, R.L., Miller, K.D. and Jemal, A. (2020) Cancer Statistics, 2020. CA: A Cancer Journal for Clinicians, 70, 7-30. [Google Scholar] [CrossRef] [PubMed]
[34] Mizrahi, J.D., Surana, R., Valle, J.W., et al. (2020) Pancreatic Cancer. The Lancet, 395, 2008-2020. [Google Scholar] [CrossRef] 
[35] Siegel, R.L., Miller, K.D., Fuchs, H.E., et al. (2021) Cancer Statistics, 2021. CA: A Cancer Journal for Clinicians, 71, 7-33. [Google Scholar] [CrossRef] [PubMed]
[36] Chen, X., Yi, B., Liu, Z., et al. (2020) Global, Regional and National Burden of Pancreatic Cancer, 1990 to 2017: Results from the Global Burden of Disease Study 2017. Pancreatology, 20, 462-469. [Google Scholar] [CrossRef] [PubMed]
[37] 徐超, 谭小平, 李杰, 等. 穿心莲内酯抑制胰腺癌SW1990细胞的作用机制[J]. 医学研究生学报, 2022, 35(7): 708-713.
[38] Hartel, M., di Mola, F.F., Selvaggi, F., et al. (2006) Vanilloids in Pancreatic Cancer: Potential for Chemotherapy and Pain Management. Gut, 55, 519-528. [Google Scholar] [CrossRef] [PubMed]
[39] Huang, J., Liu, J. and Qiu, L. (2020) Transient Receptor Potential Vanilloid 1 Promotes EGFR Ubiquitination and Modulates EGFR/MAPK Signalling in Pancreatic Cancer Cells. Cell Bi-ochemistry & Function, 38, 401-408. [Google Scholar] [CrossRef] [PubMed]
[40] Wu, M. and Zhang, P. (2020) EGFR-Mediated Autophagy in Tumourigene-sis and Therapeutic Resistance. Cancer Letters, 469, 207-216. [Google Scholar] [CrossRef] [PubMed]
[41] Levantini, E., Maroni, G., Del Re, M., et al. (2022) EGFR Sig-naling Pathway as Therapeutic Target in Human Cancers. Seminars in Cancer Biology.
[42] Nedaeinia, R., Avan, A., Manian, M., et al. (2014) EGFR as a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies. Current Drug Targets, 15, 1293-1301. [Google Scholar] [CrossRef] [PubMed]
[43] Morgan, E., Soerjomataram, I., Rumgay, H., et al. (2022) The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates from GLOBOCAN 2020. Gastroenterology, 163, 649-658.e2. [Google Scholar] [CrossRef] [PubMed]
[44] Huang, R., Wang, F., Yang, Y., et al. (2019) Recurrent Activa-tions of Transient Receptor Potential Vanilloid-1 and Vanilloid-4 Promote Cellular Proliferation and Migration in Esoph-ageal Squamous Cell Carcinoma Cells. FEBS Open Bio, 9, 206-225. [Google Scholar] [CrossRef] [PubMed]

为你推荐