支气管哮喘的非药物治疗：当前知识与未来视角
Non-Pharmacological Treatment of Bronchial Asthma: Current Knowledge and Future Perspectives
DOI: 10.12677/ACM.2023.1381844, PDF,   
作者: 韩 爽：青岛大学医学部，山东 青岛；张春玲*：青岛大学附属青岛市中心医院呼吸与危重症医学科，山东 青岛
关键词: 支气管哮喘；非药物治疗；Bronchial Asthma； Non-Drug Treatment Methods
摘要: 支气管哮喘是最常见的慢性炎症性气道疾病之一，呈反复发作的喘息、气急、胸闷及咳嗽，全世界有超过3.3亿人患有哮喘，每年导致全球约25万人死亡，全球疾病负担(GBD)研究显示，虽然一些国家的哮喘相关住院和死亡人数有所下降，但在过去30年中，全球因急性加重和日常症状而承受的负担增加了近20%。糖皮质激素是哮喘药物治疗的基石，尽管进行了有效的药物治疗，支气管哮喘仍继续损害大多数患者的生活质量。因此，非药物治疗如呼吸训练及支气管热成形术等治疗方法逐渐成为了支气管哮喘药物治疗的有效补充及部分替代。本文就支气管哮喘的非药物治疗方法做一综述。
Abstract: Bronchial asthma is one of the most common chronic inflammatory airway diseases, characterized by recurrent wheezing, dyspnea, chest tightness and coughing. More than 330 million people worldwide suffer from asthma, which causes about 250,000 deaths annually. The Global Burden of Disease (GBD) study shows that, although the number of asthma-related hospitalizations and deaths has declined in some countries, the burden of acute exacerbations and daily symptoms has increased by nearly 20% globally in the past 30 years. Glucocorticoids are the cornerstone of asth-ma drug therapy, but bronchial asthma continues to impair the quality of life of most patients de-spite effective drug treatment. Therefore, non-drug treatments such as breathing training and bronchial thermoplasty have gradually become effective supplements and partial alternatives to bronchial asthma drug therapy. This article reviews the non-drug treatment methods for bronchial asthma.
文章引用：韩爽, 张春玲. 支气管哮喘的非药物治疗：当前知识与未来视角[J]. 临床医学进展, 2023, 13(8): 13198-13206. https://doi.org/10.12677/ACM.2023.1381844

参考文献

[1] Reddel, H.K., Bacharier, L.B., Bateman, E.D., et al. (2022) Global Initiative for Asthma Strategy 2021: Executive Sum-mary and Rationale for Key Changes. European Respiratory Journal, 59, 14-35. [Google Scholar] [CrossRef] [PubMed]
[2] Pietinalho, A., Pelkonen, A. and Rytilä, P. (2009) Linkage between Smoking and Asthma. Allergy, 64, 1722-1727. [Google Scholar] [CrossRef] [PubMed]
[3] Boulet, L.P., Fitzgerald, J.M. and Reddel, H.K. (2015) The Revised 2014 GINA Strategy Report: Opportunities for Change. Current Opinion in Pulmonary Medicine, 21, 1-7. [Google Scholar] [CrossRef] 
[4] Henneberger, P.K., Patel, J.R., De Groene, G.J., et al. (2019) Workplace Interventions for Treatment of Occupational Asthma. Cochrane Database of Systematic Reviews, 10, CD006308. [Google Scholar] [CrossRef] 
[5] Szram, J. and Cullinan, P. (2013) Medical Surveillance for Prevention of Occupational Asthma. Current Opinion in Allergy and Clinical Immunology, 13, 138-144. [Google Scholar] [CrossRef] 
[6] Vagedes, J., Helmert, E., Kuderer, S., et al. (2021) The Buteyko Breathing Technique in Children with Asthma: A Randomized Controlled Pilot Study. Complementary Thera-pies in Medicine, 56, Article ID: 102582. [Google Scholar] [CrossRef] [PubMed]
[7] Coulson, E., Carpenter, L.M., Georgia, T.E., et al. (2022) Breath-ing Exercises in Older Adults with Asthma: A Blinded, Randomized, Placebo-Controlled Trial. Journal of Asthma, 59, 1438-1444. [Google Scholar] [CrossRef] [PubMed]
[8] Yang, Z.Y., Zhong, H.B., Mao, C., et al. (2016) Yoga for Asthma. Cochrane Database of Systematic Reviews, 4, CD010346.
[9] Das, R.R., Sankar, J. and Kabra, S.K. (2022) Role of Breathing Exercises in Asthma-Yoga and Pranayama. Indian Journal of Pediatrics, 89, 174-180. [Google Scholar] [CrossRef] [PubMed]
[10] Santino, T.A., Chaves, G.S., Freitas, D.A., Fregonezi, G.A.F. and Mendonça, K.M.P.P. (2020) Breathing Exercises for Adults with Asthma. Cochrane Database of Systematic Re-views, 3, CD001277. [Google Scholar] [CrossRef] 
[11] Duhamel, D.R. and Hales, J.B. (2010) Bronchial Thermo-plasty: A Novel Therapeutic Approach to Severe Asthma. Journal of Visualized Experiments, 45, e2428. [Google Scholar] [CrossRef] [PubMed]
[12] Nong, Y., Lin, J.T., Chen, X., et al. (2020) [Evaluation of the Effectiveness of Bronchial Thermoplasty in Patients with Severe Asthma in the Real World Two Years after Bronchial Thermoplasty Treatment]. National Medical Journal of China, 100, 1730-1735.
[13] Castro, M., Rubin, A.S., Laviolette, M., et al. (2010) Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Random-ized, Double-Blind, Sham-Controlled Clinical Trial. American Journal of Respiratory and Critical Care Medicine, 181, 116-124. [Google Scholar] [CrossRef] 
[14] Koshy, K., Sha, J., Bennetts, K. and Langton, D. (2021) Safety of Delivering Bronchial Thermoplasty in Two Treatment Sessions. Respiratory Research, 22, Article No. 307. [Google Scholar] [CrossRef] [PubMed]
[15] Facciolongo, N., Di Stefano, A., Pietrini, V., et al. (2018) Nerve Ablation after Bronchial Thermoplasty and Sustained Improvement in Severe Asthma. BMC Pulmonary Medicine, 18, Article No. 29. [Google Scholar] [CrossRef] [PubMed]
[16] Wen, C.Y., Liu, Y.F., Zhou, L., Zhang, H.X. and Tu, S.H. (2015) A Systematic and Narrative Review of Acupuncture Point Application Therapies in the Treatment of Allergic Rhinitis and Asthma during Dog Days. Evidence-Based Complementary and Alternative Medicine, 2015, Article ID: 846851. [Google Scholar] [CrossRef] [PubMed]
[17] Zhu, L., Zhang, W., Wong, V., et al. (2016) Randomized Trial of Acu-points Herbal Patching in Sanfu Days for Asthma in Clinical Remission Stage. Clinical and Translational Medicine, 5, e5. [Google Scholar] [CrossRef] [PubMed]
[18] Schend, J., Rowane, M., Sanan, N. and Hostoffer, S.R. (2020) An Osteopathic Modular Approach to Asthma: A Narrative Review. Journal of Osteopathic Medicine, 120, 774-782. [Google Scholar] [CrossRef] [PubMed]
[19] Field, T., Hernandez-Reif, M., Diego, M., et al. (2005) Cortisol De-creases and Serotonin and Dopamine Increase following Massage Therapy. International Journal of Neuroscience, 115, 1397-1413. [Google Scholar] [CrossRef] [PubMed]
[20] Jones, L.M., Regan, C., Wolf, K., et al. (2021) Effect of Osteo-pathic Manipulative Treatment on Pulmonary Function Testing in Children with Asthma. Journal of Osteopathic Medi-cine, 121, 589-596. [Google Scholar] [CrossRef] [PubMed]
[21] Yin, L.M., Wang, Y., Fan, L., et al. (2015) Efficacy of Acupuncture for Chronic Asthma: Study Protocol for a Randomized Controlled Trial. Trials, 16, Article No. 424. [Google Scholar] [CrossRef] [PubMed]
[22] Li, M., Zhang, X., Bao, H.P., Li, C.L. and Zhang, P.T. (2017) Acupuncture for Asthma: Protocol for a Systematic Review. Medicine, 96, e7296. [Google Scholar] [CrossRef] 
[23] Zhang, X., Lai, Z., Qiu, R., et al. (2021) Positive Change in Asthma Control Using Therapeutic Patient Education in Severe Uncontrolled Asthma: A One-Year Prospective Study. Asthma Research and Practice, 7, Article No. 10. [Google Scholar] [CrossRef] [PubMed]
[24] Pastva, A., Estell, K., Schoeb, T.R., Atkinson, T.P. and Schwiebert, L.M. (2004) Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic Asthma. The Journal of Immunology, 172, 4520-4526. [Google Scholar] [CrossRef] [PubMed]
[25] Freitas, P.D., Silva, A.G., Ferreira, P.G., et al. (2018) Exercise Improves Physical Activity and Comorbidities in Obese Adults with Asthma. Medicine & Science in Sports & Exercise, 50, 1367-1376. [Google Scholar] [CrossRef] 
[26] Peters, U., Dixon, A.E. and Forno, E. (2018) Obesity and Asthma. Journal of Allergy and Clinical Immunology, 141, 1169-1179. [Google Scholar] [CrossRef] [PubMed]
[27] Mims, J.W. (2015) Asthma: Definitions and Pathophysiology. In-ternational Forum of Allergy & Rhinology, 5, S2-S6. [Google Scholar] [CrossRef] [PubMed]
[28] Azmeh, R., Greydanus, D.E., Agana, M.G., et al. (2020) Update in Pediatric Asthma: Selected Issues. Disease-a-Month, 66, Article ID: 100886. [Google Scholar] [CrossRef] [PubMed]
[29] Sharma, V. and Cowan, D.C. (2021) Obesity, Inflammation, and Severe Asthma: An Update. Current Allergy and Asthma Reports, 21, Article No. 46. [Google Scholar] [CrossRef] [PubMed]
[30] Leatherman, J. (2015) Mechanical Ventilation for Severe Asthma. Chest, 147, 1671-1680. [Google Scholar] [CrossRef] [PubMed]
[31] Demoule, A., Brochard, L., Dres, M., et al. (2020) How to Ventilate Obstructive and Asthmatic Patients. Intensive Care Medicine, 46, 2436-2449. [Google Scholar] [CrossRef] [PubMed]
[32] Oddo, M., Feihl, F., Schaller, M.D. and Perret, C. (2006) Man-agement of Mechanical Ventilation in Acute Severe Asthma: Practical Aspects. Intensive Care Medicine, 32, 501-510. [Google Scholar] [CrossRef] [PubMed]
[33] Cao, N., Peng, L.J. and Du, W. (2022) [Meta Analysis of Rock Salt Aerosol Therapy for Respiratory Tract Diseases]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 40, 751-756.
[34] Schuers, M., Chapron, A., Guihard, H., Bouchez, T. and Darmon, D. (2019) Impact of Non-Drug Therapies on Asthma Control: A Systematic Review of the Literature. European Journal of General Practice, 25, 65-76. [Google Scholar] [CrossRef] [PubMed]
[35] Van Lieshout, R.J. and Macqueen, G.M. (2012) Relations between Asthma and Psychological Distress: An Old Idea Revisited. Chemical Immunology and Allergy, 98, 1-13.
[36] Håkansson, K., Renzi-Lomholt, M., Backer, V. and Ulrik, C.S. (2022) High Use of Antidepressant Medica-tion in Both Mild-to-Modelate and Possible Severe Asthma—A Nationwide Cohort Study. Journal of Asthma and Al-lergy, 15, 13-23. [Google Scholar] [CrossRef] 
[37] Yorke, J., Fleming, S. and Shuldham, C. (2005) Psychological Inter-ventions for Children with Asthma. Cochrane Database of Systematic Reviews, 4, CD003272. [Google Scholar] [CrossRef] 
[38] Yorke, J., Fleming, S.L. and Shuldham, C.M. (2006) Psychological Interventions for Adults with Asthma. Cochrane Database of Systematic Reviews, 1, CD002982. [Google Scholar] [CrossRef] 
[39] Azeemi, S., Rafiq, H.M., Ismail, I., Kazmi, S.R. and Azeemi, A. (2019) The Mechanistic Basis of Chromotherapy: Current Knowledge and Future Perspectives. Complemen-tary Therapies in Medicine, 46, 217-222. [Google Scholar] [CrossRef] [PubMed]
[40] Wickenheisser, V.A., Zywot, E.M., Rabjohns, E.M., et al. (2019) Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease. Current Allergy and Asthma Reports, 19, Article No. 37. [Google Scholar] [CrossRef] [PubMed]
[41] Gruber, W., Eber, E., Malle-Scheid, D., et al. (2002) Laser Acu-puncture in Children and Adolescents with Exercise Induced Asthma. Thorax, 57, 222-225. [Google Scholar] [CrossRef] [PubMed]
[42] Wang, X.Y., Ma, W.J., Liu, C.S. and Li, Y.X. (2014) Effect of Low-Level Laser Therapy on Allergic Asthma in Rats. Lasers in Medical Science, 29, 1043-1050. [Google Scholar] [CrossRef] [PubMed]
[43] Dabbous, O.A., Soliman, M.M., Mohamed, N.H., et al. (2017) Evaluation of the Improvement Effect of Laser Acupuncture Biostimulation in Asthmatic Children by Exhaled Inflamma-tory Biomarker Level of Nitric Oxide. Lasers in Medical Science, 32, 53-59. [Google Scholar] [CrossRef] [PubMed]
[44] Moskvin, S.V. and Khadartsev, A.A. (2020) Methods of Effective Low-Level Laser Therapy in the Treatment of Patients with Bronchial Asthma (Literature Review). Biomedicine, 10, Ar-ticle 1. [Google Scholar] [CrossRef] [PubMed]
[45] Calabrese, E.J., Dhawan, G., Kapoor, R. and Kozumbo, W.J. (2019) Radiotherapy Treatment of Human inflammAtory Diseases and Conditions: Optimal Dose. Human & Experimental Tox-icology, 38, 888-898. [Google Scholar] [CrossRef] [PubMed]
[46] Chew, M.T., Daar, E., Khandaker, M.U., et al. (2021) Low Radi-ation Dose to Treat Pneumonia and Other Inflammations. The British Journal of Radiology, 94, Article ID: 20201265. [Google Scholar] [CrossRef] [PubMed]
[47] Calabrese, E.J. and Dhawan, G. (2013) How Radiotherapy Was Histor-ically Used to Treat Pneumonia: Could It Be Useful Today? Yale Journal of Biology and Medicine, 86, 555-570.
[48] Kern, P.M. and Keilholz, L. (2009) Radio-Immunological Mechanisms of Anti-Inflammatory Treatment: Is There a Way from the Past into the Future? Autoimmunity, 42, 337-339. [Google Scholar] [CrossRef] [PubMed]
[49] Arenas, M., Sabater, S., Hernández, V., et al. (2012) An-ti-Inflammatory Effects of Low-Dose Radiotherapy. Indications, Dose, and Radiobiological Mechanisms Involved. Strahlentherapie und Onkologie, 188, 975-981. [Google Scholar] [CrossRef] [PubMed]
[50] Salomaa, S., Bouffler, S.D., Atkinson, M.J., Cardis, E. and Hamada, N. (2020) Is There Any Supportive Evidence for Low Dose Radiotherapy for COVID-19 Pneumonia? Interna-tional Journal of Radiation Biology, 96, 1228-1235. [Google Scholar] [CrossRef] [PubMed]
[51] Venkatesulu, B.P., Lester, S., Hsieh, C.E., et al. (2021) Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls. JNCI Cancer Spectrum, 5, pkaa103. [Google Scholar] [CrossRef] [PubMed]
[52] Rühle, P.F., Wunderlich, R., Deloch, L., et al. (2017) Modulation of the Peripheral Immune System after Low-Dose Radon Spa Therapy: Detailed Longitudinal Immune Monitoring of Patients within the RAD-ON01 Study. Autoimmunity, 50, 133-140. [Google Scholar] [CrossRef] [PubMed]
[53] Kim, J.S., Son, Y., Bae, M.J., et al. (2015) Continuous Ex-posure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma. PLOS ONE, 10, e0143403. [Google Scholar] [CrossRef] [PubMed]
[54] Mazzone, S.B. and Undem, B.J. (2016) Vagal Afferent Innerva-tion of the Airways in Health and Disease. Physiological Reviews, 96, 975-1024. [Google Scholar] [CrossRef] [PubMed]
[55] Srikanthan, K., Kistemaker, L., Slebos, D.J., et al. (2022) Tar-geted Lung Denervation Modulates the Mucosal Epithelial Transcriptome in COPD. ERJ Open Research, 8, 00146-2022. [Google Scholar] [CrossRef] [PubMed]
[56] Slebos, D.J., Klooster, K., Koegelenberg, C.F., et al. (2015) Targeted Lung Denervation for Moderate to Severe COPD: A Pilot Study. Thorax, 70, 411-419. [Google Scholar] [CrossRef] [PubMed]
[57] Hummel, J.P., Mayse, M.L., Dimmer, S. and Johnson, P.J. (2019) Physiologic and Histopathologic Effects of Targeted Lung Denervation in an Animal Model. Journal of Applied Physiology, 126, 67-76. [Google Scholar] [CrossRef] [PubMed]
[58] Pison, C., Shah, P.L., Slebos, D.J., et al. (2021) Safety of Denervation following Targeted Lung Denervation Therapy for COPD: AIRFLOW-1 3-Year Outcomes. Respiratory Research, 22, Article No. 62. [Google Scholar] [CrossRef] [PubMed]
[59] Wang, K., Sun, J., Gao, W., et al. (2021) Feasibility, Effective-ness, and Safety of a Novel Cryo-Balloon Targeted Lung Denervation Technique in an Animal Model. Cryobiology, 93, 27-32. [Google Scholar] [CrossRef] [PubMed]
[60] Hartman, J.E., Srikanthan, K., Caneja, C., et al. (2022) Bronchoscopic Targeted Lung Denervation in Patients with Severe Asthma: Preliminary Findings. Respiration, 101, 184-189. [Google Scholar] [CrossRef] [PubMed]

为你推荐