维生素D缺乏与儿童过敏性疾病相关性研究进展
Research Progress on the Relationship between Vitamin D Deficiency and Allergic Diseases in Children
摘要: 目前维生素D缺乏已经成为全球普遍的健康问题,同时有关儿童过敏性疾病的报道也逐年增多,严重影响着儿童的身心健康。近年来研究发现维生素D水平与生命早期的免疫系统以及儿童过敏性疾病密切相关。本文综述了维生素D水平与儿童呼吸道过敏、食物过敏、皮肤过敏、过敏性结膜炎之间的相关性并对未来治疗儿童过敏性疾病做出展望。
Abstract: At present, vitamin D deficiency has become a common health problem in the world, and the re-ports of allergic diseases in children are increasing year by year, which seriously affects the physical and mental health of children. Recent studies have found that vitamin D levels are closely related to the immune system in early life and childhood allergic diseases. This article reviews the association between vitamin D levels and respiratory allergies, food allergies, skin allergies, and allergic con-junctivitis in children, and provides an outlook for the future treatment of childhood allergic dis-eases.
文章引用:周甲颖, 何东玲, 张娟利. 维生素D缺乏与儿童过敏性疾病相关性研究进展[J]. 临床医学进展, 2023, 13(8): 13260-13266. https://doi.org/10.12677/ACM.2023.1381853

参考文献

[1] Hu, Y.C., Chen, J., Wang, R., et al. (2017) Vitamin D Nutritional Status and Its Related Factors for Chinese Children and Adolescents in 2010-2012. Nutrients, 9, 1024-1024. [Google Scholar] [CrossRef] [PubMed]
[2] 修小莹, 崔玉霞, 黄玉瑛, 等. 4-12岁哮喘儿童维生素D水平与哮喘控制及肺功能的关系[J]. 中国当代儿科杂志, 2018, 20(6): 461-464.
[3] Li, W., Zhou, J., Liu, S., et al. (2021) The Correlation between Neonatal Vitamin D Levels and the Risk of Childhood Asthma Attacks. Translational Pediatrics, 10, 914-920. [Google Scholar] [CrossRef] [PubMed]
[4] Hibbs, A.M., Ross, K., Kerns, L.A., et al. (2018) Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm: The D-Wheeze Randomized Clinical Trial [Published Correction Appears in JAMA. 2018 Aug 14, 320(6): 605]. JAMA, 319, 2086-2094. [Google Scholar] [CrossRef] [PubMed]
[5] Mirzakhani, H., Carey, V.J., Zeiger, R., et al. (2019) Impact of Parental Asthma, Prenatal Maternal Asthma Control, and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3-Year-Old Children. Clinical & Experimental Allergy, 49, 419-429. [Google Scholar] [CrossRef] [PubMed]
[6] 鞠婧婧, 李亚南, 赵宇蕾, 等. 血浆维生素D水平与儿童哮喘的相关性及布地奈德、异丙托溴铵雾化吸入联合维生素D的治疗效果[J]. 实用心脑肺血管病杂志, 2019, 27(11): 93-97.
[7] Forno, E., Bacharier, L.B., Phipatanakul, W., et al. (2020) Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children with Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial. JAMA, 324, 752-760. [Google Scholar] [CrossRef] [PubMed]
[8] Saad, K., Abdelmoghny, A., Aboul-Khair, M.D., et al. (2020) Vitamin D Status in Egyptian Children with Allergic Rhinitis. Ear, Nose & Throat Journal, 99, 508-512. [Google Scholar] [CrossRef] [PubMed]
[9] 赵学玲, 郑昕, 徐化梅, 等. 过敏性鼻炎患儿血清25(OH)D、特异性IgE水平与VAS评分的相关性[J]. 检验医学, 2021, 36(6): 615-617.
[10] Haziroglu, O.Z., Ce-liksoy, M.H. and Topal, E. (2021) The Effect of Serum Vitamin D Level on Allergic Rhinitis Symptoms in Children. Pe-diatric Allergy, Immunology, and Pulmonology, 34, 132-140. [Google Scholar] [CrossRef] [PubMed]
[11] Jerzyńska, J., Stelmach, W., Rychlik, B., et al. (2018) Clinical and Immunological Effects of Vitamin D Supplementation during the Pollen Season in Children with Allergic Rhinitis. Ar-chives of Medical Science, 14, 122-131. [Google Scholar] [CrossRef] [PubMed]
[12] Chen, Y.S., Mirzakhani, H., Lu, M., et al. (2021) The Association of Prenatal Vitamin D Sufficiency with Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood. The Journal of Allergy and Clinical Immunology: In Practice, 9, 3788-3796.e3. [Google Scholar] [CrossRef] [PubMed]
[13] Darwin, A.H., Carroll, M.P., Galvis Noda, S.D., et al. (2021) Cal-cium and Vitamin D Intake in Allergic versus Non-Allergic Children and Corresponding Parental Attitudes towards Dairy Products. World Allergy Organization Journal, 14, Article ID: 100579. [Google Scholar] [CrossRef] [PubMed]
[14] Litonjua, A.A., Carey, V.J., Laranjo, N., et al. (2020) Six-Year Follow-Up of a Trial of Antenatal Vitamin D for Asthma Reduction. The New England Journal of Medicine, 382, 525-533. [Google Scholar] [CrossRef
[15] Matsui, T., Yamashita, H., Saneyasu, K.I., et al. (2018) Vitamin D Deficiency Exacerbates Sensitization and Allergic Diarrhea in a Murine Food Allergy Model. Allergology In-ternational, 67, 289-291. [Google Scholar] [CrossRef] [PubMed]
[16] Poole, A., Song, Y., Brown, H., et al. (2018) Cellular and Molecular Mechanisms of Vitamin D in Food Allergy. Journal of Cellular and Molecular Medicine, 22, 3270-3277. [Google Scholar] [CrossRef] [PubMed]
[17] Nowak, S., Wang, H., Schmidt, B., et al. (2021) Vitamin D and Iron Sta-tus in Children with Food Allergy. Annals of Allergy, Asthma & Immunology, 127, 57-63. [Google Scholar] [CrossRef] [PubMed]
[18] Allen, K.J., Koplin, J.J., Ponsonby, A.L., Gurrin, L.C., Wake, M., Vuillermin, P., et al. (2013) Vitamin D Insufficiency Is Associated with Challenge-Proven Food Allergy in Infants. Journal of Allergy and Clinical Immunology, 131, 1109-1116.e1-6. [Google Scholar] [CrossRef] [PubMed]
[19] Pereira, A.P.D.S., Mendonça, R.B., Fonseca, F.L.A., et al. (2022) Vitamin D Deficiency in Children and Adolescents with Food Allergy: Association with Number of Allergens, Sun Ex-posure and Nutritional Status. Allergologia et Immunopathologia (Madr), 50, 10-16. [Google Scholar] [CrossRef] [PubMed]
[20] 周刚, 彭哲, 莫运波, 等. 维生素D水平与牛奶蛋白过敏患儿的相关性研究[J]. 现代生物医学进展, 2020, 20(20): 3911-3914+3896.
[21] 胡艳, 李传应, 吴成. 辅助性维生素D联合游离氨基酸治疗牛奶蛋白过敏患儿的临床疗效[J]. 安徽医学, 2021, 42(2): 129-132.
[22] He, C., Xiao, G., Liu, S., et al. (2021) A Prospective Cohort Study of Cord Blood 25(OH)D3 and Food Allergies in 6-Month-Old Chinese In-fants. Asian Pacific Journal of Allergy and Immunology, 39, 258-265.
[23] Rosendahl, J., Pelkonen, A.S., Helve, O., et al. (2019) High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants. The Journal of Pediatrics, 209, 139-145.e1. [Google Scholar] [CrossRef] [PubMed]
[24] Shimizu, M., Kato, T., Adachi, Y., et al. (2022) Association between Maternal Vitamin D Intake and Infant Allergies: The Japan Environment and Children’s Study. Journal of Nutritional Science and Vitaminology (Tokyo), 68, 375-382. [Google Scholar] [CrossRef] [PubMed]
[25] Tran, M.M., Lefebvre, D.L., Dharma, C., et al. (2018) Predicting the Atopic March: Results from the Canadian Healthy Infant Longitudinal Development Study. Journal of Allergy and Clin-ical Immunology, 141, 601-607.e8.
[26] Dogru, M. (2018) Is Vitamin D Level Associated with the natural course of Atopic Dermatitis? Allergologia et Immunopathologia (Madr), 46, 546-551. [Google Scholar] [CrossRef] [PubMed]
[27] 张幸, 陈信, 吕曹华. 儿童特应性皮炎的严重程度与血清25-羟维生素D和总IgE的相关性[J]. 中国妇幼保健, 2022, 37(1): 81-83.
[28] Lee, Y.W., Choon, S.E. and Izham, S. (2019) Serum 25-Hydroxyvitamin D Deficiency in Malaysian Children with Severe Atopic Dermatitis. Medical Journal of Malaysia, 74, 259-265.
[29] 何素妮, 周晓红, 苏婵, 等. 妊娠晚期孕妇维生素D水平与婴儿特应性皮炎的相关性研究[J]. 中国妇幼保健, 2018, 33(9): 2045-2046.
[30] Mansour, N.O., Mohamed, A.A., Hussein, M., et al. (2020) The Impact of Vitamin D Supplementation as an Adjuvant Therapy on Clinical Outcomes in Patients with Severe Atopic Dermatitis: A Randomized Controlled Trial. Pharmacology Research & Perspectives, 8, e00679. [Google Scholar] [CrossRef] [PubMed]
[31] Raj, K.A.P., Handa, S., Narang, T., et al. (2022) Correlation of Serum Vita-min D Levels with Severity of Pediatric Atopic Dermatitis and the Impact of Vitamin D Supplementation on Treatment Outcomes. Journal of Dermatological Treatment, 33, 1397-1400. [Google Scholar] [CrossRef] [PubMed]
[32] Yang, L., Sato, M., Saito-Abe, M., et al. (2021) Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study. Nutrients, 13, Article No. 2761. [Google Scholar] [CrossRef] [PubMed]
[33] Eltablawy, N., Ashour, H., Rashed, L.A., et al. (2018) Vitamin D Protec-tion from Rat Diabetic Nephropathy Is Partly Mediated through Klotho Expression and Renin-Angiotensin Inhibition. Archives of Physiology and Biochemistry, 124, 461-467. [Google Scholar] [CrossRef] [PubMed]
[34] Zhu, L., Zhang, C., Xiang, R., et al. (2022) Correlations of Leukotriene B4 and 25-Hydroxyvitamin D3 Levels with Disease Severity in Children with Henoch-Schonlein Purpura. Clinical Laboratory, 68. [Google Scholar] [CrossRef
[35] 王华胜, 许超. 过敏性紫癜患儿白三烯B4和25-羟基维生素D3水平与疾病严重程度的相关性研究[J]. 中国中西医结合皮肤性病学杂志, 2021, 20(5): 437-442.
[36] 唐雨珊, 李喜莲, 柏金秀, 等. 血清维生素A和25(OH)D水平与儿童过敏性紫癜的相关性[J]. 河北医药, 2021, 43(16): 2467-2470.
[37] Fu, Q., Shi, M.F. and Chen, Y. (2021) Clinical Effect of Alfacalcidol in Children with Henoch-Schönlein Purpura: A Prospective Randomized Controlled Trial. Chinese Journal of Contemporary Pediatrics, 23, 797-801.
[38] 张向勇, 江德琴, 刘蓉, 等. 维生素D对小儿过敏性紫癜的疗效及对免疫机制的影响[J]. 药学服务与研究, 2019, 19(3): 192-195.
[39] Tromp, I.I.M., Franco, O.H., van den Hooven, E.H., et al. (2018) 25-Hydroxyvitamin D Concentrations, Asthma and Eczema in Childhood: The Generation R Study. Clinical Nutrition, 37, 169-176. [Google Scholar] [CrossRef] [PubMed]
[40] 王毅红, 孙晓峰, 赵红纪. 维生素D缺乏与儿童湿疹严重程度及丁酸氢化可的松治疗效果分析[J]. 中国中西医结合皮肤性病学杂志, 2021, 20(2): 189-191.
[41] El-Heis, S., D’Angelo, S., Curtis, E.M., et al. (2022) Maternal Antenatal Vitamin D Supplementation and Offspring Risk of Atopic Eczema in the First 4 Years of Life: Evidence from a Randomized Controlled Trial. British Journal of Dermatology, 187, 659-666. [Google Scholar] [CrossRef] [PubMed]
[42] Woon, F.C., Chin, Y.S., Ismail, I.H., et al. (2020) Maternal Vita-min D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study. Nutrients, 12, Article No. 2418. [Google Scholar] [CrossRef] [PubMed]
[43] Rueter, K., Jones, A.P., Siafarikas, A., et al. (2020) In “High-Risk” In-fants with Sufficient Vitamin D Status at Birth, Infant Vitamin D Supplementation Had No Effect on Allergy Outcomes: A Randomized Controlled Trial. Nutrients, 12, Article No. 1747. [Google Scholar] [CrossRef] [PubMed]
[44] Ghiglioni, D.G., Bruschi, G., Gandini, S., et al. (2019) Vitamin D Serum Levels in Children with Vernal Keratoconjunctivitis and Disease Control. International Journal of Immunopathology and Pharmacology, 33. [Google Scholar] [CrossRef] [PubMed]
[45] Bozkurt, B., Artac, H., Ozdemir, H., et al. (2018) Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. Ocular Immunology and Inflammation, 26, 435-439. [Google Scholar] [CrossRef] [PubMed]
[46] 王虹, 王冬兰, 吉雷, 等. 儿童过敏性结膜炎与血清维生素D3水平相关性研究[J]. 黑龙江医药科学, 2020, 43(6): 28-29.