坐骨神经痛的研究进展
Research Progress in Sciatica
DOI: 10.12677/ACM.2023.1381855, PDF,   
作者: 曲艳平*, 贺文廷, 王 旭, 董 浩:大理大学临床医学院,云南 大理;范智东#:大理大学第一附属医院麻醉科,云南 大理
关键词: 坐骨神经痛中医治疗银杏叶Sciatica Traditional Chinese Medicine Treatment Ginkgo Leaf
摘要: 坐骨神经痛是坐骨神经受损之后所产生的一种由坐骨神经s通路延伸至其所分布区域疼痛的临床综合症,多表现为剧烈性疼痛和隐匿性疼痛相结合,有的还可伴有下腰椎的隐隐疼痛,给患者带来极度的不适感,大大降低了生活质量,随着医学的发展及人们对生活质量要求的增高,由坐骨神经痛所影响的周围神经基因表达的脊髓疾病中神经性疼痛终生发生率高达40%,多发生在40~60岁人群,尽管坐骨神经痛的发病率很高,但能够完全治愈的却寥寥无几。近几年对坐骨神经痛的研究日益加深,本文对近年来坐骨神经痛在临床中的研究进行综述。
Abstract: Sciatic neuralgia is a clinical syndrome that occurs after sciatic nerve damage, extending from the sciatic nerve pathway to the area where it is distributed. It is often manifested as a combination of intense pain and hidden pain, and some may also be accompanied by hidden pain in the lower lumbar spine, causing extreme discomfort to patients and greatly reducing their quality of life. With the development of medicine and the increasing demand for quality of life, the lifetime incidence of neuropathic pain in spinal cord diseases affected by Sciatica and expressed by peripheral nerve genes is as high as 40%, mostly in people aged 40~60 years. Although the incidence rate of sciatica is very high, few can be completely cured. In recent years, the research on sciatica has been deep-ening day by day. This article reviews the clinical research on sciatica in recent years.
文章引用:曲艳平, 贺文廷, 王旭, 董浩, 范智东. 坐骨神经痛的研究进展[J]. 临床医学进展, 2023, 13(8): 13272-13279. https://doi.org/10.12677/ACM.2023.1381855

参考文献

[1] Ropper, A.H. and Zafonte, R.D. (2015) Sciatica. The New England Journal of Medicine, 372, 1240-1248. [Google Scholar] [CrossRef
[2] Jiang, C., Li, Y., Guo, M., Li, X., Guo, J., Yu, S. and Lin, Z. (2018) Acupotomy Therapy for Lumbar Disc Herniation: Protocol for a Systematic Review and Meta-Analysis. Medicine, 97, e12624. [Google Scholar] [CrossRef
[3] 崔艳红, 张赛, 陈旭义, 程明, 宋绪鹏, 刘洋. 坐骨神经痛的研究进展[J]. 中国医药, 2019, 14(7): 1114-1117.
[4] Stynes, S., Konstantinou, K., Ogollah, R., Hay, E.M. and Dunn, K.M. (2018) Clinical Diagnostic Model for Sciatica Developed in Primary Care Patients with Low Back-Related Leg Pain. PLOS ONE, 13, e0191852. [Google Scholar] [CrossRef] [PubMed]
[5] Konstantinou, K., Dunn, K.M., Ogollah, R., Lewis, M., van der Windt, D., Hay, E.M. and ATLAS Study Team (2018) Prognosis of Sciatica and Back-Related Leg Pain in Primary Care: The ATLAS Cohort. The Spine Journal, 18, 1030-1040. [Google Scholar] [CrossRef] [PubMed]
[6] Deville, W.L., van der Windt, D.A., Dzaferagic, A., Bezemer, P.D. and Bouter, L.M. (2000) The Test of Lasegue: Systematic Review of the Accuracy in Diagnosing Herniated Discs. Spine, 25, 1140-1147. [Google Scholar] [CrossRef] [PubMed]
[7] Singh, R., Yadav, S.K., Sood, S., Yadav, R. and Rohilla, R. (2018) Evaluation of the Correlation of Magnetic Resonance Imaging and Electrodiagnostic Findings in Chronic Low Backache Patients. Asian Journal of Neurosurgery, 13, 1078-1083. [Google Scholar] [CrossRef
[8] Lewis, R.A., Williams, N.H., Sutton, A.J., Burton, K., Din, N.U., Matar, H.E., Hendry, M., Phillips, C.J., Nafees, S., Fitzsimmons, D., Rickard, I. and Wilkinson, C. (2015) Comparative Clinical Effectiveness of Management Strategies for Sciatica: Systematic Review and Network Meta-Analyses. The Spine Journal, 15, 1461-1477. [Google Scholar] [CrossRef] [PubMed]
[9] 姜志钊, 李毅中. 腰椎间盘突出所致坐骨神经痛发病机制[J]. 国际骨科学杂志, 2010, 31(2): 102-104.
[10] Vij, N., Kiernan, H., Bisht, R., Singleton, I., Cornett, E.M., Kaye, A.D., Imani, F., Varrassi, G., Pourbahri, M., Viswanath, O. and Urits, I. (2021) Surgical and Non-Surgical Treatment Options for Piriformis Syndrome: A Literature Review. Anesthesiology and Pain Medicine, 11, e112825. [Google Scholar] [CrossRef] [PubMed]
[11] Hicks, B.L., Lam, J.C. and Varacallo, M. (2022) Piriformis Syndrome. StatPearls, Treasure Island.
[12] Fager, C.A. (1994) Observations on Spontaneous Recovery from Intervertebral Disc Herniation. Surgical Neurology, 42, 282-286. [Google Scholar] [CrossRef
[13] 尚希福, 戴尅戎, 朱六龙. 骶髂部肿瘤引起的坐骨神经痛(附29例分析) [J]. 中国矫形外科杂志, 2001, 8(1): 5-7.
[14] Karjalainen, U., Paananen, M., Okuloff, A., Taimela, S., Auvinen, J., Mannikko, M. and Karppinen, J. (2013) Role of Environmental Factors and History of Low Back Pain in Sciatica Symptoms among Finnish Adolescents. Spine, 38, 1105-1111. [Google Scholar] [CrossRef
[15] Hagen, K.B., Jamtvedt, G., Hilde, G. and Winnem, M.F. (2005) The Updated Cochrane Review of Bed Rest for Low Back Pain and Sciatica. Spine, 30, 542-546. [Google Scholar] [CrossRef] [PubMed]
[16] Shen, Y., Zhou, Q., Qiu, Z., Jia, Y. and Li, S. (2018) Acupotomy for Calcaneodynia: A Systematic Review Protocol. Medicine, 97, e0143. [Google Scholar] [CrossRef
[17] Jacobs, W.C., van Tulder, M., Arts, M., Rubinstein, S.M., van Middelkoop, M., Ostelo, R., Verhagen, A., Koes, B. and Peul, W.C. (2011) Surgery versus Conservative Manage-ment of Sciatica Due to a Lumbar Herniated Disc: A Systematic Review. European Spine Journal, 20, 513-522. [Google Scholar] [CrossRef] [PubMed]
[18] Rasmussen-Barr, E., Held, U., Grooten, W.J., Roelofs, P.D., Koes, B.W., van Tulder, M.W. and Wertli, M.M. (2016) Non-Steroidal Anti-Inflammatory Drugs for Sciatica. Cochrane Database of Systematic Reviews, 10, CD012382. [Google Scholar] [CrossRef
[19] 李绍军, 邓兰萍. 基于痹证自拟痹痛散热透皮技术治疗颈椎病腰椎间盘突出症镇痛效应[J]. 中国中医药现代远程教育, 2022, 20(1): 131-133.
[20] 沈琪幸, 许金海, 夏烨, 徐华, 叶洁, 莫文. 痹证方联合西药治疗老年腰椎间盘突出症的临床研究[J]. 老年医学与保健, 2021, 27(3): 637-639, 656.
[21] 李向欣. 针灸治疗腰椎间盘突出所致坐骨神经痛的临床疗效分析[J]. 临床医药文献电子杂志, 2020, 7(48): 33, 81. [Google Scholar] [CrossRef
[22] 贺前松. 火针治疗腰椎间盘突出坐骨神经痛的疗效及其作用机理[J]. 西南国防医药, 2019, 29(10): 1016-1018.
[23] 潘昊天, 李璟, 冯晨晨, 裴丽娟, 奚紫琦, 侯文光, 王珂. 燔针劫刺针法对椎间盘源性坐骨神经痛疗效的影响: 随机对照试验[J]. 中国针灸, 2022, 42(3): 261-266. [Google Scholar] [CrossRef] [PubMed]
[24] 周强, 冯喜莲, 李姝睿, 文新, 刘乃嘉, 王琼, 赵峰, 张静婧, 肖玉霞. 不同推拿手法对坐骨神经痛模型大鼠的镇痛作用及其镇痛机制研究[J]. 甘肃中医药大学学报, 2020, 37(6): 1-4. [Google Scholar] [CrossRef
[25] 王东强, 郭义, 管兴东. 单味中药及提取单体促进周围神经损伤恢复的实验研究进展[J]. 天津中医药, 2008, 25(1): 86-88.
[26] 杨慧萍, 高睿. 银杏药用成分及药理作用研究进展[J]. 动物医学进展, 2017, 38(8): 96-99. [Google Scholar] [CrossRef
[27] 康伟. 银杏叶化学成分及其药用研究[J]. 中国卫生产业, 2014(2): 194-195. [Google Scholar] [CrossRef
[28] 林浩东, 王欢, 陈德松, 李继峰, 顾玉东. 银杏酮酯促进大鼠坐骨神经再生的实验研究[J]. 复旦学报(医学版), 2006, 33(4): 467-469, 486.
[29] Yu, X., Chen, C., Ke, Q., Tang, H., Hou, J. and Fang, W. (2015) EGb761 Ameliorates Neuropathic Pain by Scavenging Reactive Oxygen Spe-cies. Pharmacology, 95, 293-299. [Google Scholar] [CrossRef] [PubMed]
[30] Basu, P. and Basu, A. (2020) In vitro and in vivo Effects of Flavonoids on Peripheral Neuropathic Pain. Molecules, 25, Article 1171. [Google Scholar] [CrossRef] [PubMed]
[31] 吕平, 林明涛. 银杏内酯对活性氧自由基和过氧化氢清除作用的研究[J]. 华北农学报, 2010, 25(1): 151-154.
[32] 李敏. 银杏叶总黄酮的提取及其抗氧化性的研究[J]. 应用化工, 2013, 42(6): 1023-1025, 1032. [Google Scholar] [CrossRef
[33] 邹锋, 陈军, 焦志华, 曹译匀, 钟文晖, 王爱忠. 磷酸化c-Jun氨基末端激酶在银杏叶提取物缓解神经病理性疼痛中的作用[J]. 国际麻醉学与复苏杂志, 2019, 40(10): 907-910.
[34] Dewan, S.A.M., 练桂丽, 叶鹏. 过氧亚硝基阴离子对肾功能的调节及其在盐敏感性高血压中的病理生理学意义[J]. 中华高血压杂志, 2017, 25(11): 1014-1018.
[35] 张烽, 顾玉东, 徐建光, 李继峰. 银杏叶提取物促进大鼠坐骨神经再生的实验研究[J]. 中华显微外科杂志, 2000, 23(4): 279.
[36] 黄建, 刘之荣. 银杏内酯B的神经保护作用及机制研究进展[J]. 国际神经病学神经外科学杂志, 2014, 41(6): 559-562. [Google Scholar] [CrossRef
[37] 马国平, 杨京利, 田玉科, 刘菊英. 鞘内注射银杏内酯B对神经病理痛大鼠痛阈及脊髓c-fos表达的影响[J]. 中国疼痛医学杂志, 2009, 15(3): 154-157.
[38] Zhao, R., Liu, W., Wang, M., Zhang, Y., Pan, L., Feng, F., Xia, T. and Yang, L. (2020) Lysyl Oxidase Inhibits TNF-α Induced Rat Nucleus Pulposus Cell Apoptosis via Regulating Fas/FasL Pathway and the p53 Pathways. Life Sciences, 260, Article ID: 118483. [Google Scholar] [CrossRef] [PubMed]
[39] 林玲辉. 银杏叶多糖的抗炎活性及其抗炎信号转导机制[D]: [硕士学位论文]. 长春: 吉林大学, 2012.