定量CT应用于糖尿病骨质疏松症的研究进展

Research Progress of Quantitative CT in Diabetic Osteoporosis

摘要: 随着糖尿病患病率的逐年增加，骨质疏松症(osteoporosis, OP)作为糖尿病的慢性合并症之一，在不同程度上影响患者的生活质量，为患者增加沉重的经济及心理负担，因此早期发现骨量减少，及时对骨质疏松症进行预防和治疗尤为重要。目前骨质疏松症诊断的金标准仍为双能X线吸收检测法(dual-energy X-ray absorptiometry, DXA)，但其易导致骨质疏松症的确诊率降低。定量CT (quanti-tative computed tomography, QCT)能够分开测量皮质骨与松质骨的体积骨密度，通过单独测定骨转换率高的松质骨，不受其他因素影响，更敏感地监测骨密度的动态变化，为临床上早期干预和治疗提供依据。因此未来QCT可能在我国糖尿病骨质疏松症的防治上能够发挥重要作用。

Abstract: With the prevalence of diabetes increasing year by year, osteoporosis (OP) as one of the chronic comorbidities of diabetes, affects the quality of life of patients to varying degrees, and increases the heavy economic and psychological burden of patients, therefore, it is particularly important to de-tect osteopenia early and prevent and treat osteoporosis in time. At present, the gold standard for the diagnosis of osteoporosis is still dual-energy X-ray absorptiometry (DXA), but it is easy to reduce the diagnosis rate of osteoporosis. Quantitative computed tomography (QCT) can measure the vol-ume bone density of cortical and cancellous bone separately. By measuring cancellous bone with high bone turnover rate separately, it is not affected by other factors and more sensitive to monitor the dynamic changes of bone density, providing a basis for early intervention and treatment in clin-ical practice. Therefore, in the future, QCT may play an important role in the prevention and treat-ment of diabetic osteoporosis in China.