基于伏邪理论探讨低氧性肺动脉高压肺血管重塑

Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension Based on the Theory of Hypoxia

摘要: 低氧性肺动脉高压(Hypoxic Pulmonary Hypertension, HPH)是一种由缺氧引起的极其复杂的心肺疾病，其病理机制极其复杂，其中，肺血管不可逆性重塑是HPH的显著病理特征之一，在HPH的发生发展中发挥着重要作用，因此尽早干预肺血管重塑是防治HPH及其并发症的关键所在。本文以伏邪为研究基础，认为伏邪藏匿于体内的过程与肺血管重塑有相似之处。脏腑功能失调是伏邪产生的基础，痰浊、瘀血是伏邪的关键组成部分，肺之络脉是伏邪的主要藏匿部位，而肺络受损则是伏邪致病的结果。本文将从中医学伏邪相关理论对肺血管重塑进行阐述，以期为HPH的治疗提供新的思路。

Abstract: Hypoxic pulmonary hypertension is an extremely complex cardiopulmonary disease caused by hypoxia, and its pathological mechanism is extremely complex. Irreversible remodeling of pulmonary vessels is one of the significant pathological features of HPH, and plays an important role in the occurrence and development of HPH. Therefore, early intervention in pulmonary vascular remodeling is the key to prevention and treatment of HPH and its complications. Based on the study of latent disease, this paper believes that the process of latent disease hiding in the body is similar to pulmonary vascular remodeling. The dysfunction of the zang-fu organs is the basis of the emergence of latent evil, the phlegm turbidness and blood stasis are the key components of latent evil, the lung complex is the main hiding place of latent evil, and the lung collateral damage is the result of latent evil. In order to provide new ideas for the treatment of HPH, this paper will expound pulmonary vascular remodeling based on the theory of pathogenic pathogens in TCM.