中药单体对银屑病IL-21功能干预的研究进展
Research Progress on Functional Intervention of Traditional Chinese Medicine Monomers on IL-21 in Psoriasis
DOI: 10.12677/TCM.2023.128330, PDF,   
作者: 于 帆, 闫景东*：黑龙江中医药大学研究生院，黑龙江 哈尔滨
关键词: 银屑病；IL-21；中药单体；Psoriasis； IL-21； Monomer of Traditional Chinese Medicine
摘要: 银屑病又俗称为“牛皮癣”，是较常见且易复发的一种自身免疫性疾病，也是伴随慢性炎症性的皮肤病。由于其具有较高的发病率和多程度的瘙痒，疾病过程迁延日久，困扰病患较其他多数皮肤病时间长，阶段治疗后容易加重且复发，重点是青壮年不易解脱，因此极大地影响患者皮肤舒适和精神健康，故银屑病是目前皮肤科范畴着重研究的疾病之一，研究发现，IL-21通过促进T细胞增殖、诱导Th17分化和增强Th17细胞功能参与银屑病的发病机制，并且部分中药单体和中药有效成分对IL-21的功能有调节作用，因此，本综述旨在总结IL-21与银屑病的关系、中药单体对IL-21功能及其信号通路干预，并探讨IL-21在银屑病的发病机理和治疗作用，以期为临床提供潜在的诊断、用药和治疗等多方面策略。
Abstract: Psoriasis, also known as “psoriasis”, is a common and easily relapsed autoimmune disease, as well as a chronic inflammatory skin disease. Because it has a high incidence rate and multiple degrees of itching, the disease process has lasted for a long time, and the trouble time for psoriasis is longer than that of most other skin diseases. After stage treatment, it is easy to aggravate and relapse, focusing on making Young adult difficult to get rid of, so it greatly affects the skin comfort and mental health of patients. Therefore, psoriasis is one of the diseases focused on in dermatology at present. The study found that IL-21 participates in the pathogenesis of psoriasis by promoting T cell proliferation, inducing Th17 differentiation, and enhancing Th17 cell function. Moreover, some traditional Chinese medicine monomers and active ingredients have regulatory effects on the function of IL-21. Therefore, this review aims to summarize the relationship between IL-21 and psoriasis, the intervention of traditional Chinese medicine monomers on IL-21 function and its signaling pathway, and explore the pathogenesis and therapeutic effect of IL-21 in psoriasis, in order to provide potential diagnostic, medication, and treatment strategies for clinical use.
文章引用：于帆, 闫景东. 中药单体对银屑病IL-21功能干预的研究进展[J]. 中医学, 2023, 12(8): 2199-2206. https://doi.org/10.12677/TCM.2023.128330

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