Micro-CT的工作原理及在骨微结构研究的应用
The Working Principle of Micro-CT and Its Application in the Study of Bone Microstructure
DOI: 10.12677/ACM.2023.1381889, PDF,   
作者: 马志豪*:内蒙古医科大学内蒙古临床医学院,内蒙古 呼和浩特;王 威#:内蒙古自治区人民医院急诊科,内蒙古 呼和浩特
关键词: Micro-CT骨小梁骨微结构Micro-CT Bone Trabecula Bone Microstructure
摘要: Micro-CT (Micro Computed Tomography,微计算机断层扫描技术)是一种非破坏性的三维成像技术,分辨率可达到微米(μm)级别,其广泛应用于骨骼、牙齿、生物材料等诸多领域,特别是在骨骼中的应用对于骨微结构及力学特征研究具有重要意义。本研究综述了Micro-CT的工作原理及其在骨微结构研究中的应用。
Abstract: Micro Computed Tomography is a non-destructive three-dimensional imaging technology, the reso-lution can reach micron (μm) level, it is widely used in bone, teeth, biomaterials and many other fields, especially the application in bone is of great significance to study bone microstructure and the mechanical characteristics. This study reviewed the working principle of Micro-CT and its ap-plication in the study of bone microstructure.
文章引用:马志豪, 王威. Micro-CT的工作原理及在骨微结构研究的应用[J]. 临床医学进展, 2023, 13(8): 13534-13539. https://doi.org/10.12677/ACM.2023.1381889

参考文献

[1] 金瑞, 曾勇明. 数字X线全景成像技术进展及临床应用[J]. 重庆医学, 2015, 44(4): 553-555.
[2] Hounsfield, G.N. (1973) Computerized Transverse Axial Scanning (Tomography): Part I. Description of System. The British Journal of Radiology, 46, 1016-1022.
[3] Pfeiffer, D., Pfeiffer, F. and Rummeny, E. (2020) Advanced X-Ray Imaging Technol-ogy. In: Schober, O., Kiessling, F. and Debus, J., Eds., Molecular Imaging in Oncology, Springer, Cham, 3-30. [Google Scholar] [CrossRef] [PubMed]
[4] Wang, J., Zhou, B., Liu, X.S., et al. (2015) Trabecular Plates and Rods Determine Elastic Modulus and Yield Strength of Human Trabecular Bone. Bone, 72, 71-80. [Google Scholar] [CrossRef] [PubMed]
[5] Cheng, X.G., Li, K., Ou, S.X., et al. (2017) Heterogeneity in Spi-nal Bone Mineral Density among Young Adults from Three Eastern Provincial Capital Cities in Mainland China. Journal of Clinical Densitometry, 20, 198-204. [Google Scholar] [CrossRef] [PubMed]
[6] 魏占英, 章振林. Micro-CT在骨代谢研究中骨微结构指标的解读及应用价值[J]. 中华骨质疏松和骨矿盐疾病杂志, 2018, 11(2): 200-205.
[7] Clark, D.P. and Badea, C.T. (2014) Micro-CT of Rodents: State-of-the-Art and Future Perspectives. European Journal of Medical Physics, 30, 619-634. [Google Scholar] [CrossRef] [PubMed]
[8] Ashton, J.R., West, J.L. and Badea, C.T. (2015) In vivo Small Animal Micro-CT Using Nanoparticle Contrast Agents. Frontiers in Pharmacology, 6, Article 256. [Google Scholar] [CrossRef] [PubMed]
[9] Vasquez, S.X., Shah, N. and Hoberman, A.M. (2012) Small Animal Imaging and Examination by Micro-CT. In: Barrow, P., Ed., Teratogenicity Testing, Humana Press, Totowa, 223-231. [Google Scholar] [CrossRef] [PubMed]
[10] Akhter, M.P. and Recker, R.R. (2021) High Resolution Imag-ing in Bone Tissue Research-Review. Bone, 143, Article ID: 115620. [Google Scholar] [CrossRef] [PubMed]
[11] Wehrli, F.W., Rajapakse, C.S., Magland, J.F. and Snyder, P.J. (2010) Mechanical Implications of Estrogen Supplementation in Early Postmenopausal Women. Journal of Bone and Mineral Research, 25, 1406-1414. [Google Scholar] [CrossRef] [PubMed]
[12] Borah, B., Dufresne, T.E., Chmielewski, P.A., et al. (2002) Risedronate Pre-serves Trabecular Architecture and Increases Bone Strength in Vertebra of Ovariectomized Minipigs as Measured by Three-Dimensional Microcomputed Tomography. Journal of Bone and Mineral Research, 17, 1139-1147. [Google Scholar] [CrossRef] [PubMed]
[13] 中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2022) [J]. 中国全科医学, 2023, 26(14): 1671-1691.
[14] Buie, H.R., Campbell, G.M., Klinck, R.J., Mac-Neil, J.A. and Boyd, S.K. (2007) Automatic Segmentation of Cortical and Trabecular Compartments Based on a Dual Threshold Technique for in vivo Micro-CT Bone Analysis. Bone, 41, 505-515. [Google Scholar] [CrossRef] [PubMed]
[15] Loundagin, L.L. and Cooper, D.M.L. (2022) Towards Novel Measurements of Remodeling Activity in Cortical Bone: Implications for Osteoporosis and Related Pharmaceutical Treatments. European Cells and Materials, 43, 202-227. [Google Scholar] [CrossRef
[16] Chen, C. and Kim, W.K. (2020) The Application of Micro-CT in Egg-Laying Hen Bone Analysis: Introducing an Automated Bone Separation Algorithm. Poultry Science, 99, 5175-5183. [Google Scholar] [CrossRef] [PubMed]
[17] Kennel, K.A., Sfeir, J.G. and Drake, M.T. (2020) Optimizing DXA to Assess Skeletal Health: Key Concepts for Clinicians. The Journal of Clinical Endocrinology & Metabolism, 105, 3784-3791. [Google Scholar] [CrossRef] [PubMed]
[18] Sebastian, H., David, H., Elisabeth, E., Djonov, V. and Arnold, A. (2021) Micro-CT Imaging of Thiel-Embalmed and Iodine-Stained Human Temporal Bone for 3D Modeling. Journal of Otolaryngology—Head & Neck Surgery, 50, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[19] Fonseca, H., Moreira-Gonçalves, D., Appell Coriolano, H.J. and Duarte, J.A. (2013) Bone Quality: The Determinants of Bone Strength and Fragility. Sports Medicine, 44, 37-53. [Google Scholar] [CrossRef] [PubMed]
[20] Shim, J., Iwaya, C., Ambrose, C.G., Suzuki, A. and Iwata, J. (2022) Micro-Computed Tomography Assessment of Bone Structure in Aging Mice. Scientific Reports, 12, Article No. 8117. [Google Scholar] [CrossRef] [PubMed]
[21] Tan, J., Labrinidis, A., Williams, R., Mian, M., Anderson, P.J. and Ranjitkar, S. (2022) Micro-CT—Based Bone Microarchitecture Analysis of the Murine Skull. In: Dworkin, S., Ed., Craniofacial Development, Humana, New York, 129-145. [Google Scholar] [CrossRef] [PubMed]
[22] Martin, S. and Ralph, M. (2008) Micro-Computed Tomogra-phy: A Method for the Non-Destructive Evaluation of the Three-Dimensional Structure of Biological Specimens. In: Westendorf, J.J., Ed., Osteoporosis, Humana Press, Totowa, 273-292. [Google Scholar] [CrossRef] [PubMed]
[23] Ning, B.H., Londono, I., Laporte, C. and Villemure, I. (2022) Validation of an in vivo Micro-CT-Based Method to Quantify Longitudinal Bone Growth of Pubertal Rats. Bone, 154, Article ID: 116207. [Google Scholar] [CrossRef] [PubMed]
[24] Michael, Z. and Paul, Z. (2021) Micro-CT Data of Early Physio-logical Cancellous Bone Formation in the Lumbar Spine of Female C57BL/6 Mice. Scientific Data, 8, Article No. 132. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, W., Pei, B.Q., Pei, Y.Y., et al. (2020) Biomechanical Ef-fects of Over Lordotic Curvature after Spinal Fusion on Adjacent Intervertebral Discs under Continuous Compressive Load. Clinical Biomechanics, 73, 149-156. [Google Scholar] [CrossRef] [PubMed]
[26] Wang, W., Pei, B.Q., Pei, Y.Y., et al. (2019) Biomechani-cal Effects of Posterior Pedicle Fixation Techniques on the Adjacent Segment for the Treatment of Thoracolumbar Burst Fractures: A Biomechanical Analysis. Computer Methods in Biomechanics and Biomedical Engineering, 22, 1083-1092. [Google Scholar] [CrossRef] [PubMed]
[27] 王黎, 王博. 不同力学条件下兔髌骨髌腱及腱止点的有限元建模及力学分析[J]. 中国组织工程研究, 2024, 28(12): 1829-1836.
[28] 李天清, 王军, 冯亚非, 等. 人体颈椎松质骨显微结构和力学性能的区域性差异研究[J]. 中国骨质疏松杂志, 2017, 23(5): 574-579.