肠易激综合征与小肠细菌过度生长的相关性研究进展
Research Progress on the Relationship between Irritable Bowel Syndrome and Small Intestinal Bacterial Overgrowth
DOI: 10.12677/ACM.2023.1381893, PDF,   
作者: 罗 绪*, 梁远峰, 王超雷, 陈雪晴:广西中医药大学第一临床医学院,广西 南宁;彭卓嵛#, 陈月桥:广西中医药大学第一附属医院脾胃病科,广西 南宁
关键词: 肠易激综合征小肠细菌过度生长研究进展Iirritable Bowel Syndrome Bacterial Overgrowth in the Small Intestine Research Progress
摘要: 肠易激综合征(Irritable Bowel Syndrome, IBS)是消化系统常见疾病之一,目前,IBS缺乏确定的器质性改变及相关的实验室检查指标诊断证据,病因尚不明确,而小肠细菌过度生长(small intestinal bacterial overgrowth, SIBO)可导致IBS系列症状,根治小肠细菌过度生长后IBS的部分症状可缓解,因此本文就近五年IBS与小肠细菌过度生长之间相互关系的文献提供新的研究进展。
Abstract: Irritable bowel syndrome (IBS) is one of the common diseases of the digestive system. At present, IBS lacks confirmed organic changes and relevant laboratory test indicators for diagnosis, and the etiology is still unclear. Small intestinal bacteria overgrowth (SIBO) can lead to a series of symptoms of IBS, and some symptoms of IBS can be relieved after radical treatment of small intestinal bacte-rial overgrowth. Therefore, this article provides new research progress on the relationship between IBS and small intestinal bacterial overgrowth in the past five years.
文章引用:罗绪, 彭卓嵛, 梁远峰, 王超雷, 陈雪晴, 陈月桥. 肠易激综合征与小肠细菌过度生长的相关性研究进展[J]. 临床医学进展, 2023, 13(8): 13555-13560. https://doi.org/10.12677/ACM.2023.1381893

参考文献

[1] Ford, A.C., Moayyedi, P., Chey, W.D., et al. (2018) American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome. American Journal of Gastroenterology, 113, 1-18. [Google Scholar] [CrossRef] [PubMed]
[2] Ford, A.C., Sperber, A.D., Corsetti, M. and Camilleri, M. (2020) Irritable Bowel Syndrome. The Lancet, 396, 1675-1688. [Google Scholar] [CrossRef
[3] Camilleri, M., Zhernakova, A., Bozzarelli, I. and D’Amato, M. (2022) Genetics of Irritable Bowel Syndrome: Shifting Gear via Biobank-Scale Studies. Nature Reviews Gastroen-terology & Hepatology, 19, 689-702. [Google Scholar] [CrossRef] [PubMed]
[4] Black, C.J. and Ford, A.C. (2020) Global Burden of Irritable Bowel Syndrome: Trends, Predictions and Risk Factors. Nature Reviews Gastroenterology & Hepatology, 17, 473-486. [Google Scholar] [CrossRef] [PubMed]
[5] Aguilera-Lizarraga, J., Hussein, H. and Boeckxstaens, G.E. (2022) Immune Activation in Irritable Bowel Syndrome: What Is the Evidence? Nature Reviews Immunology, 22, 674-686. [Google Scholar] [CrossRef] [PubMed]
[6] Vasant, D.H., Paine, P.A., Black, C.J., et al. (2021) British So-ciety of Gastroenterology Guidelines on the Management of Irritable Bowel Syndrome. Gut, 70, 1214-1240. [Google Scholar] [CrossRef] [PubMed]
[7] Ghoshal, U. C., Nehra, A., Mathur, A., and Rai, S. (2020) A Me-ta-Analysis on Small Intestinal Bacterial Overgrowth in Patients with Different Subtypes of Irritable Bowel Syndrome. Journal of Gastroenterology and Hepatology, 35, 922-931. [Google Scholar] [CrossRef] [PubMed]
[8] Losurdo, G., D’Abramo, F., Indellicati, G., et al. (2020) The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders. International Journal of Molecular Sciences, 21, Article No. 3531. [Google Scholar] [CrossRef] [PubMed]
[9] Wijarnpreecha, K., Werlang, M.E., Watthanasuntorn, K., Panjawatanan, P., Cheungpasitporn, W., Gomez, V., Lukens, F.J. and Ungprasert, P. (2020) Obesity and Risk of Small Intestine Bacte-rial Overgrowth: A Systematic Review and Meta-Analysis. Digestive Diseases and Sciences, 65, 1414-1422. [Google Scholar] [CrossRef] [PubMed]
[10] Pimentel, M., Saad, R.J., Long, M.D. and Rao, S. (2020) ACG Clinical Guideline Small Intestinal Bacterial Overgrowth. The American Journal of Gastroenterology, 115, 165-178. [Google Scholar] [CrossRef] [PubMed]
[11] Takakura, W. and Pimentel, M. (2020) Small Intestinal Bac-terial Overgrowth and Irritable Bowel Syndrome—An Update. Frontiers in Psychiatry, 11, Article 664. [Google Scholar] [CrossRef] [PubMed]
[12] Chen, B., Kim, J.J.-W., Zhang, Y., Du, L. and Dai, N. (2018) Prev-alence and Predictors of Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. Journal of Gastroenterology, 53, 807-818. [Google Scholar] [CrossRef] [PubMed]
[13] Wu, K.-Q., Sun, W.-J., Li, N., et al. (2019) Small Intestinal Bacterial Overgrowth Is Associated with Diarrhea-Predominant Irritable Bowel Syndrome by Increasing Mainly Prevotella Abundance. Scandinavian Journal of Gastroenterology, 54, 1419-1425. [Google Scholar] [CrossRef] [PubMed]
[14] Gandhi, A., Shah, A., Jones, M.P., et al. (2021) Methane Positive Small Intestinal Bacterial Overgrowth in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. Gut Microbes, 13, Article 1933313. [Google Scholar] [CrossRef] [PubMed]
[15] Yang, M., Zhang, L., Hong, G., et al. (2020) Duodenal and Rectal Mucosal Microbiota Related to Small Intestinal Bacterial Overgrowth in Diarrhea-Predominant Irritable Bowel Syndrome. Journal of Gastroenterology and Hepatology, 35, 795-805. [Google Scholar] [CrossRef] [PubMed]
[16] Burns, G.L., Talley, N.J. and Keely, S. (2022) Immune Responses in the Ir-ritable Bowel Syndromes: Time to Consider the Small Intestine. BMC Medicine, 20, Article No. 115. [Google Scholar] [CrossRef] [PubMed]
[17] Singh, P. and Lembo, A. (2021) Emerging Role of the Gut Mi-crobiome in Irritable Bowel Syndrome. Gastroenterology Clinics of North America, 50, 523-545. [Google Scholar] [CrossRef] [PubMed]
[18] Shah, A., Talley, N.J., Jones, M., et al. (2020) Small Intestinal Bac-terial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. The American Journal of Gastroenterology, 115, 190-201. [Google Scholar] [CrossRef] [PubMed]
[19] Ding, X.W., Liu, Y.X., Fang, X.C., et al. (2017) The Rela-tionship between Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome. European Review for Medical and Pharmacological Sciences, 21, 5191-5196.
[20] Lee, S.-H., Joo, N.-S., Kim, K.-M. and Kim, K.-N. (2018) The Thera-peutic Effect of a Multistrain Probiotic on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study. Gastroenter-ology Research and Practice, 2018, Article ID: 8791916. [Google Scholar] [CrossRef] [PubMed]
[21] Stefanolo, J.P., Tevez, A., Manresa, M.M., et al. (2019) Therapeutic Response to Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome (IBS). Is It Useful to Test For? Gastroenterology, 156, S-190-S-191. [Google Scholar] [CrossRef
[22] Gu, P., Patel, D., Lakhoo, K., et al. (2020) Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis. Digestive Diseases and Sciences, 65, 2388-2396. [Google Scholar] [CrossRef] [PubMed]
[23] Lee, S.-H., Cho, D.-Y., Joo, N.-S. and Kim, K.-N. (2019) Effect of Eradicating Hydrogen-Forming Small Intestinal Bacterial Overgrowth with Rifaximin on Body Weight Change. Medi-cine, 98, e18396. [Google Scholar] [CrossRef
[24] Zhuang, X., Tian, Z., Luo, M. and Xiong, L. (2020) Short-Course Rifaximin Therapy Efficacy and Lactulose Hydrogen Breath Test in Chinese Patients with Diar-rhea-Predominant Irritable Bowel Syndrome. BMC Gastroenterology, 20, Article No. 187. [Google Scholar] [CrossRef] [PubMed]
[25] Tuteja, A.K., Talley, N.J., Stoddard, G.J. and Verne, G.N. (2019) Double-Blind Placebo-Controlled Study of Rifaximin and Lactulose Hydrogen Breath Test in Gulf War Veterans with Ir-ritable Bowel Syndrome. Digestive Diseases and Sciences, 64, 838-845. [Google Scholar] [CrossRef] [PubMed]
[26] Leventogiannis, K., Gkolfakis, P., Spithakis, G., et al. (2018) Ef-fect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intes-tinal Bacterial Overgrowth. Probiotics and Antimicrobial Proteins, 11, 627-634. [Google Scholar] [CrossRef] [PubMed]
[27] Su, T., Lai, S., Lee, A., He, X. and Chen, S. (2017) Me-ta-Analysis: Proton Pump Inhibitors Moderately Increase the Risk of Small Intestinal Bacterial Overgrowth. Journal of Gastroenterology, 53, 27-36. [Google Scholar] [CrossRef] [PubMed]
[28] Schmulson, M.J. and Frati-Munari, A.C. (2019) Síntomas intestinales en pacientes que reciben inhibidores de bomba de protones (IBP). Resultados de una encuesta multicéntrica en México. Revista de Gastroenterología de México, 84, 44-51. [Google Scholar] [CrossRef] [PubMed]
[29] Wielgosz-Grochowska, J.P., Domanski, N. and Drywien, M.E. (2022) Efficacy of an Irritable Bowel Syndrome Diet in the Treatment of Small Intestinal Bacterial Overgrowth: A Narra-tive Review. Nutrients, 14, Article No. 3382. [Google Scholar] [CrossRef] [PubMed]
[30] Wright, C., Dooley, M. and Leeson, H. (2021) Eradication of Small In-testinal Bacterial Overgrowth in Irritable Bowel Syndrome Using Herbal Therapy: A Case Report. International Journal of Functional Nutrition, 2, Article No. 13. [Google Scholar] [CrossRef