胱抑素C与胰岛功能

Cystatin C and Islet Function

摘要: 目的：探讨2型糖尿病(T2DM)患者血清胱抑素C (Cys C)和胰岛功能的相关性。方法：选取2014年~2015年参加中国沿海地区的普通人群流行性病学调查的3091例和2017年~2019年就诊于青岛大学附属医院的住院患者1039例，共4127例。采用Spearman相关分别在非糖尿病和糖尿病人群中对胱抑素C与空腹C肽、空腹胰岛素、HOMA-IR、HOMA-β进行相关性分析；采用Logistic回归分析DKD组中胱抑素C与C肽、胰岛素、HOMA-IR、HOMA-β的线性回归关系。结果：非糖尿病人群与糖尿病人群两组的胱抑素水平没有显著差异(P > 0.05)；DKD组胱抑素C水平显著高于非DKD组(P < 0.05)；在DKD组，胱抑素C与空腹C肽、空腹胰岛、HOMA-IR、HOMA-β为正相关关系(P < 0.05)；在非DKD组，胱抑素C与胰岛素水平呈正相关，与HOMA-IR呈负相关关系(P < 0.05)。结论：在DKD中，我们认为Cys C、C肽和HOMA-IR是相互因果的，Cys C升高可能是HOMA-IR的代偿性反应。

Abstract: Objective: To analyze the correlation between serum cystatin C (Cys C) and islet function in different populations. Methods: We selected 3091 people who participated in the general population epide-miological survey in coastal areas of China from 2014 to 2015 and 1039 inpatients who visited the Affiliated Hospital of Qingdao University from 2017 to 2019, a total of 4127 people. Spearman’s correlation was used to correlate cystatin C with fasting C-peptide, fasting insulin, HOMA-IR, and HOMA-β. Logistic regression was used to analyze the relationship between cystatin C and C-peptide in group DKD, insulin, HOMA-IR, and HOMA-β by linear regression. Results: There was no significant difference in cystatin level between non diabetes group and diabetes group (P > 0.05); The level of cystatin C in DKD group was significantly higher than that in non-DKD group (P < 0.05); In DKD group, cystatin C and fasting C-peptide, fasting islets, HOMA-IR, HOMA-β are positive correlation (P < 0.05); In non-DKD group, cystatin C was positively correlated with insulin level and negatively cor-related with HOMA-IR (P < 0.05). Conclusion: In DKD, we believe that Cys C, C-peptide and HOMA-IR are mutually causal, and the increase of Cys C may be a compensatory response of HOMA-IR.