幽门螺杆菌(Hp)感染与焦虑抑郁状态的相关性研究

Study on the Helicobacter pylori Infection and the Correlation Study of Anxiety-Depression Condition

摘要: 幽门螺杆菌(Helicobacter pylori, Hp)是一种世界上感染最普遍的病原体之一，据最新研究报道，Hp不仅与大部分胃肠相关疾病有密切的关系，甚至跟胃肠外其他系统疾病也有一定的相关性。有研究表明，幽门螺杆菌感染可以经过脑–肠轴(Brain-gut axis, BGA)刺激神经递质及激素释放，从而影响神经调节、内分泌和免疫反应，进而影响患者的思维和心理活动，目前已有研究证实幽门螺杆菌感染是阿尔兹海默症(AD)的危险因素。本文将针对于Hp感染的各项影响因素，尤其是其与焦虑抑郁状态相关性研究及治疗做一综述。

Abstract: Helicobacter pylori (H. pylori) is one of the most commonly infected pathogens in the world, accord-ing to the latest research report, H. pylori not only had a close relationship with gastric disease, but it also had a certain correlation with other gastrointestinal system diseases. Research has shown that, H. pylori infection can stimulate the release of neurotransmitters and hormones through the Brain-gut axis (BGA), thus affecting neuromodulation, endocrine and immune responses, which af-fects the thinking and psychological activities of patients. Currently, research has confirmed that H. pylori infection is a risk factor for Alzheimer’s disease (AD). This article will review the various in-fluencing factors of H. pylori infection, especially its correlation with Anxiety-Depression condition, as well as its treatment.