脂质代谢与乳腺癌的关系研究进展
Research Progress on the Relationship between Lipid Metabolism and Breast Cancer
DOI: 10.12677/ACM.2023.1381920, PDF,   
作者: 赵 璠, 张雪云*:青海大学附属医院肿瘤外科,青海 西宁
关键词: 脂质代谢脂质代谢与乳腺癌Lipid Metabolism Lipid Metabolism and Breast Cancer
摘要: 正常的脂质代谢在生物体的发育发展中维持稳态,在恶性转化过程中,细胞的脂质代谢发生根本性变化,因此脂质代谢的改变是癌症的突出特征。讨论了脂质代谢紊乱和乳腺癌的研究,本文就脂质代谢与乳腺癌的研究进展进行综述,期望为更近一步研究其关系,为治疗乳腺癌提供参考依据。
Abstract: Normal lipid metabolism maintains a steady state during the development of organisms. In the process of malignant transformation, cell lipid metabolism undergoes fundamental changes. Therefore, changes in lipid metabolism are prominent features of cancer. The research on lipid me-tabolism disorder and breast cancer was discussed. This article reviewed the research progress of lipid metabolism and breast cancer, hoping to provide a reference for further research on its rela-tionship and treatment of breast cancer.
文章引用:赵璠, 张雪云. 脂质代谢与乳腺癌的关系研究进展[J]. 临床医学进展, 2023, 13(8): 13745-13749. https://doi.org/10.12677/ACM.2023.1381920

参考文献

[1] Arhofer, K.G. (2016) The Treatment of Disorders of Lipid Metabolism. Deutsches Ärzteblatt International, 113, 261-268. [Google Scholar] [CrossRef] [PubMed]
[2] Menendez, J.A. and Lupu, R. (2007) Fatty Acid Synthase and the Lipogenic Phenotype in Cancer Pathogenesis. Nature Reviews Cancer, 7, 763-777. [Google Scholar] [CrossRef] [PubMed]
[3] Farese Jr., R.V. and Walther, T.C. (2009) Lipid Droplets Finally Get a Little R-E-S-P-E-C-T. Cell, 139, 855-860. [Google Scholar] [CrossRef] [PubMed]
[4] Accioly, M.T., Pacheco, P., Maya-Monteiro, C.M., et al. (2008) Li-pid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells. Cancer Research, 68, 1732-1740. [Google Scholar] [CrossRef
[5] Khasawneh, J., Schulz, M.D., Walch, A., Rozman, J., Hra-be, de Angelis, M., Klingenspor, M., Buck, A., Schwaiger, M., Saur, D., Schmid, R.M., Klöppel, G., Sipos, B., Greten, F.R. and Arkan, M.C. (2009) Inflammation and Mitochondrial Fatty Acid β-Oxidation Link Obesity to Early Tumor Promotion. Proceedings of the National Academy of Sciences of the United States of America, 106, 3354-3359. [Google Scholar] [CrossRef] [PubMed]
[6] Nomura, D.K., Long, J.Z., Niessen, S., Hoover, H.S., Ng, S.W. and Cravatt, B.F. (2010) Monoacylglycerol Lipase Regulates a Fatty Acid Network That Promotes Cancer Pathogenesis. Cell, 140, 49-61. [Google Scholar] [CrossRef] [PubMed]
[7] Sell, C. (2003) Caloric Restriction and Insulin-Like Growth Factors in Aging and Cancer. Hormone and Metabolic Research, 35, 705-711. [Google Scholar] [CrossRef] [PubMed]
[8] Evans, W.J., Morley, J.E., Argilés, J., Bales, C., Baracos, V., Gut-tridge, D., Jatoi, A., Kalantar-Zadeh, K., Lochs, H., Mantovani, G., Marks, D., Mitch, W.E., Muscaritoli, M., Najand, A., Ponikowski, P., Rossi, Fanelli, F., Schambelan, M., Schols, A., Schuster, M., Thomas, D., Wolfe, R. and Anker, S.D. (2008) Cachexia: A New Definition. Clinical Nutrition, 27, 793-799. [Google Scholar] [CrossRef] [PubMed]
[9] Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Van, Veldhoven, P.P., Waltregny, D., Daniëls, V.W., Machiels, J., Vanderhoydonc, F., Smans, K., Waelkens, E., Verhoeven, G. and Swinnen, J.V. (2010) De Novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation. Cancer Research, 70, 8117-8126. [Google Scholar] [CrossRef
[10] Vander Heiden, M.G., Cantley, L.C. and Thompson, C.B. (2009) Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science, 324, 1029-1033. [Google Scholar] [CrossRef] [PubMed]
[11] Buzzai, M., Bauer, D.E., Jones, R.G., Deberardinis, R.J., Hatzi-vassiliou, G., Elstrom, R.L. and Thompson, C.B. (2005) The Glucose Dependence of Akt-Transformed Cells Can Be Reversed by Pharmacologic Activation of Fatty Acid β-Oxidation. Oncogene, 24, 4165-4173. [Google Scholar] [CrossRef] [PubMed]
[12] Bray, F., Ferlay, J., Laversanne, M., Brewster, D.H., Gombe Mbalawa, C., Kohler, B., Piñeros, M., Steliarova-Foucher, E., Swaminathan, R., Antoni, S., Soerjomataram, I. and Forman, D. (2015) Cancer Incidence in Five Continents: Inclusion Criteria, Highlights from Volume X and the Global Status of Cancer Registration. International Journal of Cancer, 137, 2060-2071. [Google Scholar] [CrossRef] [PubMed]
[13] Khan, S., Shukla, S., Sinha, S. and Meeran, S.M. (2013) Role of Adipokines and Cytokines in Obesity-Associated Breast Cancer: Therapeutic Targets. Cytokine & Growth Factor Reviews, 24, 503-513. [Google Scholar] [CrossRef] [PubMed]
[14] Ligibel, J.A., Alfano, C.M., Courneya, K.S., De-mark-Wahnefried, W., Burger, R.A., Chlebowski, R.T., Fabian, C.J., Gucalp, A., Hershman, D.L., Hudson, M.M., Jones, L.W., Kakarala, M., Ness, K.K., Merrill, J.K., Wollins, D.S. and Hudis, C.A. (2014) American Society of Clinical Oncology Position Statement on Obesity and Cancer. Journal of Clinical Oncology, 32, 3568-3574. [Google Scholar] [CrossRef
[15] Arce-Salinas, C., Aguilar-Ponce, J.L., Villarreal-Garza, C., La-ra-Medina, F.U., Olvera-Caraza, D., Alvarado Miranda, A., Flores-Díaz, D. and Mohar, A. (2014) Overweight and Obesity as Poor Prognostic Factors in Locally Advanced Breast Cancer Patients. Breast Cancer Research and Treatment, 146, 183-188. [Google Scholar] [CrossRef] [PubMed]
[16] Dirat, B., Bochet, L., Dabek, M., Daviaud, D., Dauvillier, S., Majed, B., Wang, Y.Y., Meulle, A., Salles, B., Le, Gonidec, S., Garrido, I., Escourrou, G., Valet, P. and Muller, C. (2011) Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion. Cancer Research, 71, 2455-2465. [Google Scholar] [CrossRef
[17] Louie, S.M., Roberts, L.S. and Nomura, D.K. (2013) Mechanisms Linking Obesity and Cancer. Biochimica et Biophysica Acta, 1831, 1499-1508. [Google Scholar] [CrossRef] [PubMed]
[18] Zaidi, N., Lupien, L., Kuemmerle, N.B., et al. (2013) Lipogenesis and Lipolysis: The Pathways Exploited by the Cancer Cells to Acquire Fatty Acids. Progress in Lipid Research, 52, 585-589. [Google Scholar] [CrossRef] [PubMed]
[19] Boyd, N.F., Stone, J., Vogt, K.N., Connelly, B.S., Martin, L.J. and Minkin, S. (2003) Dietary Fat and Breast Cancer Risk Revisited: A Meta-Analysis of the Published Literature. Brit-ish Journal of Cancer, 89, 1672-1685. [Google Scholar] [CrossRef] [PubMed]
[20] Yang, B., Ren, X.-L., Fu, Y.-Q., Gao, J.-L. and Li, D. (2014) Ratio of n-3/n-6 PUFAs and Risk of Breast Cancer: A Meta-Analysis of 274135 Adult Females from 11 Independent Prospective Studies. BMC Cancer, 14, Article No. 105. [Google Scholar] [CrossRef] [PubMed]
[21] Zheng, J.-S., Hu, X.-J., Zhao, Y.-M., Yang, J. and Li, D. (2013) Intake of Fish and Marine N-3 Polyunsaturated Fatty Acids and Risk of Breast Cancer: Meta-Analysis of Data from 21 Independent Prospective Cohort Studies. BMJ, 346, Article No. f3706. [Google Scholar] [CrossRef] [PubMed]
[22] Liu, J. and Ma, D.W. (2014) The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer. Nutrients, 6, 5184-223. [Google Scholar] [CrossRef] [PubMed]