Tp-e/QT比值在临床中的应用研究进展
Research Progress on the Application of Tp-e/QT Ratio in Clinical Practice
DOI: 10.12677/MD.2023.133050, PDF,   
作者: 金 萌, 李 飞:延安大学附属医院心血管内科,陕西 延安
关键词: Tp-e/QT心律失常综述Tp-e/QT Arrhythmia Review
摘要: Tp-e间期是指心电图T波顶点到T波终点之间的时间间期,是QT间期的终末组成部分,能够代表在绝大部分心室肌复极后小部分心室肌间复极的离散度,Tp-e/QT比值指Tp-e间期与QT间期的比值,是比Tp-e更敏感的预测心律失常的指标,因为其可以不受心率变异和QT间期个体间波动影响,是心源性猝死的可能性重要预警。现对其研究予以综述,望对临床中恶性心律失常等的发生提供预测价值。
Abstract: Tp-e interval refers to the time interval between the T wave apex and T wave endpoint of electro-cardiogram, which is the final component of QT interval and can represent the dispersion of re-polarization between a small part of ventricular muscles after repolarization of most ventricular muscles. Tp-e/QT ratio refers to the ratio of Tp-e interval to QT interval. Tp-e is a more sensitive predictor of arrhythmia than TP-E because it is independent of heart rate variability and QT inter-individual fluctuations, and is an important predictor of sudden cardiac death. This paper reviews its research and hopes to provide predictive value for the occurrence of malignant arrhythmia in clinic.
文章引用:金萌, 李飞. Tp-e/QT比值在临床中的应用研究进展[J]. 医学诊断, 2023, 13(3): 328-334. https://doi.org/10.12677/MD.2023.133050

参考文献

[1] Xia, Y.L., Liang, Y.C., Kongstad, O., et al. (2005) In Vivo Validation of the Coincidence of the Peak and End of the T Wave with Full Repolarization of the Epicardium and Endocardium in Swine. Heart Rhythm, 2, 162-169.
[2] 张璐. STEMI患者PCI术后STE、Tp-e/QT比值预测主要不良心血管事件的研究[D]: [硕士学位论文]. 郑州: 河南大学, 2020.[CrossRef
[3] Gupta, P., Patel, C., Patel, H., et al. (2008) T(p-e)/QT Ratio as an Index of Arrhythmogenesis. Journal of Electrocardiology, 41, 567-574. [Google Scholar] [CrossRef] [PubMed]
[4] 罗进, 贺琳, 欧阳泽伟. Tp-e间期的研究进展及其在冠心病中的临床应用[J]. 中国心血管病研究, 2020, 18(3): 273-276+288.
[5] Yan, G.X. and Antzelevitch, C. (1998) Cellular Basis for the Normal T Wave and the Electrocardiographic Manifestations of the Long-QT Syndrome. Circulation, 98, 1928-1936. [Google Scholar] [CrossRef
[6] 赵香梅, 秦历杰, 杨蕾, 李法良, 陈龙. Tp-e/QT比值对急性药物中毒患者心脏不良事件的预测价值[J]. 中国急救医学, 2020, 40(6): 480-484.
[7] 吴月娥, 胡泽平, 马兰, 张浩, 徐心怡. 梗死区Tp-ec及Tp-e/QT值对ST段抬高型心肌梗死患者的预后价值分析[J]. 安徽医科大学学报, 2020, 55(5): 790-794. [Google Scholar] [CrossRef
[8] Wu, Y.E., Ma, L. and Hu, Z.P. (2022) Prognostic Value of infarct-Related-Lead Tpeak-Tend/QT Ratio in Patients with ST-Segment Elevation Myocardial Infarction. Heart Vessels, 37, 539-548. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, X.P., Wu, S., Gao, C.Y., et al. (2017) Tpeak-Tend Dispersion as a Predictor for Malignant Arrhythmia Events in Patients with Vasospastic Angina. International Journal of Car-diology, 249, 61-65. [Google Scholar] [CrossRef] [PubMed]
[10] Karacop, E. and Enhos, A. (2020) Predictive Role of Ventricular Re-polarization Parameters for the Occurrence of Complete Heart Block in Patients Undergoing Transcatheter Aortic Valve Implan-tation. Ann Noninvasive Electrocardiol, 25, e12734. [Google Scholar] [CrossRef] [PubMed]
[11] Tashiro, N., Muneuchi, J., Ezaki, H., et al. (2022) Ventricular Repolarization Dispersion Is a Potential Risk for the Development of Life-Threatening Ar-rhythmia in Children with Hypertrophic Cardiomyopathy. Pediatric Cardiology, 43, 1455-1461. [Google Scholar] [CrossRef] [PubMed]
[12] Aladag, N., Guner, A., Arslan, C., et al. (2022) Assessment of Proarrhythmic Ventricular Electrophysiological Remodeling in Patients with Rheumatoid Arthritis. Herz, 47, 465-470. [Google Scholar] [CrossRef] [PubMed]
[13] Hidayet, Ş., Demir, V., Turan, Y., Gürel, G. and Taşolar, M.H. (2019) Evaluation of Tp-e Interval, Tp-e/QT Ratio, and Tp-e/QTc Ratio in Patients with Behçet’s Disease. The Anatolian Journal of Cardiology, 22, 85-90. [Google Scholar] [CrossRef
[14] Arısoy, A., Karaman, K., Karayakalı, M., et al. (2017) Evalua-tion of Ventricular Repolarization Features with Novel Electrocardiographic Parameters (Tp-e, Tp-e/QT) in Patients with Psoria-sis. The Anatolian Journal of Cardiology, 18, 397-401. [Google Scholar] [CrossRef
[15] Yayla, Ç., Yayla, M.E., Yayla, K.G., Ilgen, U., Akboğa, M.K. and Düzgün, N. (2016) The Assessment of Tp-e Interval and Tp-e/QT Ratio in Patients with Systemic Sclerosis. Archives of Rheumatology, 31, 139-144. [Google Scholar] [CrossRef
[16] Acar, G., Yorgun, H,. Inci, M.F., et al. (2014) Evaluation of Tp-e Interval and Tp-e/QT Ratio in Patients with Ankylosing Spondylitis. Modern Rheumatology, 24, 327-330. [Google Scholar] [CrossRef] [PubMed]
[17] Ece, İ., Koçoğlu, M., Kavurt, A.V., et al. (2021) Assessment of Car-diac Arrhythmic Risk in Children with Covid-19 Infection. Pediatric Cardiology, 42, 264-268. [Google Scholar] [CrossRef] [PubMed]
[18] Cosgun, A., Oren, H. and Turkkani, M.H. (2020) The Relationship between Systolic Pulmonary Arterial Pressure and Tp-e Interval, Tp-e/QT, and Tp-e/QTc Ratios in Patients with Newly Diag-nosed Chronic Obstructive Pulmonary Disease. Annals of Noninvasive Electrocardiology, 25, e12691. [Google Scholar] [CrossRef] [PubMed]
[19] Sökmen, E., Özbek, S.C., Çelik, M., Sivri, S., Metin, M. and Avcu, M. (2018) Changes in the Parameters of Ventricular Repolarization during Preapnea, Apnea, and Postapnea Periods in Patients with Ob-structive Sleep Apnea. Pacing and Clinical Electrophysiology, 41, 762-766. [Google Scholar] [CrossRef] [PubMed]
[20] Zhao, D., Liang, B., Peng, J., et al. (2021) Tp-e and (Tp-e)/QT Ratio as a Non-Invasive Risk Factors for Malignant Ventricular Ar-rhythmia in Patients with Idiopathic Ventricular Premature Complexes. Journal of Clinical Laboratory Analysis, 35, e23636. [Google Scholar] [CrossRef] [PubMed]
[21] Cekirdekci, E.I. and Bugan, B. (2019) Can Abnormal Dispersion of Ventricular Repolarization Be a Predictor of Mortality in Arrhythmogenic Right Ventricular Cardiomyopathy: The Importance of Tp-e In-terval. Annals of Noninvasive Electrocardiology, 24, e12619. [Google Scholar] [CrossRef] [PubMed]
[22] Karaman, K., Karayakali, M., Arisoy, A., et al. (2018) Is There Any Relationship between Myocardial Repolarization Parameters and the Frequency of Ventricular Premature Contractions? Arquivos Brasileiros de Cardiologia, 110, 534-541. [Google Scholar] [CrossRef] [PubMed]
[23] Alizade, E., Yesin, M., Yazicioğlu, M.V., et al. (2017) Evaluation of Tp-e In-terval, Tp-e/QT Ratio, and Tp-e/QTc Ratio in Patients with Asymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy. Annals of Noninvasive Electrocardiology, 22, e12362. [Google Scholar] [CrossRef] [PubMed]
[24] Karaman, K., Altunkaş, F., Çetin, M., et al. (2015) New Markers for Ventricular Repolarization in Coronary Slow Flow: Tp-e Interval, Tp-e/QT Ratio, and Tp-e/QTc Ratio. Annals of Noninvasive Electrocardiology, 20, 338-344. [Google Scholar] [CrossRef] [PubMed]
[25] Gayretli Yayla, K., Yayla, Ç., Erdöl, M.A., et al. (2021) Tp-e/QTc Ratio, SYNTAX, and GRACE Score in Patients Who Underwent Coronary Angiography Owing to Acute Coronary Syndrome. The Anatolian Journal of Cardiology, 25, 887-895. [Google Scholar] [CrossRef
[26] Ajibare, A.O., Olabode, O.P., Fagbemiro, E.Y., et al. (2020) Assessment of Ventricular Repolarization in Sickle Cell Anemia Patients: The Role of QTc Interval, Tp-e Interval and Tp-e/QTc Ratio and Its Gender Implication. Vascular Health and Risk Management, 16, 525-533. [Google Scholar] [CrossRef
[27] Unal Evren, E., Cekirdekci, E.I., Evren, H., et al. (2020) Abnor-mal Dispersion of Ventricular Repolarization as a Risk Factor in Patients with Human Immunodeficiency Virus: Tp-e Interval, Tp-e/QTc Ratio. Medical Principles and Practice, 29, 544-550. [Google Scholar] [CrossRef] [PubMed]
[28] Ünal, S., Yayla, Ç., Açar, B., et al. (2018) Tp-e Interval and Tp-e/QT Ratio in Patients with Human Immunodeficiency Virus. Journal of Infec-tion and Public Health, 11, 35-38. [Google Scholar] [CrossRef] [PubMed]
[29] Tanrıverdi, Z., Çöllüoğlu, T., Ünal, B., Dursun, H. and Kaya, D. (2018) The Effect of Transcatheter Aortic Valve Implantation on Tp-e Interval, Tp-e/QT and Tp-e/QTc Ratios, and Tp-e Dispersion in Patients with Severe Aortic Stenosis. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 26, 65-72. [Google Scholar] [CrossRef] [PubMed]
[30] Ozdemir, R., Isguder, R., Kucuk, M., et al. (2016) A Valuable Tool in Predicting Poor Outcome due to Sepsis in Pediatric Intensive Care Unit: Tp-e/QT Ratio. Journal of Tropical Pediatrics, 62, 377-384. [Google Scholar] [CrossRef] [PubMed]
[31] Kirbas, A., Kirbas, O., Daglar, K., et al. (2016) Novel Indexes of Arrhythmo-genesis in Preeclampsia: QT Dispersion, Tp-e Interval, and Tp-e/QT Ratio. Gestational Hypertension, 6, 38-41. [Google Scholar] [CrossRef] [PubMed]
[32] Demir, V., Hidayet, S., Turan, Y. and Ede, H. (2020) Acute Effects of Electronic Cigarette Smoking on Ventricular Repolarization in Adults. African Health Sciences, 20, 1793-1799. [Google Scholar] [CrossRef] [PubMed]
[33] Yıldız, S.S., Sutaşır, M.N., Sığırcı, S., et al. (2019) Acute Effects of Synthetic Cannabinoids on Ventricular Repolarization Parameters. Turk Kardiyoloji Dernegi Arsivi, 47, 384-390. [Google Scholar] [CrossRef] [PubMed]
[34] Akcay, M. (2018) The Effect of Moderate Altitude on Tp-e Interval, Tp-e/QT, QT, cQT and P-Wave Dispersion. Journal of Electrocardiology, 51, 929-933. [Google Scholar] [CrossRef] [PubMed]
[35] Karakulak, U.N., Yilmaz, O.H., Tutkun, E., Gunduzoz, M. and Ercan Onay, E. (2017) Comprehensive Electrocardiographic Analysis of Lead Exposed Workers: An Arrhythmic Risk Assess-ment Study. Annals of Noninvasive Electrocardiology, 22, e12376. [Google Scholar] [CrossRef] [PubMed]
[36] Duyuler, S., Türker Duyuler, P. and Batur, M.K. (2016) Impact of Iron and Homocysteine Levels on T Peak-to-End Interval and Tp-e/QT Ratio in Elite Athletes. Annals of Noninvasive Electrocardiology, 21, 557-565. [Google Scholar] [CrossRef] [PubMed]
[37] Cosgun, A. and Oren, H. (2020) Variation of Tpeak-End, Corrected Tpeak-End, QT, and Corrected QT Intervals, Tpeak-End/QT, Tpeak-End/Corrected QT Ratios and Heart Rate Variability According to Decades in the Healthy Male Subjects Aged between 30 and 79 Years. Journal of Arrhythmia, 36, 508-517. [Google Scholar] [CrossRef] [PubMed]
[38] Duran, Ü.D., Duran, M., Tekin, E., et al. (2022) Comparison of the Effectiveness of Anti-Gravity Treadmill Exercises and Underwater Walking Exercises on Cardiorespiratory Fitness, Functional Capacity and Balance in Stroke Patients. Acta Neurologica Belgica, 123, 423-432. [Google Scholar] [CrossRef] [PubMed]
[39] Liu, Y., Gao, H., Wang, G., et al. (2019) A Comparison of the Effect of Sevoflurane and Propofol on Ventricular Repolarisation af-ter Preoperative Cefuroxime Infusion. BioMed Research International, 2019, Article ID: 8978906. [Google Scholar] [CrossRef] [PubMed]
[40] Abrich, V.A., Ramakrishna, H., Mehta, A., Mookadam, F. and Srivathsan, K. (2017) The Possible Role of Propofol in Drug-Induced Torsades de Pointes: A Real-World Single-Center Analysis. Interna-tional Journal of Cardiology, 232, 243-246. [Google Scholar] [CrossRef] [PubMed]
[41] Yayla, Ç., Özcan, F., Aras, D., et al. (2017) Tp-e Interval and Tp-e/QT Ratio before and after Catheter Ablation in Patients with Premature Ventricular Complexes. Biomarkers in Medicine, 11, 339-346. [Google Scholar] [CrossRef] [PubMed]
[42] Tang, X., Shi, L., Cui, X., et al. (2017) Renal Denervation Decreases Sus-ceptibility of the Heart to Ventricular Fibrillation in a Canine Model of Chronic Kidney Disease. Experimental Physiology, 102, 1414-1423. [Google Scholar] [CrossRef
[43] Suner, A. and Cetin, M. (2016) The Effect of Trimetazidine on Ventricular Re-polarization Indexes and Left Ventricular Diastolic Function in Patients with Coronary Slow Flow. Coronary Artery Disease, 27, 398-404. [Google Scholar] [CrossRef