早发冠心病合并2型糖尿病的研究进展
Progress in the Study of Premature Coronary Heart Disease Combined with Type 2 Diabetes Mellitus
摘要: 早发冠心病以起病较急、无先兆、预后较差为特点。随着冠心病发病年轻化,早发冠心病患者人群也在增加,糖尿病(diabetes mellitus, DM)容易加速动脉硬化与损伤进程,促进冠状动脉病变,导致冠心病(coronary heart disease, CHD),与单纯冠心病患者相比,合并糖尿病者冠状动脉病变更加弥漫而严重。本文通过早发冠心病合并2型糖尿病的诊断要点及相关的循证研究,从流行病学、危险因素、死亡率、发病机制等不同角度进行综述,并结合临床。以期为早发冠心病合并2型糖尿病的管理与防治提供思路。
Abstract: Premature coronary heart disease is characterized by a more rapid onset, no aura, and a poorer prognosis. As the incidence of coronary heart disease becomes younger, the number of patients with premature coronary heart disease is also increasing. Diabetes mellitus (DM) can easily accelerate the process of atherosclerosis and damage, and promote coronary artery disease, leading to coro-nary heart disease (CHD), and compared with patients with pure coronary heart disease, coronary artery disease in patients with diabetes mellitus is more diffuse and severe. In this paper, we re-view the diagnostic points of premature coronary heart disease combined with type 2 diabetes mellitus and related evidence-based studies from different perspectives, such as epidemiology, risk factors, mortality, pathogenesis, etc., and combine them with clinical practice. In order to provide ideas for the management and prevention of type 2 diabetes mellitus combined with premature coronary heart disease.
文章引用:任婕. 早发冠心病合并2型糖尿病的研究进展[J]. 临床医学进展, 2023, 13(9): 14043-14048. https://doi.org/10.12677/ACM.2023.1391964

参考文献

[1] 刘俊杰, 夏勇, 徐通达. 急性冠脉综合征合并2型糖尿病患者血栓弹力图变化的研究[J]. 中国急救复苏与灾害医学杂志, 2021, 16(9): 1015-1019.
[2] Kibel, A., Selthofer-Relatic, K., Drenjancevic, I., Bacun, T., Bosnjak, I., Kibel, D. and Gros, M. (2017) Coronary Microvascular Dysfunction in Diabetes Mellitus. Journal of International Medical Re-search, 45, 1901-1929. [Google Scholar] [CrossRef] [PubMed]
[3] 张杜丹, 唐迅, 靳丹瑶, 等. 中国成年人糖尿病患病率Meta分析[J]. 中华流行病学杂志, 2018, 39(6): 852-857.
[4] Targher, G. and Byrne, C.D. (2020) Treatment Algorithm in Patients with Type 2 Diabetes and Atherosclerotic Cardiovascular Disease or High/Very High Cardiovascular Risk. Eu-ropean Heart Journal, 41, 331. [Google Scholar] [CrossRef] [PubMed]
[5] Schernthaner, G., Shehadeh, N., Ametov, A.S., et al. (2020) World-wide Inertia to the Use of Cardiorenal Protective Glucose-Lowering Drugs (SGLT2i and GLP-1 RA) in High-Risk Pa-tients with Type 2 Diabetes. Cardiovascular Diabetology, 19, Article No. 185. [Google Scholar] [CrossRef] [PubMed]
[6] 胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220.
[7] Akosah, K.O., Schaper, A., Cogbill, C. and Schoenfeld, P. (2003) Preventing Myocardial Infarction in the Young Adult in the First Place: How Do the National Cholesterol Education Panel III Guidelines Perform? JACC: Journal of the American College of Cardiology, 41, 1475-1479. [Google Scholar] [CrossRef
[8] 胡盛涛, 高琳润, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220. [Google Scholar] [CrossRef
[9] 王媛, 张邢科, 马粉粉, 等. 中性粒细胞和淋巴细胞的比值及单核细胞和淋巴细胞的比值与早发冠心病的相关性分析[J]. 中国心血管病研究, 2021, 19(10): 910-915.
[10] Chen, G. and Levy, D. (2016) Contributions of the Framingham Heart Study to the Epidemiology of Coronary Heart Disease. JAMA Cardiology, 1, 825-830. [Google Scholar] [CrossRef] [PubMed]
[11] 中国心血管健康与疾病报告2021概要[J]. 中国循环杂志, 2022, 37(6): 553-578.
[12] 王海明, 邵钧捷, 周晶晶, 等. 早发冠心病患者的临床特征及发病危险因素分析[J]. 中国心血管病研究, 2022, 20(2): 154-160.
[13] Yusuf, S., Joseph, P., Rangarajan, S., et al. (2020) Modifiable Risk Factors, Cardiovascular Disease, and Mortality in 155722 Indi-viduals from 21 High-Income, Middle-Income, and Low-Income Countries (PURE): A Prospective Cohort Study. The Lancet, 395, 795-808. [Google Scholar] [CrossRef
[14] Maroszynsak, D.E. and Wozakowska, B. (2016) Clinical and Angiographic Characteristics of Coronary Artery Disease in Young Adults: A Single Centre Study. Kardiologia Polska, 74, 314-321. [Google Scholar] [CrossRef
[15] Lyengar, S.S., Gupta, R., Ravi, S., et al. (2017) Premature Coronary Artery Disease in India: Coronary Artery Disease in the Young (CADY) Registry. Indian Heart Journal, 69, 211-216. [Google Scholar] [CrossRef] [PubMed]
[16] Lu, Y., Hajifatallan, K., Ezzati, M., et al. (2014) Metabolic Mediators of the Effects of Body-Mass Index, Overweight, and Obesity on Coronary Heart Disease and Stroke: A Pooled Analysis of 97 Prospective Cohorts with 1.8 Million Participants. The Lancet, 383, 970-983. [Google Scholar] [CrossRef
[17] Wolsk, A.A., Reimuind, M., Sviridov, D.O., et al. (2021) Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases. Cells, 10, 597. [Google Scholar] [CrossRef] [PubMed]
[18] Huang, Y., Hu, Y., Mai, W., et al. (2011) Plasma Oxidized Low-Density Lipoprotein Is an Independent Risk Factor in Young Patients with Coronary Artery Disease. Disease Markers, 31, 295-301. [Google Scholar] [CrossRef] [PubMed]
[19] 苏广胜, 付茜, 庞文跃. 载脂蛋白B/载脂蛋白A1比值与青年冠心病患者冠状动脉病变严重程度的研究[J]. 临床心血管病杂志, 2021, 37(7): 663-667. [Google Scholar] [CrossRef
[20] 郁花, 邬登银. 体医结合模式运动干预对糖尿病患者控制效果评估[J]. 糖尿病天地, 2019, 16(8): 108-109.
[21] 李敏, 贾银虎. 2型糖尿病合并冠心病病人的临床特征及危险因素分析[J]. 中西医结合心脑血管病杂志, 2021, 19(23): 4135-4138.
[22] 张洪敏, 曹世杰, 邱峰, 等. 葛根和葛根素治疗糖尿病及并发症的研究进展[J]. 天津中医药大学学报, 2019, 38(6): 607-615.
[23] 刘琼, 李兵, 雷蕾, 等. 基于数据挖掘分析已上市中成药治疗糖尿病及其微血管并发症的用药规律[J]. 中国中医药信息杂志, 2021, 28(5): 25-31. [Google Scholar] [CrossRef
[24] 魏碧玥, 梁梅花. 糖尿病引起动脉粥样硬化作用机制研究的进展[J]. 心血管康复医学杂志, 2021, 30(1): 85-87.
[25] Aastha, C., Rajeev, C. and Shalini, J. (2016) Microvasular and Macrovascular Complications in Diabetes Mellitus: Distinct or Continuum. Indian Journal of Endocrinology and Metabolism, 20, 546-551. [Google Scholar] [CrossRef] [PubMed]
[26] Shenouda, R., Wester, P., et al. (2021) Carotid Atherosclerosis in Predicting Coronary Artery Disease: A Systematic Review and Meta-Analysis. Arteriosclerosis, Thrombosis & Vascular Biology, 41, 224-237. [Google Scholar] [CrossRef
[27] 王军媛, 张军, 刘颖, 等. 针药结合治疗2型糖尿病合并冠心病心绞痛: 随机对照研究[J]. 中国针灸, 2021, 41(4): 371-375. [Google Scholar] [CrossRef] [PubMed]
[28] 林怡莹, 杨瑞仪, 施巍, 等, 益气通络舒心汤辅助治疗2型糖尿病合并冠心病气虚血瘀证的临床疗效[J/OL]. 中国实验方剂学杂志: 1-8. 2021-04-24.[CrossRef
[29] Liu, W., Wang, T., Sun, P., et al. (2019) Expres-sion of Hcy and Blood Lipid Levels in Serum of CHD Patients and Analysis of Risk Factors for CHD. Experimental and Therapeutic Medicine, 17, 1756-1760. [Google Scholar] [CrossRef] [PubMed]
[30] Benjamin, E.J., Muntner, P., Alonso, A., et al. (2019) Heart Disease and Stroke Statistics-2019 Update: A Report from the American Heart Association. Circulation, 139, e56-e528. [Google Scholar] [CrossRef
[31] 卓瑜玉. 冠心病伴糖尿病患者血脂水平和冠脉病变特点分析[J]. 心血管病防治知识, 2020, 10(23): 20-22.
[32] 杨秀秀, 苏工. 2型糖尿病患者血糖变异性与冠状动脉病变程度之问的关系[J]. 心肺血管病杂志, 2017, 36(6): 440-443.
[33] Aikhani, M., Maclellan, C., Raptis, M., et al. (2006) Advanced Glycation End Products Induce Apoptosis in Fibroblasts through Activation of ROS, MAP Kinases and FOX O1 Transcription Factor. American Journal of Physiology-Cell Physiology, 291, 1293-1302.
[34] 马彩云, 任凤学, 许振业, 等. 冠心病合并糖尿病患者血清炎症因子水平变化及其临床意义[J]. 心肺血管病杂志, 2019, 38(4): 330-333+347.
[35] 阮政文, 江立生, 陈莲. 前列地尔对老年2型糖尿病合并冠心病患者心脏微循环和血清炎性因子水平的影响[J]. 中国老年学杂志, 2020, 40(21): 4531-4533.
[36] 汤海焦, 张松. 2型糖尿病大血管病变与血清生化物的研究进展[J]. 疑难病杂志, 2021, 20(4): 428-432.
[37] 何军华, 吴慧璐, 李慧. 2型糖尿病患者血糖波动对血管并发症的影响[J]. 中西医结合心脑血管杂志, 2014, 10(6): 759-761.
[38] 傅明洁, 秦政, 胡成平, 等. 冠心病合并2型糖尿病患者血小板分布宽度与支架内再狭窄的相关性研究[J]. 心肺血管病杂志, 2018, 37(7): 608-613.
[39] 金勇, 王燕, 李艳. 老年2型糖尿病伴冠心病患者HDL-C与SAA、VCAM-1、ICAM-1、THP-1的相关性研究[J]. 贵州医药, 2020, 44(2): 178-181.
[40] 张明帅, 于曼, 石现, 张臻, 林珊珊. 青年2型糖尿病合并冠心病病人临床特征及冠状动脉造影特点分析[J]. 中西医结合心脑血管病杂志, 2019, 17(20): 3165-3168.
[41] 刘旭杰, 张兴华. 青年冠心病研究进展[J]. 心血管病学进展, 2006, 27(6): 756-759.
[42] Newman, J.D., Rockman, C.B., Kosiborod, M., Guo, Y., Zhong, H., Weintraub, H.S., et al. (2017) Diabetes Mellitus Is a Coronary Heart Disease Risk Equivalent for Peripheral Vascular Disease. American Heart Journal, 184, 114-120. [Google Scholar] [CrossRef] [PubMed]
[43] van Zuydam, N.R., McCarthy, M.I. and Palmer, C.N.A. (2020) Ge-netic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. Circulation: Genomic and Precision Medi-cine, 13, e002769.
[44] Zeitouni, M., Clare, R.M., Chiswell, K., Abdulrahim, J., Shah, N., Pagidipati, N.P., et al. (2020) Risk Factor Burden and Long-Term Prognosis of Patients with Premature Coronary Artery Disease. Journal of the American Heart Association, 9, e017712. [Google Scholar] [CrossRef
[45] Kianoush, S., Rifai, M.A., Jain, V., Samad, Z., Rana, J., Dodani, S., et al. (2022) Prevalence and Predictors of Premature Coronary Heart Disease among Asians in the United States: A National Health Interview Survey Study. Current Problems in Cardiology, 48, Article ID: 101152. [Google Scholar] [CrossRef] [PubMed]
[46] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版) [J]. 中国糖尿病杂志, 2014, 30(8): 893-942.