骨钙素与葡萄糖代谢、能量代谢的研究进展
Advances in the Study of Osteocalcin, Glucose Metabolism and Energy Metabolism
DOI: 10.12677/BP.2023.133020, PDF,   
作者: 冯 吉：西安医学院研究生院，陕西 西安；郭 伟*：陕西省人民医院，全科医学科，陕西 西安
关键词: 骨钙素；葡萄糖代谢；能量代谢； Osteocalcin； Glucose Metabolism； Energy Metabolism
摘要: 骨钙素(OCN)是一种源自成骨细胞的非胶原蛋白，具有多种激素特征。动物和实验模型表明，骨钙素被释放到血液中，能够对胰腺细胞和脂肪组织产生生物学效应。近些年来，研究者们开始把骨骼作为一个内分泌器官重视起来，发现未完全羧化的骨钙素(ucOC)具有一定的活性，能够在葡萄糖代谢及能量代谢中发挥不可或缺的作用，这使得骨钙素可能在代谢性疾病，如糖尿病、肥胖和代谢综合征中具有潜在的治疗意义。
Abstract: Osteocalcin (OCN) is a non-collagenous protein derived from oste-oblasts with a variety of hormonal characteristics. Animal and experimental models have shown that osteocalcin is released into the bloodstream and is capable of producing biological effects on pancreatic cells and adipose tissue. In recent years, researchers have begun to focus on the skeleton as an endocrine organ, and have found that undercarboxylated osteocalcin (ucOC) is active and able to play an integral role in glucose metabolism and energy metabolism, which makes it potentially therapeutic in metabolic disorders such as diabetes mellitus, obesity, and metabolic syndrome.
文章引用：冯吉, 郭伟. 骨钙素与葡萄糖代谢、能量代谢的研究进展[J]. 生物过程, 2023, 13(3): 142-146. https://doi.org/10.12677/BP.2023.133020

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