眼球参数对iCare IC100眼压计和Goldmann压平式眼压计测量结果的影响

Effect of Eye Parameters on iCare IC100 Tonometer and Goldmann Applanation Tonometer Measurements

摘要: 目的：探讨中央角膜厚度、角膜曲率、角膜散光、白到白、前房深度、晶体厚度和眼轴长度对iCare IC100眼压计与Goldmann压平式眼压计(Goldmann applanation tonometry, GAT)测量结果的影响。方法：前瞻性研究。选取47例(73眼)门诊患者作为研究对象。采用IOL Master700测量患者中央角膜厚度、角膜曲率、角膜散光、白到白、前房深度、晶体厚度和眼轴长度，使用iCare IC100眼压计和GAT对所有患者进行眼压测量。采用线性相关分析比较iCare IC100和GAT的测量结果以及iCare IC100和GAT与中央角膜厚度、角膜曲率、角膜散光、白到白、前房深度、晶体厚度和眼轴长度的相关性，并进一步采用多重线性回归法分析相关性好的眼球参数与两种眼压计测量结果的关系。结果：使用iCare IC100和GAT测量眼压的平均值分别为(19.01 ± 7.68) mmHg和(18.99 ± 7.58) mmHg (r = 0.942, P = 0.000)。中央角膜厚度与iCare IC100和GAT测量值均明显相关(r = 0.527, P = 0.000; r = 0.485, P = 0.000)。中央角膜厚度每增加1 μm，iCare IC100测量值增加0.094 mmHg，GAT测量值增加0.085 mmHg。中央角膜厚度对iCare IC100测量值的影响较其对于GAT测量值的影响大。角膜散光与iCare IC100和GAT的测量值均明显相关(r = 0.246, P = 0.036; r = 0.309, P = 0.008)。角膜散光每增加1 D，iCare IC100测量值增加2.045 mmHg，GAT测量值增加2.662 mmHg。角膜散光对iCare IC100测量值的影响较其对于GAT测量值的影响小。眼轴每增加1 mm，iCare IC100测量值增加0.593 mmHg，GAT测量值增加0.489 mmHg。眼轴对iCare ic100测量值的影响较其对于GAT测量值的影响大。角膜曲率、白到白、前房深度、晶体厚度和眼轴长度与iCare IC100和GAT的测量值均无显著相关性(P均 > 0.05)。结论：中央角膜厚度、角膜散光和眼轴长度对iCare IC100和GAT的测量值均有影响，中央角膜厚度和眼轴长度对iCare IC100测量值的影响较其对于GAT的影响大，角膜散光对iCare IC100测量值的影响较其对于GAT的影响小。

Abstract: Objective: To investigate the effects of central corneal thickness, corneal curvature, corneal astigmatism, white to white, anterior chamber depth, lens thickness and axial length on the measurement results of iCare IC100 tonometer and Goldmann applanation tonometer (GAT). Methods: Prospective study. Forty-seven outpatients (73 eyes) were selected as study subjects. Central corneal thickness, corneal curvature, corneal astigmatism, white to white, anterior chamber depth, lens thickness and axial length were measured using the IOL Master700, and intraocular pressure measurements were performed in all patients using the iCare IC100 tonometer and GAT. Linear correlation analysis was used to compare the measurement results of iCare IC100 and GAT and the correlation between iCare IC100 and GAT and central corneal thickness, corneal curvature, corneal astigmatism, white to white, anterior chamber depth, lens thickness and eye axis length, and the relationship between the correlated parameters and the two tonometer measurements was further analyzed by multiple linear regression. Results: The mean values of iCare IC100 and GAT were (19.01 ± 7.68) mmHg and (18.99 ± 7.58) mmHg (r = 0.942, P = 0.000), respectively. Central corneal thickness was significantly correlated with iCare IC100 and GAT measurements (r = 0.527, P = 0.000; r = 0.485, P = 0.000). For every 1 μm increase in central corneal thickness, the iCare IC100 measurement increased by 0.094 mmHg and the GAT measurement increased by 0.085 mmHg. The thickness of the central cornea has a greater influence on the iCare IC100 measurement than it does on the GAT measurement. Corneal astigmatism was significantly correlated with the measurements of iCare IC100 and GAT (r = 0.246, P = 0.036; r = 0.309, P = 0.008). For every 1 D increase in corneal astigmatism, the iCare IC100 measurement increased by 2.045 mmHg and the GAT measurement increased by 2.662 mmHg. Corneal astigmatism has less effect on iCare IC100 measurements than it does on GAT measurements. For every 1 mm increase in the eye axis, the iCare IC100 measurement increases by 0.593 mmHg and the GAT measurement increases by 0.489 mmHg. The eye axis has a greater influence on the iCare IC100 measurement than it does on the GAT measurement. Corneal curvature, white to white, anterior chamber depth, lens thickness, and axial length were not significantly correlated with iCare IC100 and GAT measurements (all P > 0.05). Conclusion: Central corneal thickness, corneal astigmatism and axial length had greater effects on iCare IC100 and GAT measurements, central corneal thickness and axial length had greater effects on iCare IC100 measurements than GAT, and corneal astigmatism had less influence on iCare IC100 measurements than GAT.