酷似急性冠脉综合征的嗜酸性粒细胞性心肌炎一例
A Case of Eosinophilic Myocarditis Resembling Acute Coronary Syndrome
DOI: 10.12677/ACM.2023.1392003, PDF,   
作者: 邹 航, 王文涛:西安医学院研究生工作部,陕西 西安;陕西省人民医院心血管内二科,陕西 西安;寿锡凌*:陕西省人民医院心血管内二科,陕西 西安
关键词: 嗜酸性粒细胞性心肌炎嗜酸性粒细胞增多症Eosinophilic Myocarditis Hypereosinophilic Syndrome
摘要: 特发性嗜酸性粒细胞增多症(idiopathic hypereosinophilic syndrome, IHES)是一种罕见的疾病,以持续性嗜酸性粒细胞增多为特征,表现为多个器官受累。这种疾病病因不明,且预后不良。嗜酸性粒细胞性心肌炎(eosinophilic myocarditis, EM)是IHES的主要并发症之一,患者的临床表现多种多样,轻者可无明显症状,重者可表现为急性暴发性心肌炎。心内膜心肌活检是EM诊断的金标准,心脏核磁共振(cardiac magnetic resonance, CMR)可作为辅助诊断。本文对陕西省人民医院收治的一例临床表现酷似急性冠脉综合征的EM患者进行报道。因本患者属罕见病例,其诊治过程可能不具有普适性,针对不同个体时应制定个性化治疗方案。此外,本文并未深入探讨EM的病因及发病机制,期待进一步的相关研究报道。
Abstract: Idiopathic eosinophilia syndrome (IHES) is a rare disease characterized by persistent eosinophilia and multiple organ involvement. The etiology of this disease is unknown and the prognosis is poor. Eosinophilic myocarditis (EM) is one of the main complications of IHES. The clinical manifestations of patients are diverse, ranging from mild to asymptomatic to severe acute fulminant myocarditis. Endomyocardial biopsy is the gold standard for EM diagnosis, and cardiac magnetic resonance (CMR) can be used as an auxiliary diagnosis. This article reports a case of EM patient with clinical manifes-tations resembling acute coronary syndrome admitted to Shaanxi Provincial People’s Hospital. As this patient is a rare case, the diagnosis and treatment process may not be universal, and personal-ized treatment plans should be developed for different individuals. In addition, this article did not delve into the etiology and pathogenesis of EM, and further relevant research reports are expected.
文章引用:邹航, 王文涛, 寿锡凌. 酷似急性冠脉综合征的嗜酸性粒细胞性心肌炎一例[J]. 临床医学进展, 2023, 13(9): 14325-14330. https://doi.org/10.12677/ACM.2023.1392003

参考文献

[1] Weller, P.F. and Bubley, G.J. (1994) The Idiopathic Hypereosinophilic Syndrome. Blood, 83, 2759-2779. [Google Scholar] [CrossRef
[2] Shomali, W. and Gotlib, J. (2022) World Health Organiza-tion-Defined Eosinophilic Disorders: 2022 Update on Diagnosis, Risk Stratification, and Management. American Journal of Hematology, 97, 129-148. [Google Scholar] [CrossRef] [PubMed]
[3] Mankad, R., Bonnichsen, C. and Mankad, S. (2016) Hypereosinophilic Syndrome: Cardiac Diagnosis and Management. Heart, 102, 100-106. [Google Scholar] [CrossRef] [PubMed]
[4] Long, H., Zhang, G., Wang, L. and Lu, Q. (2016) Eosinophilic Skin Diseases: A Comprehensive Review. Clinical Reviews in Allergy & Immunology, 50, 189-213. [Google Scholar] [CrossRef] [PubMed]
[5] Weingarten, J.S., O’Sheal, S.F. and Margolis, W.S. (1985) Eo-sinophilic Meningitis and the Hypereosinophilic Syndrome. Case Report and Review of the Literature. The American Journal of Medicine, 78, 674-676. [Google Scholar] [CrossRef] [PubMed]
[6] Allen, J. and Wert, M. (2018) Eosinophilic Pneumonias. The Journal of Allergy and Clinical Immunology: In Practice, 6, 1455-1461. [Google Scholar] [CrossRef] [PubMed]
[7] Hinkle, L., Gandhi, N., Neal, R. and Narcisse, V. (2023) Hypereo-sinophilic Syndrome Presenting with Gastrointestinal Manifestations. BMJ Case Reports, 16, e254388. [Google Scholar] [CrossRef] [PubMed]
[8] Maisch, B. and Pankuweit, S. (2012) Current Treatment Options in (Peri)Myocarditis and Inflammatory Cardiomyopathy. Herz, 37, 644-656. [Google Scholar] [CrossRef] [PubMed]
[9] Ginsberg, F. and Parrillo, J.E. (2005) Eosinophilic Myocarditis. Heart Failure Clinics, 1, 419-429. [Google Scholar] [CrossRef] [PubMed]
[10] Li, H., Dai, Z., Wang, B. and Huang, W. (2015) A Case Report of Eosinophilic Myocarditis and a Review of the Relevant Literature. BMC Cardiovascular Disorders, 15, Article No. 15. [Google Scholar] [CrossRef] [PubMed]
[11] Brambatti, M., Matassini, M.V., Adler, E.D., et al. (2017) Eosin-ophilic Myocarditis: Characteristics, Treatment, and Outcomes. Journal of the American College of Cardiology, 70, 2363-2375. [Google Scholar] [CrossRef] [PubMed]
[12] Hogan, S.P., Rosenberg, H.F., Moqbel, R., et al. (2008) Eosinophils: Biological Properties and Role in Health and Disease. Clinical & Experimental Allergy, 38, 709-750. [Google Scholar] [CrossRef] [PubMed]
[13] Sano, K., Kobayashi, M., Sakaguchi, N., et al. (2001) A Rat Model of Hypereosinophilic Syndrome. Pathology International, 51, 82-88. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, N.-K., Kim, C.-Y., Kim, J.H., et al. (2015) A Hy-pereosinophilic Syndrome with Cardiac Involvement from Thrombotic Stage to Fibrotic Stage. Journal of Cardiovascu-lar Ultrasound, 23, 100-102. [Google Scholar] [CrossRef] [PubMed]
[15] Kuchynka, P., Palecek, T., Masek, M., et al. (2016) Current Diag-nostic and Therapeutic Aspects of Eosinophilic Myocarditis. BioMed Research International, 2016, Article ID: 2829583. [Google Scholar] [CrossRef] [PubMed]
[16] Francis, R. and Lewis, C. (2018) Myocardial Biopsy: Techniques and Indications. Heart, 104, 950-958. [Google Scholar] [CrossRef] [PubMed]
[17] Curtis, C. and Ogbogu, P. (2016) Hypereosinophilic Syndrome. Clinical Reviews in Allergy & Immunology, 50, 240-251. [Google Scholar] [CrossRef] [PubMed]
[18] Tefferi, A. (2005) Modern Diagnosis and Treatment of Primary Eosinophilia. Acta Haematologica, 114, 52-60. [Google Scholar] [CrossRef] [PubMed]
[19] Sen, T., Ponde, C.K. and Udwadia, Z.F. (2008) Hypereosinophilic Syn-drome with Isolated Loeffler’s Endocarditis: Complete Resolution with Corticosteroids. Journal of Postgraduate Medi-cine, 54, 135-137. [Google Scholar] [CrossRef] [PubMed]
[20] Wilkins, H.J., Crane, M.M., Copeland, K. and Williams, W.V. (2005) Hypereosinophilic Syndrome: An Update. American Journal of Hematology, 80, 148-157. [Google Scholar] [CrossRef] [PubMed]