误诊为自身免疫性疾病的惠普尔病1例

A Case of Whipple’s Disease Misdiagnosed as an Autoimmune Disease

摘要: 惠普尔病是由惠普尔养障体感染引起的一种罕见的慢性全身性疾病。最常见的症状是体重减轻、腹泻和腹痛。患者也可发生其他器官受累，其中最常见的是关节受累，关节表现为类风湿因子阴性关节炎或脊柱关节炎，大多数患者在体重减轻、腹泻之前会出现较长时间的关节、肌肉受累症状，这些症状通常会被误诊为自身免疫性疾病。了解惠普尔病对于自身免疫性疾病的鉴别诊断很重要。本文介绍了一例误诊为自身免疫性疾病的惠普尔病病例，旨在提高临床对惠普尔养障体感染的认识，做到早诊断、早治疗。

Abstract: Whipple’s disease is a rare chronic systemic disease caused by infection with Tropheryma whipplei. The most common symptoms are weight loss, diarrhoea and abdominal pain. Patients may also de-velop other organ involvement, most commonly joint involvement in the form of rheumatoid fac-tor-negative arthritis or spondyloarthritis, and in most patients, weight loss and diarrhoea are pre-ceded by a prolonged period of joint and muscle involvement, which is often misdiagnosed as an autoimmune disease. Understanding Whipple’s disease is important for the differential diagnosis of autoimmune diseases. This article presents a case of Whipple’s disease misdiagnosed as an auto-immune disease, with the aim of improving clinical understanding of Whipple’s barrier organism infection and achieving early diagnosis and treatment.