冠状动脉瘤样扩张研究进展
Research Progress of Coronary Artery Aneu-rysms
DOI: 10.12677/ACM.2023.1392028, PDF,   
作者: 再米然·努尔塔, 罗 梅*:新疆医科大学第五临床医学院老年医学科,新疆 乌鲁木齐;伊力亚斯·亚尔买买提:新疆医科大学附属肿瘤医院影像中心,新疆 乌鲁木齐
关键词: 冠状动脉瘤样扩张心血管不良事件临床特点治疗管理Coronary Artery Aneurysms Adverse Cardiovascular Events Clinical Characteristics Treatment Management
摘要: 冠状动脉瘤样扩张是冠状动脉的异常扩张,在临床上不常见,但也并不罕见的一种心血管疾病,其发生率为0.3%~5.3%。目前缺乏冠状动脉瘤样扩张患者的随机试验或大规模流行病学调查数据,因此针对这些患者的管理,使心脏病专家及临床医生面临相当大的挑战。很多情况下,冠状动脉瘤样扩张是行冠脉造影术患者中偶然发现的,并且发病机制仍有争议。治疗方法包括外科手术、经皮冠状动脉介入治疗和药物治疗。本文主要集中描述冠状动脉瘤样扩张的病因、发病机制、病理生理、诊断以及治疗等方面的临床特点,为进一步管理提供临床依据。
Abstract: Coronary artery aneurysms is an abnormal dilation of the coronary artery and is a cardiovascular disease that is not common but also not rare, with an incidence rate of 0.3%~5.3%. Currently, there is a lack of randomized trials or large-scale epidemiological surveys on patients with coronary ar-tery ectasia, so the management of these patients poses a significant challenge for cardiologists and clinicians. In many cases, coronary artery aneurysm is incidentally discovered during coronary an-giography, and the pathogenesis is still controversial. Treatment options include surgical operation, percutaneous coronary intervention, and medical therapy. This article mainly focuses on the clinical characteristics of coronary artery aneurysm in terms of etiology, pathogenesis, pathophysiology, diagnosis, and treatment, providing clinical evidence for further management.
文章引用:再米然·努尔塔, 罗梅, 伊力亚斯·亚尔买买提. 冠状动脉瘤样扩张研究进展[J]. 临床医学进展, 2023, 13(9): 14504-14511. https://doi.org/10.12677/ACM.2023.1392028

参考文献

[1] Sheng, Q., Zhao, H., Wu, S., et al. (2020) Underlying Factors Relating to Acute Myocardial Infarction for Coronary Ar-tery Ectasia Patients. Medicine (Baltimore), 99, e21983. [Google Scholar] [CrossRef
[2] Zhu, X., Zhou, Q., Tong, S., et al. (2021) Challenges and Strategies in the Management of Coronary Artery Aneurysms. Hel-lenic Journal of Cardiology, 62, 112-120. [Google Scholar] [CrossRef] [PubMed]
[3] Khedr, A., Neupane, B., Proskuriakova, E., et al. (2021) Pharmacologic Management of Coronary Artery Ectasia. Cureus, 13, e17832. [Google Scholar] [CrossRef] [PubMed]
[4] Eid, M.M., Mostafa, M.R., Alabdouh, A., et al. (2023) Long-Term Outcomes of Acute Myocardial Infarction in Pre-Existing Coronary Artery Ectasia: A Systematic Review and Me-ta-Analysis. Current Problems in Cardiology, 48, Article ID: 101626. [Google Scholar] [CrossRef] [PubMed]
[5] Núñez-Gil, I.J., Cerrato, E., Bollati, M. and CAAR Investi-gators (2020) Coronary Artery Aneurysms, Insights from the International Coronary Artery Aneurysm Registry (CAAR). International Journal of Cardiology, 299, 49-55.
[6] Kawsara, A., Núñez Gil, I.J., Alqahtani, F., et al. (2018) Management of Coronary Artery Aneurysms. JACC: Cardiovascular Interventions, 11, 1211-1223. [Google Scholar] [CrossRef] [PubMed]
[7] Ahmad, M. and Mungee, S. (2022) Coronary Ectasia. StatPearls, Treasure Island.
[8] Pham, V., Hemptinne, Q., Grinda, J., et al. (2020) Giant Coronary Aneurysms, from Diagnosis to Treatment: A Literature Review. Archives of Cardiovascular Diseases, 113, 59-69. [Google Scholar] [CrossRef] [PubMed]
[9] McCrindle, B.W., Rowley, A.H., Newburger, J.W., et al. (2017) Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Profession-als from the American Heart Association. Circulation, 135, e927-e999.
[10] Abou Sherif, S., Ozden Tok, O., Taşköylü, Ö., et al. (2017) Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treat-ment. Frontiers in Cardiovascular Medicine, 4, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[11] Jeudy, J., White, C.S., Kligerman, S.J., et al. (2018) Spectrum of Coronary Artery Aneurysms: From the Radiologic Pathology Archives. Radiographics, 38, 11-36. [Google Scholar] [CrossRef] [PubMed]
[12] Vrachatis, D.A., Papathanasiou, K.A., Kazantzis, D., et al. (2022) In-flammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis. Diagnostics (Basel), 12, Article No. 1026. [Google Scholar] [CrossRef] [PubMed]
[13] Dereli, S., Çerik, İ.B., Kaya, A., et al. (2020) Assessment of the Relationship between C-Reactive Protein-to-Albumin Ratio and the Presence and Severity of Isolated Coronary Artery Ectasia. Angiology, 71, 840-846. [Google Scholar] [CrossRef] [PubMed]
[14] Franco-Peláez, J.A., Martín-Reyes, R., Pello-Lázaro, A.M., et al. (2020) Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome. Journal of Clinical Medicine, 9, 3037. [Google Scholar] [CrossRef] [PubMed]
[15] 李静, 韩雅君. 冠状动脉瘤样扩张研究进展[J]. 内蒙古医学杂志, 2020, 52(3): 287-289.
[16] Denby, K.J., Clark, D.E., Markham, L.W., et al. (2017) Management of Kawasaki Disease in Adults. Heart, 103, 1760-1769. [Google Scholar] [CrossRef] [PubMed]
[17] Rife, E., Gedalia, A., et al. (2020) Kawasaki Disease: An Update. Current Rheumatology Reports, 22, Article No. 75. [Google Scholar] [CrossRef] [PubMed]
[18] Kuo, H.C., Li, S.C., Huang, L.H. and Huang, Y.H. (2017) Epi-genetic Hypomethylation and Upregulation of Matrix Metalloproteinase 9 in Kawasaki Disease. Oncotarget, 8, 60875-60891. [Google Scholar] [CrossRef] [PubMed]
[19] Fu, F.F., Chen, X. and Xing, L. (2023) Association between Ratio of White Blood Cells to Mean Platelet Volume and Coronary Artery Ectasia. Angiology. [Google Scholar] [CrossRef] [PubMed]
[20] Friedman, K.G., Gauvreau, K., Hamaoka-Okamoto, A., et al. (2016) Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population. Journal of the American Heart Association, 5, e003289. [Google Scholar] [CrossRef
[21] Demirelli, S., Degirmenci, H., Inci, S., et al. (2015) Cardiac Mani-festations in Behcet’s Disease. Intractable & Rare Diseases Research, 4, 70-75. [Google Scholar] [CrossRef] [PubMed]
[22] Serra, R., Butrico, L., Fugetto, F., et al. (2016) Updates in Patho-physiology, Diagnosis and Management of Takayasu Arteritis. Annals of Vascular Surgery, 35, 210-225. [Google Scholar] [CrossRef] [PubMed]
[23] Jennette, J.C., Falk, R.J., Bacon, P.A., et al. (2013) 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis & Rheumatology, 65, 1-11.
[24] Watts, R.A., Scott, D.G., et al. (2016) Vasculitis and Inflammatory Arthritis. Best Practice & Research: Clin-ical Rheumatology, 30, 916-931. [Google Scholar] [CrossRef] [PubMed]
[25] MacCarrick, G., Black, J.H., Bowdin, S., et al. (2014) Loeys-Dietz Syndrome: A Primer for Diagnosis and Management. Genetics in Medicine, 16, 576-587. [Google Scholar] [CrossRef] [PubMed]
[26] Kuzyk, J., Boiko, O., Stetsko, T., et al. (2018) Fibromuscular Dysplasia of the Coronary Arteries: A Case Report and Review of the Literature. Türk Patoloji Dergisi, 34, 269-273.
[27] Borgi, J.F., Natrajan, K.M., Sun, J.C., et al. (2014) Mycotic Aneurysm of the Right Coronary Artery Presenting as Infected Pericardial Effusion. Circulation, 130, e7-e8. [Google Scholar] [CrossRef
[28] Ali, Z.A., Karimi Galougahi, K., Mintz, G.S., et al. (2021) Intracoronary Optical Coherence Tomography: State of the Art and Future Directions. EuroIntervention, 17, e105-e123. [Google Scholar] [CrossRef
[29] Mir, T., Sattar, Y., Uddin, M., et al. (2021) Post-PCI Outcomes in STEMI Patients with Coronary Ectasia: Meta-Analysis. Expert Review of Cardiovascular Therapy, 19, 349-356. [Google Scholar] [CrossRef] [PubMed]
[30] Satran, A., Bart, B.A., Henry, C.R., et al. (2005) Increased Prevalence of Coronary Artery Aneurysms among Cocaine Users. Circulation, 111, 2424-2429. [Google Scholar] [CrossRef
[31] Fathelbab, H., Camacho Freire, S.J., León Jiménez, J., et al. (2017) Detection of Spontaneous Coronary Artery Spasm with Optical Coherence Tomography in a Patient with Acute Coronary Syndrome. Cardiovascular Revascularization Medicine, 18, 7-9. [Google Scholar] [CrossRef] [PubMed]
[32] Esposito, L., Di Maio, M., Silverio, A., et al. (2022) Treatment and Outcome of Patients with Coronary Artery Ectasia: Current Evidence and Novel Opportunities for an Old Dilemma. Frontiers in Cardiovascular Medicine, 8, Article ID: 805727. [Google Scholar] [CrossRef] [PubMed]
[33] Richards, G.H.C., Hong, K.L., Henein, M.Y., et al. (2022) Coro-nary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts. International Journal of Molecular Sciences, 23, Article No. 5195. [Google Scholar] [CrossRef] [PubMed]
[34] Bogana Shanmugam, V., Psaltis, P.J., Wong, D., et al. (2017) Out-comes after Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Caused by Ectatic In-farct Related Arteries. Heart, Lung and Circulation, 26, 1059-1068. [Google Scholar] [CrossRef] [PubMed]
[35] Baldi, C., Silverio, A., Esposito, L., et al. (2022) Clinical Outcome of Patients with ST-Elevation Myocardial Infarction and Angiographic Evidence of Coronary Artery Ectasia. Catheteri-zation and Cardiovascular Interventions, 99, 340-347. [Google Scholar] [CrossRef] [PubMed]
[36] Campanile, A., Soz-zi, F.B., Consonni, D., et al. (2014) Primary PCI for the Treatment of Ectatic Infarct-Related Coronary Artery. Minerva Cardioangiologica, 62, 327-333.
[37] Schram, H.C.F., Hemradj, V.V., Hermanides, R.S., et al. (2018) Coronary Artery Ectasia, an Independent Predictor of No-Reflow after Primary PCI for ST-Elevation Myocardial Infarction. International Journal of Cardiology, 265, 12-17. [Google Scholar] [CrossRef] [PubMed]
[38] Tehrani, S., Faircloth, M., Chua, T.P., et al. (2021) Percutaneous Coronary Intervention in Coronary Artery Aneurysms, Technical Aspects. Report of Case Series and Literature Review. Cardiovascular Revascularization Medicine, 28S, 243-248. [Google Scholar] [CrossRef] [PubMed]
[39] Doi, T., Kataoka, Y., Noguchi, T., et al. (2017) Coronary Artery Ectasia Predicts Future Cardiac Events in Patients with Acute Myocardial Infarction. Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 2350-2355. [Google Scholar] [CrossRef
[40] Fan, C.H., Hao, Y., Liu, Y.H., et al. (2020) An-ti-Inflammatory Effects of Rosuvastatin Treatment on Coronary Artery Ectasia Patients of Different Age Groups. BMC Cardiovascular Disorders, 20, Article No. 330. [Google Scholar] [CrossRef] [PubMed]