越鞠丸治疗室性期前收缩–痰瘀互阻型的临床疗效观察

Clinical Observation on the Effect of Yueju Pill in Treating Ventricular Premature Contraction Phlegm and Blood Stasis Blocking Type

摘要: 目的：通过观察分析越鞠丸治疗室性期前收缩–痰瘀互阻型患者的临床症状、室性早搏次数和中医证候积分的影响，评价越鞠丸治疗室性期前收缩–痰瘀互阻型的临床疗效。方法：选取就诊于青岛大学附属青岛市海慈医院心血管内科符合纳入标准的患者80例，采用随机数字表法分为观察组和对照组各40例。对照组采用常规的循证治疗，观察组在对照组的基础上加用越鞠丸治疗，连续使用4周。观察患者治疗前后临床症状、中医证候积分和24小时动态心电图(Holter)室性早搏次数、心室率(HR)、等变化情况，以及治疗期间的不良反应发生情况。采用统计学SPSS24.0进行数据分析和处理。结果：1) 两组患者中医证候积分，治疗组改善中医全身症状效果优于对照组(P < 0.05)；2) 两组患者的室性早搏发作次数均有所改善，且观察组改善程度明显优于对照组，差异明显(P < 0.05)。结论：采用越鞠丸治疗室性期前收缩—痰瘀互阻型，可以明显提高临床治疗效果，有效改善患者的中医临床症状，降低治疗期间的不良反应，具有明显的临床价值。

Abstract: Objective: To evaluate the clinical efficacy of Yueju Pill in treating patients with ventricular prema-ture contractions phlegm stasis obstruction type by observing and analyzing the clinical symptoms, the frequency of ventricular premature contractions, and the impact of traditional Chinese medi-cine syndrome scores. Method: 80 patients who met the inclusion criteria in the Cardiovascular De-partment of Haici Hospital affiliated with Qingdao University were selected and divided into an ob-servation group and a control group using a random number table method, with 40 patients in each group. The control group received routine evidence-based treatment, while the observation group received additional treatment with Yueju Pill for 4 consecutive weeks. Observe the clinical symp-toms, traditional Chinese medicine syndrome scores, 24-hour dynamic electrocardiogram (Holter), ventricular premature beats, ventricular rate (HR), and other changes of the patient before and af-ter treatment, as well as the occurrence of adverse reactions during the treatment period. Statisti-cal SPSS 24.0 was used for data analysis and processing. Result: 1) The TCM syndrome score of the two groups, the treatment group to improve the systemic symptoms of traditional Chinese medicine effect was better than the control group (P < 0.05). 2) The two groups of patients with ventricular premature beat episodes were improved, and the observation group was significantly better than the control group, the difference was significant (P < 0.05). Conclusion: The use of Yueju Pill in the treatment of ventricular premature contractions phlegm stasis obstruction type can significantly improve clinical treatment effectiveness, effectively improve patients’ TCM clinical symptoms, re-duce adverse reactions during treatment, and have high clinical value.