间充质干细胞治疗炎症性疾病的研究进展
Research Progress in the Treatment of Inflammatory Diseases with Mesenchymal Stem Cells
DOI: 10.12677/ACM.2023.1392052, PDF,    科研立项经费支持
作者: 陈 于：重庆医科大学第二临床学院，重庆；曾 勇：重庆医科大学附属第二医院急诊科，重庆
关键词: 间充质干细胞；炎症性疾病；治疗；制备；Mesenchymal Stem Cells； Inflammatory Diseases； Treatment； Preparation
摘要: 炎症性疾病是存在于人类生命活动中的普遍性疾病，严重威胁着人们的生命健康。目前，炎症性疾病的治疗方法主要是药物对症治疗。由于缺乏有效的治疗方式，患者面临预后不良的问题。间充质干细胞(mesenchymal stem cells, MSCs)具有抗炎和免疫调节、分化成损伤细胞、归巢到炎症部位等功能，所有这些都是炎症性疾病治疗的关键点。尽管目前国内外有大量制备MSCs的方法，但由于缺乏统一标准，导致制备的MSCs数量、活性、纯度、表型和分化潜能有较大差异，从而进一步导致临床试验效果各异和基础研究结论不一。本文就MSCs的制备、MSCs在炎症性疾病中的作用机制、MSCs在炎症性疾病中的应用进行综述。
Abstract: Inflammatory diseases are universal diseases existing in human life activities, which seriously threaten people’s life and health. At present, the treatment of inflammatory diseases is mainly drug symptomatic treatment. Due to the lack of effective treatment, patients face a poor prognosis. mes-enchymal stem cells (MSCs) have functions such as anti-inflammatory and immune regulation, dif-ferentiation into damaged cells, and homing to inflammatory sites, all of which are key points in the treatment of inflammatory diseases. Although there are a large number of methods for preparing MSCs at home and abroad, due to the lack of unified standards, the number, activity, purity, pheno-type and differentiation potential of prepared MSCs are quite different, which further leads to dif-ferent clinical trial effects and different basic research conclusions. This article reviews the prepa-ration of MSCs, the mechanism of action of MSCs in inflammatory diseases, and the application of MSCs in inflammatory diseases.
文章引用：陈于, 曾勇. 间充质干细胞治疗炎症性疾病的研究进展[J]. 临床医学进展, 2023, 13(9): 14678-14686. https://doi.org/10.12677/ACM.2023.1392052

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