关节镜手术联合不同时期制取的富血小板血浆治疗中早期膝骨关节炎患者的临床疗效

Arthroscopic Surgery Combined with Platelet-Rich Plasma Produced at Different Times Clinical Efficacy in the Treatment of Patients with Early-Stage Knee Osteoarthritis

摘要: 目的：探讨膝关节镜手术联合富血小板血浆治疗膝骨关节炎的临床疗效，并对制取时期不同所产生的影响进行探究。方法：回顾分析自2021年8月至2022年4月就诊于我院并行膝关节镜手术联合富血小板血浆治疗的膝骨关节炎患者60例，并根据制取时期分为实验组(术前制取PRP，共34例)和对照组(术后制取PRP，共26例)，对比患者治疗后在视觉模拟量表(Vas)评分、Womac评分以及Lysholm评分的变化评估患者症状改变。结果：治疗后患者的Vas评分、Womac评分以及Lysholm评分均较治疗前有明显改善，且评分改变有统计学意义(P < 0.05)；两组治疗前与治疗后各项评分的变化程度对比无明显差异(P > 0.05)；术后两组患者均出现不同程度的血液炎性因子升高，在实验组中患者未出现任何特殊不良反应，而在对照组中我们发现有2例患者出现膝关节肿痛的现象，但该现象与术后患者自身炎性因子改变无明显相关性(P > 0.05)。结论：关节镜手术联合富血小板血浆能够缓解患者膝关节疼痛，改善膝关节功能，其中实验组末次随访评分展现出了较好的结果，但差异无统计学意义。

Abstract: Objective: To investigate the therapeutic effect of knee arthroscopic surgery combined with plate-let-rich plasma in the treatment of knee osteoarthritis, and to explore the effects of different pro-duction periods. Methods: A retrospective analysis was conducted on 60 patients with knee osteo-arthritis who underwent knee arthroscopic surgery combined with platelet rich plasma treatment at our hospital from August 2021 to April 2022. They were divided into an experimental group (34 patients were treated with preoperative PRP) and a control group (26 patients were treated with postoperative PRP) based on the preparation period. The changes in visual analogue scale (Vas) score, Womac score, and Lysholm score were compared to evaluate the symptoms of the patients after treatment. Results: After treatment, the Vas score, Womac score, and Lysholm score of the pa-tients showed significant improvement compared to before treatment, and the changes in scores were statistically significant (P < 0.05); there was no significant difference in the degree of changes in various scores between the two groups before and after treatment (P > 0.05); After surgery, both groups of patients showed varying degrees of elevated blood inflammatory factors. In the experi-mental group, patients did not experience any special adverse reactions, while in the control group, we found 2 patients with knee joint swelling and pain. However, this phenomenon was not signifi-cantly correlated with postoperative changes in patients’ own inflammatory factors (P > 0.05). Con-clusion: Arthroscopic surgery combined with platelet rich plasma can alleviate knee pain and im-prove knee function in patients. The experimental group showed good results in the last follow-up score, but the difference was not statistically significant.