颈动脉斑块内新生血管与2型糖尿病合并冠心病的关系研究
A Study of the Relationship between Neovascularization in Carotid Plaque and Type 2 Diabetes Mellitus with Coronary Heart Disease
DOI: 10.12677/ACM.2023.1392062, PDF,   
作者: 程明慧：华北理工大学附属医院放射科，河北 唐山 ；任 杰, 靳玉倩, 魏剑芬*, 焦丽静, 阚芳芳, 盛佳曦：华北理工大学附属医院内分泌科，河北 唐山
关键词: 2型糖尿病；颈动脉斑块新生血管；冠心病；Type 2 Diabetes Mellitus； Carotid Plaque Neovascularization； Coronary Heart Disease
摘要: 目的：通过分析2型糖尿病伴颈动脉斑块患者血糖、血脂、胰岛素等指标与斑块内新生血管形成情况及合并冠心病情况，了解其与T2DM颈动脉斑块内新生血管的关系，为T2DM合并冠心病预防及诊治提供新的靶点。方法：选取于2021年5月至2022年4月华北理工大学附属医院内分泌科住院的T2DM患者110例，依据颈动脉超声造影结果，将患者分为颈动脉斑块内有新生血管组(病例组)患者56例，颈动脉斑块内无新生血管组(对照组)患者54例。测定血脂、血糖、胰岛功能、糖化血红蛋白、血压，计算体重指数及胰岛素抵抗指数，分析合并冠心病比例及斑块内新生血管与冠心病关系。结果：1) 颈动脉斑块内有新生血管组发生冠心病的风险升高1.78倍；2) 两组间糖尿病病程、BMI、SBP、DBP、TC、TG、LDL-C、HbA1c、FBP、IR差异具有统计学意义(P < 0.05)。结论：颈动脉斑块内新生血管形成增加了糖尿病患者心血管疾病的风险，可作为预测冠心病的因子。
Abstract: Objectives: By analyzing the indexes of blood glucose, blood lipids and insulin, neovascularization within plaques and combined coronary heart disease in patients with type 2 diabetes mellitus (T2DM) with carotid plaques, to understand the relationship with neovascularization within carotid plaques of T2DM, to provide new targets for the prevention and diagnosis of T2DM combined with coronary heart disease. Methods: One hundred and ten patients with T2DM who were hospitalized in the endocrine department of Affiliated Hospital of North China University of Science and Tech-nology from May 2021 to April 2022 were selected. Based on the results of carotid ultrasonography, the patients were divided into 56 patients in the group with neovascularization in the carotid plaque (case group) and 54 patients in the group without neovascularization in the carotid plaque (control group). Lipids, blood glucose, pancreatic islet function, glycosylated hemoglobin, and blood pressure were measured, and body mass index and insulin resistance index were calculated. To an-alyze the proportion of combined coronary artery disease and the relationship between intraplaque neovascularization and coronary artery disease. Result: 1) The risk of coronary heart disease in the group with neovascularization within the carotid plaque was elevated by 1.78 times; 2) The differ-ences in diabetes duration, BMI, SBP, DBP, TC, TG, LDL-C, HbA1c, FBP, IR between the two groups were statistically significant (P < 0.05). Conclusions: Neovascularization within carotid plaques in-creases the risk of cardiovascular disease in diabetic patients and may serve as a predictor of coro-nary heart disease.
文章引用：程明慧, 任杰, 靳玉倩, 魏剑芬, 焦丽静, 阚芳芳, 盛佳曦. 颈动脉斑块内新生血管与2型糖尿病合并冠心病的关系研究[J]. 临床医学进展, 2023, 13(9): 14744-14749. https://doi.org/10.12677/ACM.2023.1392062

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