NLRP3、氧化应激在动脉粥样硬化中作用
The Role of NLRP3 and Oxidative Stress in Atherosclerosis
摘要: 动脉粥样硬化(AS)是冠心病(CHD)、脑梗死等心脑血管事件发生的重要病理生理基础，是一种慢性适应不良，由内皮功能障碍和内皮下脂蛋白聚集的相互作用引起，而且是不可逆转的炎症性疾病。近年来研究显示，作为炎性小体核心的NOD样受体家族含pyrin结构域蛋白3 (NLRP3)，其活化及活性调节在AS进程中具有重要的生理病理学意义。动脉粥样硬化的炎症性质已被证实，但关于激发动脉壁炎症的因子仍在很大程度上未知。在动脉粥样硬化形成过程中，有几种假说与动脉狭窄相关。氧化修饰假说与氧化和抗氧化失衡有关，是研究最多的假说。本文基于文献资料，探讨分析了NLRP3炎症小体和氧化应激对动脉粥样硬化发生发展的影响。
Abstract: Atherosclerosis (AS) is an important pathophysiological basis for cardiovascular and cerebrovascu-lar events such as coronary heart disease (CHD) and cerebral infarction, and is a chronic maladapta-tion, caused by the interaction of endothelial dysfunction and subendothelial lipoprotein aggrega-tion, and is an irreversible inflammatory disease. In recent years, studies have shown that the acti-vation and activity regulation of pyrin-containing domain protein 3 (NLRP3), a family of NOD-like receptors as the core of inflammosomes, have important physiopathological significance in the pro-cess of AS. The inflammatory properties of atherosclerosis have been confirmed, but the factors that provoke inflammation of arterial walls remain largely unknown. During atherosclerotic formation, several hypotheses are associated with arterial stenosis. The oxidative modification hypothesis is related to oxidation and antioxidant imbalance and is the most studied hypothesis. Based on liter-ature, this paper analyzes the effects of NLRP3 inflammasome and oxidative stress on the occur-rence and development of atherosclerosis.
文章引用：任文莹. NLRP3、氧化应激在动脉粥样硬化中作用[J]. 临床医学进展, 2023, 13(9): 14758-14763. https://doi.org/10.12677/ACM.2023.1392064

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